Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | GNF2_CASP1 |
| Enrichment Score (ES) | -0.42616808 |
| Normalized Enrichment Score (NES) | -1.6239555 |
| Nominal p-value | 0.001968504 |
| FDR q-value | 0.10972031 |
| FWER p-Value | 0.534 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CD302 | NA | CD302 Entrez, Source | CD302 molecule | 201 | 3.271 | 0.0213 | No |
| 2 | AP1S2 | NA | AP1S2 Entrez, Source | adaptor-related protein complex 1, sigma 2 subunit | 349 | 2.997 | 0.0422 | No |
| 3 | RGS2 | NA | RGS2 Entrez, Source | regulator of G-protein signalling 2, 24kDa | 561 | 2.704 | 0.0582 | No |
| 4 | CPVL | NA | CPVL Entrez, Source | carboxypeptidase, vitellogenic-like | 583 | 2.690 | 0.0810 | No |
| 5 | COTL1 | NA | COTL1 Entrez, Source | coactosin-like 1 (Dictyostelium) | 882 | 2.402 | 0.0911 | No |
| 6 | PSAP | NA | PSAP Entrez, Source | prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) | 903 | 2.388 | 0.1113 | No |
| 7 | PPT1 | NA | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 1566 | 1.942 | 0.1041 | No |
| 8 | TMEM127 | NA | TMEM127 Entrez, Source | transmembrane protein 127 | 2045 | 1.700 | 0.1014 | No |
| 9 | CCR1 | NA | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 2059 | 1.692 | 0.1158 | No |
| 10 | GABARAP | NA | GABARAP Entrez, Source | GABA(A) receptor-associated protein | 2063 | 1.692 | 0.1305 | No |
| 11 | C1orf38 | NA | C1ORF38 Entrez, Source | chromosome 1 open reading frame 38 | 3097 | 1.278 | 0.1038 | No |
| 12 | FBXL5 | NA | FBXL5 Entrez, Source | F-box and leucine-rich repeat protein 5 | 3322 | 1.208 | 0.1061 | No |
| 13 | NAAA | NA | 3783 | 1.057 | 0.0985 | No | ||
| 14 | SKAP2 | NA | SKAP2 Entrez, Source | src kinase associated phosphoprotein 2 | 3810 | 1.047 | 0.1067 | No |
| 15 | PLCB2 | NA | PLCB2 Entrez, Source | phospholipase C, beta 2 | 4037 | 0.977 | 0.1070 | No |
| 16 | GMFG | NA | GMFG Entrez, Source | glia maturation factor, gamma | 4153 | 0.945 | 0.1111 | No |
| 17 | ZDHHC7 | NA | ZDHHC7 Entrez, Source | zinc finger, DHHC-type containing 7 | 4308 | 0.905 | 0.1133 | No |
| 18 | CFP | NA | CFP Entrez, Source | complement factor properdin | 4773 | 0.795 | 0.1033 | No |
| 19 | MAFB | NA | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 5115 | 0.716 | 0.0970 | No |
| 20 | FKBP15 | NA | 5208 | 0.692 | 0.0997 | No | ||
| 21 | LILRA1 | NA | LILRA1 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 | 5339 | 0.652 | 0.1006 | No |
| 22 | MFSD1 | NA | MFSD1 Entrez, Source | major facilitator superfamily domain containing 1 | 5479 | 0.622 | 0.1010 | No |
| 23 | S100A4 | NA | S100A4 Entrez, Source | S100 calcium binding protein A4 | 6035 | 0.521 | 0.0852 | No |
| 24 | CSGALNACT2 | NA | 6159 | 0.503 | 0.0851 | No | ||
| 25 | CLEC4A | NA | CLEC4A Entrez, Source | C-type lectin domain family 4, member A | 6642 | 0.436 | 0.0712 | No |
| 26 | MYO1F | NA | MYO1F Entrez, Source | myosin IF | 6655 | 0.434 | 0.0746 | No |
| 27 | PILRA | NA | PILRA Entrez, Source | paired immunoglobin-like type 2 receptor alpha | 7127 | 0.384 | 0.0606 | No |
| 28 | TNFRSF1B | NA | TNFRSF1B Entrez, Source | tumor necrosis factor receptor superfamily, member 1B | 7512 | 0.343 | 0.0495 | No |
| 29 | DAZAP2 | NA | DAZAP2 Entrez, Source | DAZ associated protein 2 | 8574 | 0.258 | 0.0128 | No |
| 30 | LILRB3 | NA | LILRB3 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 8630 | 0.254 | 0.0130 | No |
| 31 | MS4A6A | NA | MS4A6A Entrez, Source | membrane-spanning 4-domains, subfamily A, member 6A | 9938 | 0.181 | -0.0334 | No |
| 32 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 10099 | 0.174 | -0.0378 | No |
| 33 | TLR8 | NA | TLR8 Entrez, Source | toll-like receptor 8 | 10189 | 0.171 | -0.0395 | No |
| 34 | HK3 | NA | HK3 Entrez, Source | hexokinase 3 (white cell) | 10507 | 0.155 | -0.0498 | No |
| 35 | TYROBP | NA | TYROBP Entrez, Source | TYRO protein tyrosine kinase binding protein | 10577 | 0.152 | -0.0510 | No |
| 36 | CMTM6 | NA | CMTM6 Entrez, Source | CKLF-like MARVEL transmembrane domain containing 6 | 10920 | 0.136 | -0.0624 | No |
| 37 | CECR1 | NA | CECR1 Entrez, Source | cat eye syndrome chromosome region, candidate 1 | 11840 | 0.096 | -0.0953 | No |
| 38 | PYCARD | NA | PYCARD Entrez, Source | PYD and CARD domain containing | 12017 | 0.090 | -0.1010 | No |
| 39 | IL10RA | NA | IL10RA Entrez, Source | interleukin 10 receptor, alpha | 12399 | 0.075 | -0.1143 | No |
| 40 | FGL2 | NA | FGL2 Entrez, Source | fibrinogen-like 2 | 12480 | 0.072 | -0.1166 | No |
| 41 | LILRA6 | NA | LILRA6 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 12898 | 0.057 | -0.1315 | No |
| 42 | TYMP | NA | 13693 | 0.027 | -0.1604 | No | ||
| 43 | JUNB | NA | JUNB Entrez, Source | jun B proto-oncogene | 13778 | 0.023 | -0.1633 | No |
| 44 | HCK | NA | HCK Entrez, Source | hemopoietic cell kinase | 13795 | 0.023 | -0.1637 | No |
| 45 | LILRB2 | NA | LILRB2 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | 13864 | 0.020 | -0.1660 | No |
| 46 | ACAP2 | NA | 13909 | 0.018 | -0.1675 | No | ||
| 47 | MNDA | NA | MNDA Entrez, Source | myeloid cell nuclear differentiation antigen | 14104 | 0.012 | -0.1745 | No |
| 48 | FCER1G | NA | FCER1G Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 14128 | 0.011 | -0.1752 | No |
| 49 | KRR1 | NA | KRR1 Entrez, Source | KRR1, small subunit (SSU) processome component, homolog (yeast) | 14273 | 0.005 | -0.1805 | No |
| 50 | AIF1 | NA | AIF1 Entrez, Source | allograft inflammatory factor 1 | 14416 | 0.001 | -0.1857 | No |
| 51 | IGSF6 | NA | IGSF6 Entrez, Source | immunoglobulin superfamily, member 6 | 14757 | -0.012 | -0.1981 | No |
| 52 | APOBEC3A | NA | APOBEC3A Entrez, Source | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A | 15006 | -0.021 | -0.2070 | No |
| 53 | CD1D | NA | CD1D Entrez, Source | CD1d molecule | 15044 | -0.023 | -0.2082 | No |
| 54 | LILRA2 | NA | LILRA2 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 15182 | -0.028 | -0.2130 | No |
| 55 | DPEP2 | NA | DPEP2 Entrez, Source | dipeptidase 2 | 15503 | -0.041 | -0.2244 | No |
| 56 | C20orf24 | NA | C20ORF24 Entrez, Source | chromosome 20 open reading frame 24 | 15855 | -0.054 | -0.2368 | No |
| 57 | AOAH | NA | AOAH Entrez, Source | acyloxyacyl hydrolase (neutrophil) | 16347 | -0.075 | -0.2542 | No |
| 58 | LILRB1 | NA | LILRB1 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 16826 | -0.094 | -0.2709 | No |
| 59 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 16937 | -0.099 | -0.2741 | No |
| 60 | TLR2 | NA | TLR2 Entrez, Source | toll-like receptor 2 | 17512 | -0.125 | -0.2941 | No |
| 61 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 17747 | -0.137 | -0.3014 | No |
| 62 | FCN1 | NA | FCN1 Entrez, Source | ficolin (collagen/fibrinogen domain containing) 1 | 17933 | -0.149 | -0.3069 | No |
| 63 | NAIP | NA | NAIP Entrez, Source | - | 18155 | -0.162 | -0.3136 | No |
| 64 | HCLS1 | NA | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 18598 | -0.193 | -0.3282 | No |
| 65 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 18761 | -0.207 | -0.3323 | No |
| 66 | TBXAS1 | NA | TBXAS1 Entrez, Source | thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) | 19221 | -0.246 | -0.3470 | No |
| 67 | LST1 | NA | LST1 Entrez, Source | leukocyte specific transcript 1 | 19299 | -0.251 | -0.3476 | No |
| 68 | PSTPIP1 | NA | PSTPIP1 Entrez, Source | proline-serine-threonine phosphatase interacting protein 1 | 19334 | -0.254 | -0.3467 | No |
| 69 | SH3BGRL3 | NA | SH3BGRL3 Entrez, Source | SH3 domain binding glutamic acid-rich protein like 3 | 19779 | -0.297 | -0.3604 | No |
| 70 | NCF2 | NA | NCF2 Entrez, Source | neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) | 19874 | -0.308 | -0.3611 | No |
| 71 | CYBB | NA | CYBB Entrez, Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 20252 | -0.349 | -0.3719 | No |
| 72 | FGR | NA | FGR Entrez, Source | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 20557 | -0.387 | -0.3797 | No |
| 73 | MX2 | NA | MX2 Entrez, Source | myxovirus (influenza virus) resistance 2 (mouse) | 21251 | -0.489 | -0.4009 | No |
| 74 | NOD2 | NA | 21263 | -0.491 | -0.3970 | No | ||
| 75 | SAMHD1 | NA | SAMHD1 Entrez, Source | SAM domain and HD domain 1 | 21394 | -0.513 | -0.3972 | No |
| 76 | MAP3K3 | NA | MAP3K3 Entrez, Source | mitogen-activated protein kinase kinase kinase 3 | 21567 | -0.546 | -0.3988 | No |
| 77 | SELL | NA | SELL Entrez, Source | selectin L (lymphocyte adhesion molecule 1) | 21687 | -0.568 | -0.3982 | No |
| 78 | RHOG | NA | RHOG Entrez, Source | ras homolog gene family, member G (rho G) | 22134 | -0.653 | -0.4088 | No |
| 79 | ITGAM | NA | ITGAM Entrez, Source | integrin, alpha M (complement component 3 receptor 3 subunit) | 22152 | -0.657 | -0.4037 | No |
| 80 | IQGAP1 | NA | IQGAP1 Entrez, Source | IQ motif containing GTPase activating protein 1 | 22330 | -0.693 | -0.4041 | No |
| 81 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 22932 | -0.826 | -0.4189 | Yes |
| 82 | VNN1 | NA | VNN1 Entrez, Source | vanin 1 | 23043 | -0.847 | -0.4155 | Yes |
| 83 | TKT | NA | TKT Entrez, Source | transketolase (Wernicke-Korsakoff syndrome) | 23124 | -0.863 | -0.4109 | Yes |
| 84 | USP3 | NA | USP3 Entrez, Source | ubiquitin specific peptidase 3 | 23247 | -0.891 | -0.4076 | Yes |
| 85 | ARRB2 | NA | ARRB2 Entrez, Source | arrestin, beta 2 | 23323 | -0.906 | -0.4024 | Yes |
| 86 | GMIP | NA | GMIP Entrez, Source | GEM interacting protein | 23688 | -1.003 | -0.4070 | Yes |
| 87 | MCL1 | NA | MCL1 Entrez, Source | myeloid cell leukemia sequence 1 (BCL2-related) | 23722 | -1.013 | -0.3993 | Yes |
| 88 | FAM105A | NA | FAM105A Entrez, Source | family with sequence similarity 105, member A | 23907 | -1.068 | -0.3967 | Yes |
| 89 | RIN3 | NA | RIN3 Entrez, Source | Ras and Rab interactor 3 | 23971 | -1.081 | -0.3895 | Yes |
| 90 | BST1 | NA | BST1 Entrez, Source | bone marrow stromal cell antigen 1 | 24154 | -1.136 | -0.3862 | Yes |
| 91 | CD33 | NA | CD33 Entrez, Source | CD33 molecule | 24702 | -1.310 | -0.3948 | Yes |
| 92 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 24721 | -1.317 | -0.3839 | Yes |
| 93 | DUSP1 | NA | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 24798 | -1.344 | -0.3749 | Yes |
| 94 | HSD17B11 | NA | 25014 | -1.423 | -0.3704 | Yes | ||
| 95 | ARPC1B | NA | ARPC1B Entrez, Source | actin related protein 2/3 complex, subunit 1B, 41kDa | 25503 | -1.643 | -0.3739 | Yes |
| 96 | STX11 | NA | STX11 Entrez, Source | syntaxin 11 | 25606 | -1.690 | -0.3628 | Yes |
| 97 | IER2 | NA | IER2 Entrez, Source | immediate early response 2 | 26000 | -1.916 | -0.3604 | Yes |
| 98 | PRKCD | NA | PRKCD Entrez, Source | protein kinase C, delta | 26327 | -2.150 | -0.3535 | Yes |
| 99 | CNPY3 | NA | 26363 | -2.182 | -0.3357 | Yes | ||
| 100 | TCIRG1 | NA | TCIRG1 Entrez, Source | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 26835 | -2.712 | -0.3292 | Yes |
| 101 | PLSCR1 | NA | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 26957 | -2.927 | -0.3080 | Yes |
| 102 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 26974 | -2.959 | -0.2826 | Yes |
| 103 | EVI2A | NA | EVI2A Entrez, Source | ecotropic viral integration site 2A | 27034 | -3.146 | -0.2572 | Yes |
| 104 | EVI2B | NA | EVI2B Entrez, Source | ecotropic viral integration site 2B | 27063 | -3.219 | -0.2300 | Yes |
| 105 | CHST15 | NA | 27108 | -3.403 | -0.2017 | Yes | ||
| 106 | FMNL1 | NA | FMNL1 Entrez, Source | formin-like 1 | 27118 | -3.438 | -0.1719 | Yes |
| 107 | CPPED1 | NA | 27158 | -3.571 | -0.1420 | Yes | ||
| 108 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 27181 | -3.688 | -0.1104 | Yes |
| 109 | FES | NA | FES Entrez, Source | feline sarcoma oncogene | 27245 | -4.135 | -0.0765 | Yes |
| 110 | TNFAIP2 | NA | TNFAIP2 Entrez, Source | tumor necrosis factor, alpha-induced protein 2 | 27266 | -4.266 | -0.0398 | Yes |
| 111 | PLBD1 | NA | 27318 | -4.796 | 0.0004 | Yes |
