Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | GNF2_DNM1 |
| Enrichment Score (ES) | 0.6708231 |
| Normalized Enrichment Score (NES) | 1.6876658 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.06907056 |
| FWER p-Value | 0.363 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PNMA2 | NA | PNMA2 Entrez, Source | paraneoplastic antigen MA2 | 36 | 3.757 | 0.0349 | Yes |
| 2 | NRN1 | NA | NRN1 Entrez, Source | neuritin 1 | 57 | 3.630 | 0.0692 | Yes |
| 3 | CTNND2 | NA | CTNND2 Entrez, Source | catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) | 89 | 3.511 | 0.1020 | Yes |
| 4 | MAPT | NA | MAPT Entrez, Source | microtubule-associated protein tau | 96 | 3.498 | 0.1355 | Yes |
| 5 | AMPH | NA | AMPH Entrez, Source | amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) | 217 | 3.243 | 0.1624 | Yes |
| 6 | OLFM1 | NA | OLFM1 Entrez, Source | olfactomedin 1 | 233 | 3.210 | 0.1929 | Yes |
| 7 | PSD3 | NA | PSD3 Entrez, Source | pleckstrin and Sec7 domain containing 3 | 247 | 3.182 | 0.2231 | Yes |
| 8 | NUAK1 | NA | NUAK1 Entrez, Source | NUAK family, SNF1-like kinase, 1 | 275 | 3.127 | 0.2523 | Yes |
| 9 | SYT11 | NA | SYT11 Entrez, Source | synaptotagmin XI | 360 | 2.981 | 0.2780 | Yes |
| 10 | CLIP3 | NA | 421 | 2.902 | 0.3038 | Yes | ||
| 11 | CORO2B | NA | CORO2B Entrez, Source | coronin, actin binding protein, 2B | 473 | 2.836 | 0.3293 | Yes |
| 12 | ARNT2 | NA | ARNT2 Entrez, Source | aryl-hydrocarbon receptor nuclear translocator 2 | 541 | 2.730 | 0.3532 | Yes |
| 13 | SNAP25 | NA | SNAP25 Entrez, Source | synaptosomal-associated protein, 25kDa | 546 | 2.722 | 0.3793 | Yes |
| 14 | EHD3 | NA | EHD3 Entrez, Source | EH-domain containing 3 | 576 | 2.693 | 0.4043 | Yes |
| 15 | NDRG4 | NA | NDRG4 Entrez, Source | NDRG family member 4 | 655 | 2.618 | 0.4267 | Yes |
| 16 | SV2A | NA | SV2A Entrez, Source | synaptic vesicle glycoprotein 2A | 713 | 2.560 | 0.4493 | Yes |
| 17 | CAMK2N1 | NA | CAMK2N1 Entrez, Source | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 1064 | 2.270 | 0.4584 | Yes |
| 18 | KIF5C | NA | KIF5C Entrez, Source | kinesin family member 5C | 1092 | 2.248 | 0.4791 | Yes |
| 19 | PGBD5 | NA | PGBD5 Entrez, Source | piggyBac transposable element derived 5 | 1170 | 2.196 | 0.4974 | Yes |
| 20 | TAGLN3 | NA | TAGLN3 Entrez, Source | transgelin 3 | 1188 | 2.185 | 0.5179 | Yes |
| 21 | ATP6V1G2 | NA | ATP6V1G2 Entrez, Source | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 | 1551 | 1.952 | 0.5235 | Yes |
| 22 | SLC1A3 | NA | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 1607 | 1.921 | 0.5400 | Yes |
| 23 | TSPAN7 | NA | TSPAN7 Entrez, Source | tetraspanin 7 | 1625 | 1.909 | 0.5578 | Yes |
| 24 | MAP1A | NA | MAP1A Entrez, Source | microtubule-associated protein 1A | 1665 | 1.890 | 0.5746 | Yes |
| 25 | GABBR2 | NA | GABBR2 Entrez, Source | gamma-aminobutyric acid (GABA) B receptor, 2 | 1803 | 1.821 | 0.5872 | Yes |
| 26 | FAIM2 | NA | FAIM2 Entrez, Source | Fas apoptotic inhibitory molecule 2 | 1841 | 1.805 | 0.6032 | Yes |
| 27 | YWHAH | NA | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 1869 | 1.792 | 0.6195 | Yes |
| 28 | SLC22A17 | NA | SLC22A17 Entrez, Source | solute carrier family 22 (organic cation transporter), member 17 | 2232 | 1.622 | 0.6219 | Yes |
| 29 | ARHGEF9 | NA | ARHGEF9 Entrez, Source | Cdc42 guanine nucleotide exchange factor (GEF) 9 | 2257 | 1.614 | 0.6366 | Yes |
| 30 | RAB6B | NA | RAB6B Entrez, Source | RAB6B, member RAS oncogene family | 2459 | 1.524 | 0.6440 | Yes |
| 31 | DNM1 | NA | DNM1 Entrez, Source | dynamin 1 | 2462 | 1.521 | 0.6586 | Yes |
| 32 | GAP43 | NA | GAP43 Entrez, Source | growth associated protein 43 | 2743 | 1.403 | 0.6618 | Yes |
| 33 | CAMK2B | NA | CAMK2B Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | 2960 | 1.324 | 0.6667 | Yes |
| 34 | KCNQ2 | NA | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 3310 | 1.211 | 0.6656 | Yes |
| 35 | NMNAT2 | NA | NMNAT2 Entrez, Source | nicotinamide nucleotide adenylyltransferase 2 | 3931 | 1.008 | 0.6526 | Yes |
| 36 | TYRO3 | NA | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 3976 | 0.992 | 0.6605 | Yes |
| 37 | RAB3A | NA | RAB3A Entrez, Source | RAB3A, member RAS oncogene family | 4088 | 0.962 | 0.6657 | Yes |
| 38 | CHN1 | NA | CHN1 Entrez, Source | chimerin (chimaerin) 1 | 4196 | 0.933 | 0.6708 | Yes |
| 39 | BSN | NA | BSN Entrez, Source | bassoon (presynaptic cytomatrix protein) | 5992 | 0.527 | 0.6101 | No |
| 40 | ATP2B2 | NA | ATP2B2 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 2 | 6208 | 0.496 | 0.6070 | No |
| 41 | RPH3A | NA | RPH3A Entrez, Source | rabphilin 3A homolog (mouse) | 6262 | 0.487 | 0.6097 | No |
| 42 | CAMTA1 | NA | CAMTA1 Entrez, Source | calmodulin binding transcription activator 1 | 6480 | 0.455 | 0.6061 | No |
| 43 | GDI1 | NA | GDI1 Entrez, Source | GDP dissociation inhibitor 1 | 6751 | 0.424 | 0.6003 | No |
| 44 | RUNDC3A | NA | 7643 | 0.331 | 0.5708 | No | ||
| 45 | GNG3 | NA | GNG3 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 3 | 7837 | 0.314 | 0.5668 | No |
| 46 | SH3GL2 | NA | SH3GL2 Entrez, Source | SH3-domain GRB2-like 2 | 8223 | 0.283 | 0.5554 | No |
| 47 | SULT4A1 | NA | SULT4A1 Entrez, Source | sulfotransferase family 4A, member 1 | 9698 | 0.193 | 0.5032 | No |
| 48 | CAMK2A | NA | CAMK2A Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha | 10022 | 0.178 | 0.4931 | No |
| 49 | SYN1 | NA | SYN1 Entrez, Source | synapsin I | 13172 | 0.046 | 0.3780 | No |
| 50 | GABRA1 | NA | GABRA1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 14115 | 0.011 | 0.3435 | No |
| 51 | DIRAS2 | NA | DIRAS2 Entrez, Source | DIRAS family, GTP-binding RAS-like 2 | 15437 | -0.038 | 0.2954 | No |
| 52 | VSNL1 | NA | VSNL1 Entrez, Source | visinin-like 1 | 15779 | -0.051 | 0.2834 | No |
| 53 | PREPL | NA | PREPL Entrez, Source | prolyl endopeptidase-like | 16061 | -0.062 | 0.2737 | No |
| 54 | SV2B | NA | SV2B Entrez, Source | synaptic vesicle glycoprotein 2B | 17293 | -0.115 | 0.2297 | No |
| 55 | RALYL | NA | 17456 | -0.122 | 0.2249 | No | ||
| 56 | RGS7 | NA | RGS7 Entrez, Source | regulator of G-protein signalling 7 | 17631 | -0.130 | 0.2198 | No |
| 57 | PHYHIP | NA | PHYHIP Entrez, Source | phytanoyl-CoA 2-hydroxylase interacting protein | 18659 | -0.198 | 0.1840 | No |
| 58 | SLC12A5 | NA | SLC12A5 Entrez, Source | solute carrier family 12, (potassium-chloride transporter) member 5 | 19071 | -0.233 | 0.1712 | No |
| 59 | SNCB | NA | SNCB Entrez, Source | synuclein, beta | 19574 | -0.278 | 0.1554 | No |
| 60 | FXYD7 | NA | FXYD7 Entrez, Source | FXYD domain containing ion transport regulator 7 | 20263 | -0.350 | 0.1336 | No |
| 61 | RCAN2 | NA | 20320 | -0.358 | 0.1350 | No | ||
| 62 | NPTXR | NA | NPTXR Entrez, Source | neuronal pentraxin receptor | 20743 | -0.414 | 0.1235 | No |
| 63 | CA11 | NA | CA11 Entrez, Source | carbonic anhydrase XI | 20815 | -0.424 | 0.1250 | No |
| 64 | SLC17A7 | NA | SLC17A7 Entrez, Source | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 | 21106 | -0.469 | 0.1189 | No |
| 65 | VAMP2 | NA | VAMP2 Entrez, Source | vesicle-associated membrane protein 2 (synaptobrevin 2) | 21212 | -0.482 | 0.1197 | No |
| 66 | EPB41L1 | NA | EPB41L1 Entrez, Source | erythrocyte membrane protein band 4.1-like 1 | 21842 | -0.598 | 0.1024 | No |
| 67 | ZNF365 | NA | ZNF365 Entrez, Source | zinc finger protein 365 | 22248 | -0.675 | 0.0940 | No |
| 68 | SNAP91 | NA | SNAP91 Entrez, Source | synaptosomal-associated protein, 91kDa homolog (mouse) | 24696 | -1.307 | 0.0169 | No |
| 69 | STXBP1 | NA | STXBP1 Entrez, Source | syntaxin binding protein 1 | 25687 | -1.735 | -0.0027 | No |
| 70 | SYT1 | NA | SYT1 Entrez, Source | synaptotagmin I | 26109 | -1.987 | 0.0010 | No |
| 71 | NAP1L2 | NA | NAP1L2 Entrez, Source | nucleosome assembly protein 1-like 2 | 26330 | -2.152 | 0.0137 | No |
| 72 | NAP1L3 | NA | NAP1L3 Entrez, Source | nucleosome assembly protein 1-like 3 | 26583 | -2.369 | 0.0274 | No |
