Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | GNF2_MYD88 |
| Enrichment Score (ES) | -0.5936676 |
| Normalized Enrichment Score (NES) | -1.7242388 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.079020254 |
| FWER p-Value | 0.269 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | RGS2 | NA | RGS2 Entrez, Source | regulator of G-protein signalling 2, 24kDa | 561 | 2.704 | 0.0212 | No |
| 2 | TMEM127 | NA | TMEM127 Entrez, Source | transmembrane protein 127 | 2045 | 1.700 | -0.0068 | No |
| 3 | C1orf38 | NA | C1ORF38 Entrez, Source | chromosome 1 open reading frame 38 | 3097 | 1.278 | -0.0256 | No |
| 4 | RAB8A | NA | RAB8A Entrez, Source | RAB8A, member RAS oncogene family | 3450 | 1.168 | -0.0205 | No |
| 5 | SKAP2 | NA | SKAP2 Entrez, Source | src kinase associated phosphoprotein 2 | 3810 | 1.047 | -0.0174 | No |
| 6 | PTPRE | NA | PTPRE Entrez, Source | protein tyrosine phosphatase, receptor type, E | 4129 | 0.951 | -0.0144 | No |
| 7 | FKBP15 | NA | 5208 | 0.692 | -0.0432 | No | ||
| 8 | TNFRSF1B | NA | TNFRSF1B Entrez, Source | tumor necrosis factor receptor superfamily, member 1B | 7512 | 0.343 | -0.1224 | No |
| 9 | DAZAP2 | NA | DAZAP2 Entrez, Source | DAZ associated protein 2 | 8574 | 0.258 | -0.1573 | No |
| 10 | ARPC3 | NA | ARPC3 Entrez, Source | actin related protein 2/3 complex, subunit 3, 21kDa | 8966 | 0.232 | -0.1680 | No |
| 11 | MAN2B1 | NA | MAN2B1 Entrez, Source | mannosidase, alpha, class 2B, member 1 | 9044 | 0.227 | -0.1674 | No |
| 12 | SH2B3 | NA | SH2B3 Entrez, Source | SH2B adaptor protein 3 | 9069 | 0.226 | -0.1647 | No |
| 13 | CORO1A | NA | CORO1A Entrez, Source | coronin, actin binding protein, 1A | 9074 | 0.226 | -0.1614 | No |
| 14 | TYROBP | NA | TYROBP Entrez, Source | TYRO protein tyrosine kinase binding protein | 10577 | 0.152 | -0.2141 | No |
| 15 | CMTM6 | NA | CMTM6 Entrez, Source | CKLF-like MARVEL transmembrane domain containing 6 | 10920 | 0.136 | -0.2246 | No |
| 16 | PAK2 | NA | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 11208 | 0.122 | -0.2332 | No |
| 17 | CECR1 | NA | CECR1 Entrez, Source | cat eye syndrome chromosome region, candidate 1 | 11840 | 0.096 | -0.2548 | No |
| 18 | PYCARD | NA | PYCARD Entrez, Source | PYD and CARD domain containing | 12017 | 0.090 | -0.2599 | No |
| 19 | LILRA6 | NA | LILRA6 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 12898 | 0.057 | -0.2913 | No |
| 20 | WAS | NA | WAS Entrez, Source | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 13022 | 0.052 | -0.2950 | No |
| 21 | RHOA | NA | RHOA Entrez, Source | ras homolog gene family, member A | 13179 | 0.046 | -0.3000 | No |
| 22 | DOCK2 | NA | DOCK2 Entrez, Source | dedicator of cytokinesis 2 | 13996 | 0.015 | -0.3297 | No |
| 23 | FCER1G | NA | FCER1G Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 14128 | 0.011 | -0.3343 | No |
| 24 | SELPLG | NA | SELPLG Entrez, Source | selectin P ligand | 14342 | 0.003 | -0.3421 | No |
| 25 | C20orf24 | NA | C20ORF24 Entrez, Source | chromosome 20 open reading frame 24 | 15855 | -0.054 | -0.3967 | No |
| 26 | CD53 | NA | CD53 Entrez, Source | CD53 molecule | 16512 | -0.081 | -0.4195 | No |
| 27 | CYTH4 | NA | 16767 | -0.092 | -0.4274 | No | ||
| 28 | LILRB1 | NA | LILRB1 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 16826 | -0.094 | -0.4281 | No |
| 29 | CYBA | NA | CYBA Entrez, Source | cytochrome b-245, alpha polypeptide | 17388 | -0.119 | -0.4468 | No |
| 30 | ACTR2 | NA | ACTR2 Entrez, Source | ARP2 actin-related protein 2 homolog (yeast) | 18307 | -0.173 | -0.4778 | No |
| 31 | HCLS1 | NA | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 18598 | -0.193 | -0.4854 | No |
| 32 | LST1 | NA | LST1 Entrez, Source | leukocyte specific transcript 1 | 19299 | -0.251 | -0.5072 | No |
| 33 | SH3BGRL3 | NA | SH3BGRL3 Entrez, Source | SH3 domain binding glutamic acid-rich protein like 3 | 19779 | -0.297 | -0.5202 | No |
| 34 | CAP1 | NA | CAP1 Entrez, Source | CAP, adenylate cyclase-associated protein 1 (yeast) | 20201 | -0.341 | -0.5304 | No |
| 35 | CYBB | NA | CYBB Entrez, Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 20252 | -0.349 | -0.5268 | No |
| 36 | ARPC5 | NA | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 20291 | -0.354 | -0.5227 | No |
| 37 | MX2 | NA | MX2 Entrez, Source | myxovirus (influenza virus) resistance 2 (mouse) | 21251 | -0.489 | -0.5503 | No |
| 38 | SELL | NA | SELL Entrez, Source | selectin L (lymphocyte adhesion molecule 1) | 21687 | -0.568 | -0.5575 | No |
| 39 | IQGAP1 | NA | IQGAP1 Entrez, Source | IQ motif containing GTPase activating protein 1 | 22330 | -0.693 | -0.5703 | No |
| 40 | LSP1 | NA | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 22875 | -0.812 | -0.5777 | No |
| 41 | USP3 | NA | USP3 Entrez, Source | ubiquitin specific peptidase 3 | 23247 | -0.891 | -0.5775 | No |
| 42 | GMIP | NA | GMIP Entrez, Source | GEM interacting protein | 23688 | -1.003 | -0.5782 | Yes |
| 43 | MCL1 | NA | MCL1 Entrez, Source | myeloid cell leukemia sequence 1 (BCL2-related) | 23722 | -1.013 | -0.5637 | Yes |
| 44 | RIN3 | NA | RIN3 Entrez, Source | Ras and Rab interactor 3 | 23971 | -1.081 | -0.5561 | Yes |
| 45 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 24721 | -1.317 | -0.5632 | Yes |
| 46 | ARPC1B | NA | ARPC1B Entrez, Source | actin related protein 2/3 complex, subunit 1B, 41kDa | 25503 | -1.643 | -0.5664 | Yes |
| 47 | RPS6KA1 | NA | RPS6KA1 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 25626 | -1.700 | -0.5446 | Yes |
| 48 | PRKCD | NA | PRKCD Entrez, Source | protein kinase C, delta | 26327 | -2.150 | -0.5370 | Yes |
| 49 | CNPY3 | NA | 26363 | -2.182 | -0.5045 | Yes | ||
| 50 | RNASET2 | NA | RNASET2 Entrez, Source | ribonuclease T2 | 26581 | -2.368 | -0.4759 | Yes |
| 51 | PSMB10 | NA | PSMB10 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 10 | 26623 | -2.409 | -0.4401 | Yes |
| 52 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 26685 | -2.482 | -0.4039 | Yes |
| 53 | TCIRG1 | NA | TCIRG1 Entrez, Source | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 26835 | -2.712 | -0.3675 | Yes |
| 54 | ELF4 | NA | ELF4 Entrez, Source | E74-like factor 4 (ets domain transcription factor) | 26906 | -2.819 | -0.3264 | Yes |
| 55 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 26974 | -2.959 | -0.2831 | Yes |
| 56 | LYN | NA | LYN Entrez, Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 27040 | -3.155 | -0.2367 | Yes |
| 57 | FMNL1 | NA | FMNL1 Entrez, Source | formin-like 1 | 27118 | -3.438 | -0.1864 | Yes |
| 58 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 27181 | -3.688 | -0.1316 | Yes |
| 59 | OSTF1 | NA | OSTF1 Entrez, Source | osteoclast stimulating factor 1 | 27276 | -4.343 | -0.0679 | Yes |
| 60 | STAT6 | NA | STAT6 Entrez, Source | signal transducer and activator of transcription 6, interleukin-4 induced | 27292 | -4.512 | 0.0014 | Yes |
