Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | MODULE_113 |
| Enrichment Score (ES) | 0.47787815 |
| Normalized Enrichment Score (NES) | 1.7003374 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.07543401 |
| FWER p-Value | 0.335 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MAP2 | NA | MAP2 Entrez, Source | microtubule-associated protein 2 | 54 | 3.643 | 0.0340 | Yes |
| 2 | DPP6 | NA | DPP6 Entrez, Source | dipeptidyl-peptidase 6 | 111 | 3.449 | 0.0660 | Yes |
| 3 | GPM6A | NA | GPM6A Entrez, Source | glycoprotein M6A | 168 | 3.322 | 0.0968 | Yes |
| 4 | ATP1B2 | NA | ATP1B2 Entrez, Source | ATPase, Na+/K+ transporting, beta 2 polypeptide | 176 | 3.300 | 0.1292 | Yes |
| 5 | RASL10A | NA | 250 | 3.175 | 0.1579 | Yes | ||
| 6 | NOVA1 | NA | NOVA1 Entrez, Source | neuro-oncological ventral antigen 1 | 269 | 3.137 | 0.1882 | Yes |
| 7 | PTPRO | NA | PTPRO Entrez, Source | protein tyrosine phosphatase, receptor type, O | 417 | 2.903 | 0.2115 | Yes |
| 8 | EFNB3 | NA | EFNB3 Entrez, Source | ephrin-B3 | 608 | 2.667 | 0.2309 | Yes |
| 9 | HOXB3 | NA | HOXB3 Entrez, Source | homeobox B3 | 861 | 2.424 | 0.2456 | Yes |
| 10 | GMPR | NA | GMPR Entrez, Source | guanosine monophosphate reductase | 968 | 2.335 | 0.2647 | Yes |
| 11 | DLG4 | NA | DLG4 Entrez, Source | discs, large homolog 4 (Drosophila) | 1136 | 2.221 | 0.2806 | Yes |
| 12 | AR | NA | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 1204 | 2.173 | 0.2996 | Yes |
| 13 | CRMP1 | NA | CRMP1 Entrez, Source | collapsin response mediator protein 1 | 1417 | 2.024 | 0.3118 | Yes |
| 14 | TIAM1 | NA | TIAM1 Entrez, Source | T-cell lymphoma invasion and metastasis 1 | 1428 | 2.018 | 0.3314 | Yes |
| 15 | C1orf61 | NA | C1ORF61 Entrez, Source | chromosome 1 open reading frame 61 | 1486 | 1.986 | 0.3489 | Yes |
| 16 | HAS2 | NA | HAS2 Entrez, Source | hyaluronan synthase 2 | 1487 | 1.986 | 0.3685 | Yes |
| 17 | CHN2 | NA | CHN2 Entrez, Source | chimerin (chimaerin) 2 | 1770 | 1.842 | 0.3764 | Yes |
| 18 | CBS | NA | CBS Entrez, Source | cystathionine-beta-synthase | 1812 | 1.816 | 0.3928 | Yes |
| 19 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 2266 | 1.610 | 0.3921 | Yes |
| 20 | ZIC1 | NA | ZIC1 Entrez, Source | Zic family member 1 (odd-paired homolog, Drosophila) | 2328 | 1.585 | 0.4055 | Yes |
| 21 | ZNF167 | NA | ZNF167 Entrez, Source | zinc finger protein 167 | 2413 | 1.541 | 0.4176 | Yes |
| 22 | CRABP1 | NA | CRABP1 Entrez, Source | cellular retinoic acid binding protein 1 | 2500 | 1.506 | 0.4293 | Yes |
| 23 | RGR | NA | RGR Entrez, Source | retinal G protein coupled receptor | 2537 | 1.487 | 0.4427 | Yes |
| 24 | LEPR | NA | LEPR Entrez, Source | leptin receptor | 2538 | 1.487 | 0.4574 | Yes |
| 25 | THRB | NA | THRB Entrez, Source | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) | 2695 | 1.423 | 0.4657 | Yes |
| 26 | GAP43 | NA | GAP43 Entrez, Source | growth associated protein 43 | 2743 | 1.403 | 0.4779 | Yes |
| 27 | ALDH6A1 | NA | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 3221 | 1.234 | 0.4726 | No |
| 28 | GAD1 | NA | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 3483 | 1.159 | 0.4744 | No |
| 29 | TBX2 | NA | TBX2 Entrez, Source | T-box 2 | 4136 | 0.950 | 0.4599 | No |
| 30 | CLCN4 | NA | CLCN4 Entrez, Source | chloride channel 4 | 4222 | 0.926 | 0.4659 | No |
| 31 | DRD4 | NA | DRD4 Entrez, Source | dopamine receptor D4 | 4343 | 0.897 | 0.4703 | No |
| 32 | FHL3 | NA | FHL3 Entrez, Source | four and a half LIM domains 3 | 4868 | 0.774 | 0.4587 | No |
| 33 | ALAD | NA | ALAD Entrez, Source | aminolevulinate, delta-, dehydratase | 5304 | 0.661 | 0.4493 | No |
| 34 | CENPE | NA | CENPE Entrez, Source | centromere protein E, 312kDa | 5667 | 0.584 | 0.4418 | No |
| 35 | PAH | NA | PAH Entrez, Source | phenylalanine hydroxylase | 5957 | 0.535 | 0.4364 | No |
| 36 | ATP2B2 | NA | ATP2B2 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 2 | 6208 | 0.496 | 0.4322 | No |
| 37 | SMCP | NA | SMCP Entrez, Source | sperm mitochondria-associated cysteine-rich protein | 6521 | 0.451 | 0.4251 | No |
| 38 | ABO | NA | ABO Entrez, Source | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) | 6691 | 0.430 | 0.4232 | No |
| 39 | CHRNA4 | NA | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 7267 | 0.369 | 0.4057 | No |
| 40 | CEACAM7 | NA | CEACAM7 Entrez, Source | carcinoembryonic antigen-related cell adhesion molecule 7 | 7799 | 0.318 | 0.3894 | No |
| 41 | HNF4A | NA | HNF4A Entrez, Source | hepatocyte nuclear factor 4, alpha | 8870 | 0.238 | 0.3524 | No |
| 42 | NR1I3 | NA | NR1I3 Entrez, Source | nuclear receptor subfamily 1, group I, member 3 | 8880 | 0.237 | 0.3544 | No |
| 43 | CADPS | NA | CADPS Entrez, Source | Ca2+-dependent secretion activator | 8935 | 0.234 | 0.3547 | No |
| 44 | KCNN3 | NA | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 9086 | 0.225 | 0.3514 | No |
| 45 | OMG | NA | OMG Entrez, Source | oligodendrocyte myelin glycoprotein | 9388 | 0.209 | 0.3425 | No |
| 46 | ATF6B | NA | 9539 | 0.201 | 0.3389 | No | ||
| 47 | WNT5A | NA | WNT5A Entrez, Source | wingless-type MMTV integration site family, member 5A | 9611 | 0.197 | 0.3383 | No |
| 48 | PROZ | NA | PROZ Entrez, Source | protein Z, vitamin K-dependent plasma glycoprotein | 9853 | 0.186 | 0.3313 | No |
| 49 | ZNF157 | NA | ZNF157 Entrez, Source | zinc finger protein 157 | 11171 | 0.124 | 0.2841 | No |
| 50 | FGFR3 | NA | FGFR3 Entrez, Source | fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) | 11229 | 0.122 | 0.2832 | No |
| 51 | MAG | NA | MAG Entrez, Source | myelin associated glycoprotein | 11653 | 0.104 | 0.2687 | No |
| 52 | ASGR2 | NA | ASGR2 Entrez, Source | asialoglycoprotein receptor 2 | 11670 | 0.103 | 0.2691 | No |
| 53 | GAGE1 | NA | GAGE1 Entrez, Source | G antigen 1 | 11729 | 0.100 | 0.2680 | No |
| 54 | FLT1 | NA | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 11746 | 0.100 | 0.2684 | No |
| 55 | AMELY | NA | AMELY Entrez, Source | amelogenin, Y-linked | 12059 | 0.088 | 0.2578 | No |
| 56 | TBR1 | NA | TBR1 Entrez, Source | T-box, brain, 1 | 13304 | 0.041 | 0.2125 | No |
| 57 | WNT2 | NA | WNT2 Entrez, Source | wingless-type MMTV integration site family member 2 | 13332 | 0.040 | 0.2119 | No |
| 58 | HRH1 | NA | HRH1 Entrez, Source | histamine receptor H1 | 13455 | 0.035 | 0.2078 | No |
| 59 | AMPD1 | NA | AMPD1 Entrez, Source | adenosine monophosphate deaminase 1 (isoform M) | 13663 | 0.028 | 0.2005 | No |
| 60 | UMOD | NA | UMOD Entrez, Source | uromodulin (uromucoid, Tamm-Horsfall glycoprotein) | 13753 | 0.024 | 0.1974 | No |
| 61 | PCK1 | NA | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 14017 | 0.015 | 0.1879 | No |
| 62 | KCNB1 | NA | KCNB1 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 1 | 14340 | 0.003 | 0.1761 | No |
| 63 | HSD17B2 | NA | HSD17B2 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 2 | 14388 | 0.002 | 0.1744 | No |
| 64 | KRT76 | NA | KRT76 Entrez, Source | keratin 76 | 14390 | 0.002 | 0.1744 | No |
| 65 | HRG | NA | HRG Entrez, Source | histidine-rich glycoprotein | 14436 | -0.000 | 0.1727 | No |
| 66 | PLA2G2A | NA | PLA2G2A Entrez, Source | phospholipase A2, group IIA (platelets, synovial fluid) | 14628 | -0.007 | 0.1658 | No |
| 67 | DNASE1L3 | NA | DNASE1L3 Entrez, Source | deoxyribonuclease I-like 3 | 14661 | -0.008 | 0.1647 | No |
| 68 | CLUL1 | NA | CLUL1 Entrez, Source | clusterin-like 1 (retinal) | 14663 | -0.008 | 0.1647 | No |
| 69 | IL3 | NA | IL3 Entrez, Source | interleukin 3 (colony-stimulating factor, multiple) | 14741 | -0.011 | 0.1620 | No |
| 70 | TACR3 | NA | TACR3 Entrez, Source | tachykinin receptor 3 | 14940 | -0.019 | 0.1549 | No |
| 71 | CYP2C9 | NA | CYP2C9 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 9 | 15109 | -0.026 | 0.1490 | No |
| 72 | CYP3A7 | NA | CYP3A7 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 7 | 15308 | -0.033 | 0.1421 | No |
| 73 | RRH | NA | RRH Entrez, Source | retinal pigment epithelium-derived rhodopsin homolog | 15858 | -0.054 | 0.1224 | No |
| 74 | GPA33 | NA | GPA33 Entrez, Source | glycoprotein A33 (transmembrane) | 16684 | -0.088 | 0.0930 | No |
| 75 | GLP1R | NA | GLP1R Entrez, Source | glucagon-like peptide 1 receptor | 17245 | -0.112 | 0.0735 | No |
| 76 | SLC6A4 | NA | SLC6A4 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 17580 | -0.128 | 0.0625 | No |
| 77 | RGS7 | NA | RGS7 Entrez, Source | regulator of G-protein signalling 7 | 17631 | -0.130 | 0.0620 | No |
| 78 | GPLD1 | NA | GPLD1 Entrez, Source | glycosylphosphatidylinositol specific phospholipase D1 | 17859 | -0.145 | 0.0551 | No |
| 79 | RREB1 | NA | RREB1 Entrez, Source | ras responsive element binding protein 1 | 17905 | -0.148 | 0.0549 | No |
| 80 | MMP8 | NA | MMP8 Entrez, Source | matrix metallopeptidase 8 (neutrophil collagenase) | 18410 | -0.179 | 0.0381 | No |
| 81 | OPCML | NA | OPCML Entrez, Source | opioid binding protein/cell adhesion molecule-like | 19073 | -0.233 | 0.0161 | No |
| 82 | APLP1 | NA | APLP1 Entrez, Source | amyloid beta (A4) precursor-like protein 1 | 19163 | -0.240 | 0.0152 | No |
| 83 | CBLN1 | NA | CBLN1 Entrez, Source | cerebellin 1 precursor | 19675 | -0.287 | -0.0007 | No |
| 84 | GP5 | NA | GP5 Entrez, Source | glycoprotein V (platelet) | 19695 | -0.288 | 0.0014 | No |
| 85 | ETV3 | NA | ETV3 Entrez, Source | ets variant gene 3 | 20166 | -0.338 | -0.0125 | No |
| 86 | NR1D1 | NA | NR1D1 Entrez, Source | nuclear receptor subfamily 1, group D, member 1 | 20260 | -0.350 | -0.0124 | No |
| 87 | GCG | NA | GCG Entrez, Source | glucagon | 20521 | -0.383 | -0.0182 | No |
| 88 | SERPINA6 | NA | SERPINA6 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | 20680 | -0.403 | -0.0200 | No |
| 89 | MYF6 | NA | MYF6 Entrez, Source | myogenic factor 6 (herculin) | 20857 | -0.431 | -0.0222 | No |
| 90 | ENPEP | NA | ENPEP Entrez, Source | glutamyl aminopeptidase (aminopeptidase A) | 21035 | -0.458 | -0.0242 | No |
| 91 | MAOA | NA | MAOA Entrez, Source | monoamine oxidase A | 21228 | -0.486 | -0.0265 | No |
| 92 | KRT86 | NA | KRT86 Entrez, Source | keratin 86 | 21279 | -0.494 | -0.0234 | No |
| 93 | SPTB | NA | SPTB Entrez, Source | spectrin, beta, erythrocytic (includes spherocytosis, clinical type I) | 21628 | -0.556 | -0.0307 | No |
| 94 | GHR | NA | GHR Entrez, Source | growth hormone receptor | 21667 | -0.563 | -0.0265 | No |
| 95 | SERPINB3 | NA | SERPINB3 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 23022 | -0.843 | -0.0679 | No |
| 96 | ST6GALNAC2 | NA | ST6GALNAC2 Entrez, Source | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 23478 | -0.946 | -0.0753 | No |
| 97 | ELL | NA | ELL Entrez, Source | elongation factor RNA polymerase II | 23812 | -1.042 | -0.0772 | No |
| 98 | DMD | NA | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 24692 | -1.306 | -0.0966 | No |
| 99 | MYB | NA | MYB Entrez, Source | v-myb myeloblastosis viral oncogene homolog (avian) | 24760 | -1.331 | -0.0859 | No |
| 100 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 25366 | -1.579 | -0.0926 | No |
| 101 | CTF1 | NA | CTF1 Entrez, Source | cardiotrophin 1 | 26074 | -1.962 | -0.0991 | No |
| 102 | NAP1L3 | NA | NAP1L3 Entrez, Source | nucleosome assembly protein 1-like 3 | 26583 | -2.369 | -0.0944 | No |
| 103 | ITGA3 | NA | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 26624 | -2.410 | -0.0720 | No |
| 104 | PDCD2 | NA | PDCD2 Entrez, Source | programmed cell death 2 | 26642 | -2.436 | -0.0486 | No |
| 105 | FLT4 | NA | FLT4 Entrez, Source | fms-related tyrosine kinase 4 | 26982 | -2.982 | -0.0316 | No |
| 106 | ANGPT1 | NA | ANGPT1 Entrez, Source | angiopoietin 1 | 27287 | -4.480 | 0.0015 | No |
