Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | MODULE_201 |
| Enrichment Score (ES) | 0.5059431 |
| Normalized Enrichment Score (NES) | 1.6920433 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0703766 |
| FWER p-Value | 0.356 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SSPN | NA | SSPN Entrez, Source | sarcospan (Kras oncogene-associated gene) | 180 | 3.298 | 0.0780 | Yes |
| 2 | CRYAB | NA | CRYAB Entrez, Source | crystallin, alpha B | 203 | 3.264 | 0.1609 | Yes |
| 3 | KCNH2 | NA | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 426 | 2.897 | 0.2270 | Yes |
| 4 | GJA1 | NA | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 814 | 2.462 | 0.2760 | Yes |
| 5 | MYH7 | NA | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 1433 | 2.014 | 0.3050 | Yes |
| 6 | PPP1R12B | NA | PPP1R12B Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12B | 1724 | 1.859 | 0.3420 | Yes |
| 7 | CACNG1 | NA | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 1921 | 1.765 | 0.3801 | Yes |
| 8 | CALD1 | NA | CALD1 Entrez, Source | caldesmon 1 | 2095 | 1.680 | 0.4169 | Yes |
| 9 | NEB | NA | NEB Entrez, Source | nebulin | 2765 | 1.394 | 0.4281 | Yes |
| 10 | C4B | NA | C4B Entrez, Source | complement component 4B (Childo blood group) | 2959 | 1.325 | 0.4550 | Yes |
| 11 | MYOM1 | NA | MYOM1 Entrez, Source | myomesin 1 (skelemin) 185kDa | 3500 | 1.156 | 0.4648 | Yes |
| 12 | PPP1R12A | NA | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 3519 | 1.148 | 0.4936 | Yes |
| 13 | ALDOA | NA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 3952 | 1.001 | 0.5035 | Yes |
| 14 | MYBPC2 | NA | MYBPC2 Entrez, Source | myosin binding protein C, fast type | 4968 | 0.750 | 0.4855 | Yes |
| 15 | TNNI2 | NA | TNNI2 Entrez, Source | troponin I type 2 (skeletal, fast) | 5277 | 0.669 | 0.4914 | Yes |
| 16 | MYH3 | NA | MYH3 Entrez, Source | myosin, heavy chain 3, skeletal muscle, embryonic | 5337 | 0.652 | 0.5059 | Yes |
| 17 | VIPR1 | NA | VIPR1 Entrez, Source | vasoactive intestinal peptide receptor 1 | 5757 | 0.569 | 0.5052 | No |
| 18 | CNN3 | NA | CNN3 Entrez, Source | calponin 3, acidic | 6827 | 0.415 | 0.4766 | No |
| 19 | MYL3 | NA | MYL3 Entrez, Source | myosin, light chain 3, alkali; ventricular, skeletal, slow | 9348 | 0.211 | 0.3897 | No |
| 20 | MYL1 | NA | MYL1 Entrez, Source | myosin, light chain 1, alkali; skeletal, fast | 9413 | 0.208 | 0.3927 | No |
| 21 | MYLPF | NA | MYLPF Entrez, Source | - | 10048 | 0.177 | 0.3739 | No |
| 22 | PLN | NA | PLN Entrez, Source | phospholamban | 10248 | 0.167 | 0.3709 | No |
| 23 | HRC | NA | HRC Entrez, Source | histidine rich calcium binding protein | 10320 | 0.164 | 0.3725 | No |
| 24 | ACTC1 | NA | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 11135 | 0.126 | 0.3459 | No |
| 25 | KCNA1 | NA | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 12134 | 0.085 | 0.3115 | No |
| 26 | MYL7 | NA | MYL7 Entrez, Source | myosin, light chain 7, regulatory | 12273 | 0.080 | 0.3085 | No |
| 27 | TNNT3 | NA | TNNT3 Entrez, Source | troponin T type 3 (skeletal, fast) | 12665 | 0.065 | 0.2959 | No |
| 28 | CKMT2 | NA | CKMT2 Entrez, Source | creatine kinase, mitochondrial 2 (sarcomeric) | 13511 | 0.033 | 0.2657 | No |
| 29 | SCN7A | NA | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 13567 | 0.030 | 0.2645 | No |
| 30 | NOS1 | NA | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 14403 | 0.001 | 0.2339 | No |
| 31 | KCNMB1 | NA | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 15112 | -0.026 | 0.2086 | No |
| 32 | PRKG1 | NA | PRKG1 Entrez, Source | protein kinase, cGMP-dependent, type I | 15215 | -0.030 | 0.2056 | No |
| 33 | CASQ2 | NA | CASQ2 Entrez, Source | calsequestrin 2 (cardiac muscle) | 15808 | -0.052 | 0.1853 | No |
| 34 | FKBP1B | NA | FKBP1B Entrez, Source | FK506 binding protein 1B, 12.6 kDa | 16827 | -0.094 | 0.1504 | No |
| 35 | MYH11 | NA | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 16828 | -0.094 | 0.1528 | No |
| 36 | GJA5 | NA | GJA5 Entrez, Source | gap junction protein, alpha 5, 40kDa (connexin 40) | 18191 | -0.165 | 0.1071 | No |
| 37 | RYR1 | NA | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 18403 | -0.178 | 0.1039 | No |
| 38 | SCN5A | NA | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 18543 | -0.189 | 0.1037 | No |
| 39 | FXYD1 | NA | FXYD1 Entrez, Source | FXYD domain containing ion transport regulator 1 (phospholemman) | 18692 | -0.201 | 0.1034 | No |
| 40 | ACTN3 | NA | ACTN3 Entrez, Source | actinin, alpha 3 | 18768 | -0.208 | 0.1060 | No |
| 41 | ROCK2 | NA | ROCK2 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 2 | 18780 | -0.208 | 0.1109 | No |
| 42 | EDNRA | NA | EDNRA Entrez, Source | endothelin receptor type A | 18830 | -0.212 | 0.1146 | No |
| 43 | ACTA1 | NA | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 18963 | -0.223 | 0.1155 | No |
| 44 | MYBPC1 | NA | MYBPC1 Entrez, Source | myosin binding protein C, slow type | 19575 | -0.278 | 0.1002 | No |
| 45 | MYOM2 | NA | MYOM2 Entrez, Source | myomesin (M-protein) 2, 165kDa | 21071 | -0.462 | 0.0572 | No |
| 46 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 21108 | -0.469 | 0.0679 | No |
| 47 | GNAO1 | NA | GNAO1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 23419 | -0.930 | 0.0071 | No |
| 48 | OXTR | NA | OXTR Entrez, Source | oxytocin receptor | 24892 | -1.376 | -0.0115 | No |
| 49 | FLII | NA | FLII Entrez, Source | flightless I homolog (Drosophila) | 26059 | -1.955 | -0.0042 | No |
| 50 | CHRNB1 | NA | CHRNB1 Entrez, Source | cholinergic receptor, nicotinic, beta 1 (muscle) | 26089 | -1.976 | 0.0455 | No |
