Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | MODULE_209 |
| Enrichment Score (ES) | -0.42381138 |
| Normalized Enrichment Score (NES) | -1.6851059 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.079796396 |
| FWER p-Value | 0.361 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | AEBP1 | NA | AEBP1 Entrez, Source | AE binding protein 1 | 362 | 2.980 | 0.0224 | No |
| 2 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 833 | 2.444 | 0.0343 | No |
| 3 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 1108 | 2.238 | 0.0511 | No |
| 4 | MMP2 | NA | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 1109 | 2.238 | 0.0778 | No |
| 5 | CTSO | NA | CTSO Entrez, Source | cathepsin O | 1122 | 2.232 | 0.1041 | No |
| 6 | CTSK | NA | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 1275 | 2.118 | 0.1239 | No |
| 7 | WFDC2 | NA | WFDC2 Entrez, Source | WAP four-disulfide core domain 2 | 1637 | 1.902 | 0.1334 | No |
| 8 | MST1 | NA | MST1 Entrez, Source | macrophage stimulating 1 (hepatocyte growth factor-like) | 2082 | 1.684 | 0.1372 | No |
| 9 | CAPN5 | NA | CAPN5 Entrez, Source | calpain 5 | 2485 | 1.512 | 0.1406 | No |
| 10 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 3023 | 1.303 | 0.1364 | No |
| 11 | BMP1 | NA | BMP1 Entrez, Source | bone morphogenetic protein 1 | 3679 | 1.090 | 0.1254 | No |
| 12 | IGF1 | NA | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 4165 | 0.941 | 0.1189 | No |
| 13 | FAP | NA | FAP Entrez, Source | fibroblast activation protein, alpha | 4373 | 0.889 | 0.1219 | No |
| 14 | PRSS23 | NA | PRSS23 Entrez, Source | protease, serine, 23 | 4584 | 0.844 | 0.1243 | No |
| 15 | PRSS8 | NA | PRSS8 Entrez, Source | protease, serine, 8 (prostasin) | 5806 | 0.559 | 0.0862 | No |
| 16 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 6780 | 0.420 | 0.0555 | No |
| 17 | XPNPEP1 | NA | XPNPEP1 Entrez, Source | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 7363 | 0.359 | 0.0384 | No |
| 18 | PROC | NA | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 7423 | 0.352 | 0.0405 | No |
| 19 | LIPC | NA | LIPC Entrez, Source | lipase, hepatic | 7473 | 0.346 | 0.0428 | No |
| 20 | ADAM9 | NA | ADAM9 Entrez, Source | ADAM metallopeptidase domain 9 (meltrin gamma) | 7666 | 0.329 | 0.0397 | No |
| 21 | HPN | NA | HPN Entrez, Source | hepsin (transmembrane protease, serine 1) | 7770 | 0.321 | 0.0397 | No |
| 22 | TPSAB1 | NA | TPSAB1 Entrez, Source | tryptase alpha/beta 1 | 8196 | 0.285 | 0.0276 | No |
| 23 | PROZ | NA | PROZ Entrez, Source | protein Z, vitamin K-dependent plasma glycoprotein | 9853 | 0.186 | -0.0310 | No |
| 24 | CPA3 | NA | CPA3 Entrez, Source | carboxypeptidase A3 (mast cell) | 10410 | 0.160 | -0.0495 | No |
| 25 | MMP13 | NA | MMP13 Entrez, Source | matrix metallopeptidase 13 (collagenase 3) | 10480 | 0.157 | -0.0502 | No |
| 26 | TMPRSS2 | NA | TMPRSS2 Entrez, Source | transmembrane protease, serine 2 | 10605 | 0.151 | -0.0529 | No |
| 27 | F10 | NA | F10 Entrez, Source | coagulation factor X | 11002 | 0.133 | -0.0659 | No |
| 28 | CPB2 | NA | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 11051 | 0.130 | -0.0661 | No |
| 29 | GZMB | NA | GZMB Entrez, Source | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 11501 | 0.110 | -0.0812 | No |
| 30 | NAPSA | NA | NAPSA Entrez, Source | napsin A aspartic peptidase | 11594 | 0.106 | -0.0833 | No |
| 31 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 11947 | 0.092 | -0.0951 | No |
| 32 | APOC2 | NA | APOC2 Entrez, Source | apolipoprotein C-II | 12121 | 0.086 | -0.1005 | No |
| 33 | GZMA | NA | GZMA Entrez, Source | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 12128 | 0.086 | -0.0997 | No |
| 34 | MMP3 | NA | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 12473 | 0.072 | -0.1114 | No |
| 35 | SERPINB2 | NA | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 12515 | 0.070 | -0.1121 | No |
| 36 | OLR1 | NA | OLR1 Entrez, Source | oxidised low density lipoprotein (lectin-like) receptor 1 | 12589 | 0.068 | -0.1140 | No |
| 37 | C2 | NA | C2 Entrez, Source | complement component 2 | 13410 | 0.037 | -0.1436 | No |
| 38 | GZMK | NA | GZMK Entrez, Source | granzyme K (granzyme 3; tryptase II) | 13731 | 0.025 | -0.1551 | No |
| 39 | CELA3A | NA | 13761 | 0.024 | -0.1559 | No | ||
| 40 | CPN1 | NA | CPN1 Entrez, Source | carboxypeptidase N, polypeptide 1, 50kD | 14432 | -0.000 | -0.1804 | No |
| 41 | PLA2G2A | NA | PLA2G2A Entrez, Source | phospholipase A2, group IIA (platelets, synovial fluid) | 14628 | -0.007 | -0.1875 | No |
| 42 | ACE | NA | ACE Entrez, Source | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 14808 | -0.013 | -0.1939 | No |
| 43 | APOC3 | NA | APOC3 Entrez, Source | apolipoprotein C-III | 15295 | -0.033 | -0.2114 | No |
| 44 | PRSS2 | NA | PRSS2 Entrez, Source | protease, serine, 2 (trypsin 2) | 16263 | -0.072 | -0.2460 | No |
| 45 | MMP12 | NA | MMP12 Entrez, Source | matrix metallopeptidase 12 (macrophage elastase) | 17174 | -0.109 | -0.2781 | No |
| 46 | MMP7 | NA | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 17530 | -0.126 | -0.2896 | No |
| 47 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 17747 | -0.137 | -0.2959 | No |
| 48 | LGMN | NA | LGMN Entrez, Source | legumain | 17974 | -0.152 | -0.3024 | No |
| 49 | NEDD8 | NA | NEDD8 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 8 | 18388 | -0.177 | -0.3154 | No |
| 50 | PLA2G7 | NA | PLA2G7 Entrez, Source | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | 18654 | -0.197 | -0.3228 | No |
| 51 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 19144 | -0.239 | -0.3379 | No |
| 52 | F2 | NA | F2 Entrez, Source | coagulation factor II (thrombin) | 19293 | -0.251 | -0.3403 | No |
| 53 | HP | NA | HP Entrez, Source | haptoglobin | 19578 | -0.278 | -0.3474 | No |
| 54 | PLG | NA | PLG Entrez, Source | plasminogen | 19662 | -0.286 | -0.3471 | No |
| 55 | BAAT | NA | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 19885 | -0.308 | -0.3515 | No |
| 56 | CTSE | NA | CTSE Entrez, Source | cathepsin E | 20401 | -0.368 | -0.3660 | No |
| 57 | CFB | NA | CFB Entrez, Source | complement factor B | 20904 | -0.438 | -0.3792 | No |
| 58 | ENPEP | NA | ENPEP Entrez, Source | glutamyl aminopeptidase (aminopeptidase A) | 21035 | -0.458 | -0.3785 | No |
| 59 | KLK10 | NA | KLK10 Entrez, Source | kallikrein 10 | 21141 | -0.473 | -0.3767 | No |
| 60 | CAPN2 | NA | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 21460 | -0.527 | -0.3821 | No |
| 61 | CFI | NA | CFI Entrez, Source | complement factor I | 21672 | -0.565 | -0.3830 | No |
| 62 | MMP14 | NA | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 21985 | -0.627 | -0.3870 | No |
| 63 | UBD | NA | UBD Entrez, Source | ubiquitin D | 22091 | -0.646 | -0.3831 | No |
| 64 | PGC | NA | PGC Entrez, Source | progastricsin (pepsinogen C) | 22518 | -0.733 | -0.3900 | No |
| 65 | FURIN | NA | FURIN Entrez, Source | furin (paired basic amino acid cleaving enzyme) | 23215 | -0.883 | -0.4050 | No |
| 66 | GALE | NA | GALE Entrez, Source | UDP-galactose-4-epimerase | 23729 | -1.014 | -0.4117 | Yes |
| 67 | PEPD | NA | PEPD Entrez, Source | peptidase D | 23909 | -1.068 | -0.4055 | Yes |
| 68 | TIMP1 | NA | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 24033 | -1.098 | -0.3969 | Yes |
| 69 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 24131 | -1.129 | -0.3869 | Yes |
| 70 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 24193 | -1.147 | -0.3754 | Yes |
| 71 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 24354 | -1.196 | -0.3670 | Yes |
| 72 | CTSL1 | NA | 25492 | -1.639 | -0.3891 | Yes | ||
| 73 | LAP3 | NA | LAP3 Entrez, Source | leucine aminopeptidase 3 | 25812 | -1.803 | -0.3793 | Yes |
| 74 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 25971 | -1.898 | -0.3624 | Yes |
| 75 | ANPEP | NA | ANPEP Entrez, Source | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) | 26355 | -2.176 | -0.3504 | Yes |
| 76 | GALT | NA | GALT Entrez, Source | galactose-1-phosphate uridylyltransferase | 26578 | -2.364 | -0.3302 | Yes |
| 77 | PLCG2 | NA | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 26602 | -2.383 | -0.3026 | Yes |
| 78 | CTSC | NA | CTSC Entrez, Source | cathepsin C | 26690 | -2.488 | -0.2760 | Yes |
| 79 | APOC1 | NA | APOC1 Entrez, Source | apolipoprotein C-I | 26692 | -2.488 | -0.2463 | Yes |
| 80 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 26974 | -2.959 | -0.2212 | Yes |
| 81 | SORD | NA | SORD Entrez, Source | sorbitol dehydrogenase | 26992 | -3.023 | -0.1857 | Yes |
| 82 | PSMB9 | NA | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 27011 | -3.064 | -0.1497 | Yes |
| 83 | MMP1 | NA | MMP1 Entrez, Source | matrix metallopeptidase 1 (interstitial collagenase) | 27012 | -3.065 | -0.1130 | Yes |
| 84 | LIPA | NA | LIPA Entrez, Source | lipase A, lysosomal acid, cholesterol esterase (Wolman disease) | 27072 | -3.246 | -0.0763 | Yes |
| 85 | PRDX6 | NA | PRDX6 Entrez, Source | peroxiredoxin 6 | 27086 | -3.307 | -0.0373 | Yes |
| 86 | CASP4 | NA | CASP4 Entrez, Source | caspase 4, apoptosis-related cysteine peptidase | 27208 | -3.856 | 0.0044 | Yes |
