Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | MODULE_316 |
| Enrichment Score (ES) | 0.497881 |
| Normalized Enrichment Score (NES) | 1.6836114 |
| Nominal p-value | 0.0018348624 |
| FDR q-value | 0.06302985 |
| FWER p-Value | 0.371 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MLC1 | NA | MLC1 Entrez, Source | megalencephalic leukoencephalopathy with subcortical cysts 1 | 262 | 3.151 | 0.0514 | Yes |
| 2 | GRIA3 | NA | GRIA3 Entrez, Source | glutamate receptor, ionotrophic, AMPA 3 | 408 | 2.912 | 0.1025 | Yes |
| 3 | KCNH2 | NA | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 426 | 2.897 | 0.1579 | Yes |
| 4 | GRIK3 | NA | GRIK3 Entrez, Source | glutamate receptor, ionotropic, kainate 3 | 773 | 2.497 | 0.1936 | Yes |
| 5 | KCNJ2 | NA | KCNJ2 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 2 | 1140 | 2.217 | 0.2231 | Yes |
| 6 | GRIK1 | NA | GRIK1 Entrez, Source | glutamate receptor, ionotropic, kainate 1 | 1173 | 2.195 | 0.2644 | Yes |
| 7 | KCNC3 | NA | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 1334 | 2.081 | 0.2988 | Yes |
| 8 | CACNG1 | NA | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 1921 | 1.765 | 0.3115 | Yes |
| 9 | CLCN6 | NA | CLCN6 Entrez, Source | chloride channel 6 | 1997 | 1.726 | 0.3422 | Yes |
| 10 | SCN1B | NA | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 2152 | 1.654 | 0.3686 | Yes |
| 11 | KCNJ4 | NA | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 2570 | 1.471 | 0.3817 | Yes |
| 12 | SHROOM2 | NA | SHROOM2 Entrez, Source | shroom family member 2 | 2757 | 1.397 | 0.4020 | Yes |
| 13 | ACCN2 | NA | ACCN2 Entrez, Source | amiloride-sensitive cation channel 2, neuronal | 3145 | 1.259 | 0.4121 | Yes |
| 14 | FXYD2 | NA | FXYD2 Entrez, Source | FXYD domain containing ion transport regulator 2 | 3209 | 1.236 | 0.4338 | Yes |
| 15 | CLIC2 | NA | CLIC2 Entrez, Source | chloride intracellular channel 2 | 3381 | 1.191 | 0.4506 | Yes |
| 16 | CNGA3 | NA | CNGA3 Entrez, Source | cyclic nucleotide gated channel alpha 3 | 4208 | 0.929 | 0.4382 | Yes |
| 17 | CHRNA7 | NA | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 4214 | 0.927 | 0.4560 | Yes |
| 18 | CLCN2 | NA | CLCN2 Entrez, Source | chloride channel 2 | 4410 | 0.881 | 0.4659 | Yes |
| 19 | GABRB3 | NA | GABRB3 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 4468 | 0.869 | 0.4807 | Yes |
| 20 | CACNB4 | NA | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 4738 | 0.803 | 0.4863 | Yes |
| 21 | GJB1 | NA | GJB1 Entrez, Source | gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) | 5126 | 0.714 | 0.4860 | Yes |
| 22 | AQP4 | NA | AQP4 Entrez, Source | aquaporin 4 | 5173 | 0.702 | 0.4979 | Yes |
| 23 | KCNJ12 | NA | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 5728 | 0.574 | 0.4887 | No |
| 24 | GABRA5 | NA | GABRA5 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 5 | 6170 | 0.502 | 0.4822 | No |
| 25 | CHRNA4 | NA | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 7267 | 0.369 | 0.4492 | No |
| 26 | CLCNKA | NA | CLCNKA Entrez, Source | chloride channel Ka | 7268 | 0.369 | 0.4563 | No |
| 27 | GABRR1 | NA | GABRR1 Entrez, Source | gamma-aminobutyric acid (GABA) receptor, rho 1 | 7489 | 0.345 | 0.4549 | No |
| 28 | CHRNB4 | NA | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 8139 | 0.289 | 0.4367 | No |
| 29 | AQP9 | NA | AQP9 Entrez, Source | aquaporin 9 | 8240 | 0.282 | 0.4385 | No |
| 30 | CHRNE | NA | CHRNE Entrez, Source | cholinergic receptor, nicotinic, epsilon | 10550 | 0.153 | 0.3568 | No |
| 31 | KCNE1 | NA | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 10879 | 0.138 | 0.3474 | No |
| 32 | P2RX3 | NA | P2RX3 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 3 | 11445 | 0.112 | 0.3288 | No |
| 33 | KCNB2 | NA | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 11709 | 0.102 | 0.3212 | No |
| 34 | GABRA2 | NA | GABRA2 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 12036 | 0.089 | 0.3109 | No |
| 35 | KCNK1 | NA | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 12132 | 0.085 | 0.3091 | No |
| 36 | KCNA1 | NA | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 12134 | 0.085 | 0.3107 | No |
| 37 | GRIN1 | NA | GRIN1 Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 12435 | 0.073 | 0.3011 | No |
| 38 | GJB5 | NA | GJB5 Entrez, Source | gap junction protein, beta 5 (connexin 31.1) | 12578 | 0.068 | 0.2972 | No |
| 39 | KCNJ6 | NA | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 12705 | 0.064 | 0.2938 | No |
| 40 | GLRA2 | NA | GLRA2 Entrez, Source | glycine receptor, alpha 2 | 13641 | 0.028 | 0.2601 | No |
| 41 | KCNJ3 | NA | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 13915 | 0.018 | 0.2504 | No |
| 42 | GABRA1 | NA | GABRA1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 14115 | 0.011 | 0.2433 | No |
| 43 | CLCNKB | NA | CLCNKB Entrez, Source | chloride channel Kb | 14288 | 0.004 | 0.2371 | No |
| 44 | SLC14A2 | NA | SLC14A2 Entrez, Source | solute carrier family 14 (urea transporter), member 2 | 14362 | 0.002 | 0.2345 | No |
| 45 | KCNA6 | NA | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 14751 | -0.011 | 0.2205 | No |
| 46 | GLRA3 | NA | GLRA3 Entrez, Source | glycine receptor, alpha 3 | 14944 | -0.019 | 0.2138 | No |
| 47 | KCNMB1 | NA | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 15112 | -0.026 | 0.2082 | No |
| 48 | KCNK5 | NA | KCNK5 Entrez, Source | potassium channel, subfamily K, member 5 | 15561 | -0.043 | 0.1926 | No |
| 49 | GRIK2 | NA | GRIK2 Entrez, Source | glutamate receptor, ionotropic, kainate 2 | 15758 | -0.051 | 0.1863 | No |
| 50 | MS4A2 | NA | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 15848 | -0.054 | 0.1841 | No |
| 51 | P2RX1 | NA | P2RX1 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 1 | 16433 | -0.079 | 0.1642 | No |
| 52 | GABRA6 | NA | GABRA6 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 6 | 16571 | -0.084 | 0.1608 | No |
| 53 | HTR3A | NA | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 16918 | -0.098 | 0.1500 | No |
| 54 | GABRE | NA | GABRE Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, epsilon | 17215 | -0.111 | 0.1413 | No |
| 55 | GLRA1 | NA | GLRA1 Entrez, Source | glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) | 17569 | -0.128 | 0.1308 | No |
| 56 | RYR1 | NA | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 18403 | -0.178 | 0.1037 | No |
| 57 | FXYD1 | NA | FXYD1 Entrez, Source | FXYD domain containing ion transport regulator 1 (phospholemman) | 18692 | -0.201 | 0.0971 | No |
| 58 | RYR2 | NA | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 18785 | -0.209 | 0.0977 | No |
| 59 | CHRNA2 | NA | CHRNA2 Entrez, Source | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 18918 | -0.219 | 0.0971 | No |
| 60 | GABRP | NA | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 19266 | -0.249 | 0.0892 | No |
| 61 | FXYD7 | NA | FXYD7 Entrez, Source | FXYD domain containing ion transport regulator 7 | 20263 | -0.350 | 0.0595 | No |
| 62 | KCNAB2 | NA | KCNAB2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | 21271 | -0.493 | 0.0321 | No |
| 63 | KCNJ11 | NA | KCNJ11 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 11 | 21738 | -0.579 | 0.0262 | No |
| 64 | CHRNB3 | NA | CHRNB3 Entrez, Source | cholinergic receptor, nicotinic, beta 3 | 21746 | -0.580 | 0.0372 | No |
| 65 | GJC2 | NA | 22566 | -0.744 | 0.0215 | No | ||
| 66 | SLC9A5 | NA | SLC9A5 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 5 | 23001 | -0.840 | 0.0219 | No |
| 67 | GABRD | NA | GABRD Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, delta | 23765 | -1.025 | 0.0137 | No |
| 68 | CHRNB1 | NA | CHRNB1 Entrez, Source | cholinergic receptor, nicotinic, beta 1 (muscle) | 26089 | -1.976 | -0.0332 | No |
| 69 | GABRG2 | NA | GABRG2 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 26128 | -1.999 | 0.0041 | No |
| 70 | TPTE | NA | TPTE Entrez, Source | transmembrane phosphatase with tensin homology | 26208 | -2.063 | 0.0411 | No |
