Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | MODULE_329 |
| Enrichment Score (ES) | 0.5231953 |
| Normalized Enrichment Score (NES) | 1.6799434 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.058006965 |
| FWER p-Value | 0.377 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SSPN | NA | SSPN Entrez, Source | sarcospan (Kras oncogene-associated gene) | 180 | 3.298 | 0.0684 | Yes |
| 2 | CRYAB | NA | CRYAB Entrez, Source | crystallin, alpha B | 203 | 3.264 | 0.1419 | Yes |
| 3 | AEBP1 | NA | AEBP1 Entrez, Source | AE binding protein 1 | 362 | 2.980 | 0.2039 | Yes |
| 4 | KCNH2 | NA | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 426 | 2.897 | 0.2675 | Yes |
| 5 | GJA1 | NA | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 814 | 2.462 | 0.3093 | Yes |
| 6 | MYH7 | NA | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 1433 | 2.014 | 0.3325 | Yes |
| 7 | PPP1R12B | NA | PPP1R12B Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12B | 1724 | 1.859 | 0.3641 | Yes |
| 8 | FHL1 | NA | FHL1 Entrez, Source | four and a half LIM domains 1 | 1881 | 1.788 | 0.3991 | Yes |
| 9 | CACNG1 | NA | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 1921 | 1.765 | 0.4378 | Yes |
| 10 | CALD1 | NA | CALD1 Entrez, Source | caldesmon 1 | 2095 | 1.680 | 0.4697 | Yes |
| 11 | NEB | NA | NEB Entrez, Source | nebulin | 2765 | 1.394 | 0.4769 | Yes |
| 12 | SPEG | NA | SPEG Entrez, Source | SPEG complex locus | 3387 | 1.188 | 0.4811 | Yes |
| 13 | MYOM1 | NA | MYOM1 Entrez, Source | myomesin 1 (skelemin) 185kDa | 3500 | 1.156 | 0.5033 | Yes |
| 14 | ALDOA | NA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 3952 | 1.001 | 0.5096 | Yes |
| 15 | IGF1 | NA | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 4165 | 0.941 | 0.5232 | Yes |
| 16 | TNNI2 | NA | TNNI2 Entrez, Source | troponin I type 2 (skeletal, fast) | 5277 | 0.669 | 0.4977 | No |
| 17 | MYH3 | NA | MYH3 Entrez, Source | myosin, heavy chain 3, skeletal muscle, embryonic | 5337 | 0.652 | 0.5104 | No |
| 18 | VIPR1 | NA | VIPR1 Entrez, Source | vasoactive intestinal peptide receptor 1 | 5757 | 0.569 | 0.5079 | No |
| 19 | LAMA2 | NA | LAMA2 Entrez, Source | laminin, alpha 2 (merosin, congenital muscular dystrophy) | 6206 | 0.496 | 0.5028 | No |
| 20 | ACTG2 | NA | ACTG2 Entrez, Source | actin, gamma 2, smooth muscle, enteric | 6702 | 0.428 | 0.4944 | No |
| 21 | MYL4 | NA | MYL4 Entrez, Source | myosin, light chain 4, alkali; atrial, embryonic | 8683 | 0.250 | 0.4275 | No |
| 22 | MYL1 | NA | MYL1 Entrez, Source | myosin, light chain 1, alkali; skeletal, fast | 9413 | 0.208 | 0.4055 | No |
| 23 | PLN | NA | PLN Entrez, Source | phospholamban | 10248 | 0.167 | 0.3787 | No |
| 24 | HRC | NA | HRC Entrez, Source | histidine rich calcium binding protein | 10320 | 0.164 | 0.3799 | No |
| 25 | ACTC1 | NA | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 11135 | 0.126 | 0.3529 | No |
| 26 | COL6A3 | NA | COL6A3 Entrez, Source | collagen, type VI, alpha 3 | 11184 | 0.124 | 0.3539 | No |
| 27 | ADAM12 | NA | ADAM12 Entrez, Source | ADAM metallopeptidase domain 12 (meltrin alpha) | 11530 | 0.109 | 0.3438 | No |
| 28 | MYL7 | NA | MYL7 Entrez, Source | myosin, light chain 7, regulatory | 12273 | 0.080 | 0.3184 | No |
| 29 | TNNT3 | NA | TNNT3 Entrez, Source | troponin T type 3 (skeletal, fast) | 12665 | 0.065 | 0.3055 | No |
| 30 | CKMT2 | NA | CKMT2 Entrez, Source | creatine kinase, mitochondrial 2 (sarcomeric) | 13511 | 0.033 | 0.2753 | No |
| 31 | NOS1 | NA | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 14403 | 0.001 | 0.2427 | No |
| 32 | MYOD1 | NA | MYOD1 Entrez, Source | myogenic differentiation 1 | 15732 | -0.050 | 0.1951 | No |
| 33 | CASQ2 | NA | CASQ2 Entrez, Source | calsequestrin 2 (cardiac muscle) | 15808 | -0.052 | 0.1936 | No |
| 34 | FKBP1B | NA | FKBP1B Entrez, Source | FK506 binding protein 1B, 12.6 kDa | 16827 | -0.094 | 0.1584 | No |
| 35 | MYH11 | NA | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 16828 | -0.094 | 0.1605 | No |
| 36 | CSRP3 | NA | CSRP3 Entrez, Source | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 18076 | -0.157 | 0.1184 | No |
| 37 | GJA5 | NA | GJA5 Entrez, Source | gap junction protein, alpha 5, 40kDa (connexin 40) | 18191 | -0.165 | 0.1180 | No |
| 38 | RYR1 | NA | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 18403 | -0.178 | 0.1143 | No |
| 39 | SCN5A | NA | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 18543 | -0.189 | 0.1135 | No |
| 40 | FXYD1 | NA | FXYD1 Entrez, Source | FXYD domain containing ion transport regulator 1 (phospholemman) | 18692 | -0.201 | 0.1126 | No |
| 41 | EDNRA | NA | EDNRA Entrez, Source | endothelin receptor type A | 18830 | -0.212 | 0.1124 | No |
| 42 | ACTA1 | NA | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 18963 | -0.223 | 0.1127 | No |
| 43 | MYBPC1 | NA | MYBPC1 Entrez, Source | myosin binding protein C, slow type | 19575 | -0.278 | 0.0966 | No |
| 44 | SGCG | NA | SGCG Entrez, Source | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 19775 | -0.297 | 0.0961 | No |
| 45 | FGF2 | NA | FGF2 Entrez, Source | fibroblast growth factor 2 (basic) | 20293 | -0.354 | 0.0852 | No |
| 46 | MYF6 | NA | MYF6 Entrez, Source | myogenic factor 6 (herculin) | 20857 | -0.431 | 0.0743 | No |
| 47 | MYOM2 | NA | MYOM2 Entrez, Source | myomesin (M-protein) 2, 165kDa | 21071 | -0.462 | 0.0770 | No |
| 48 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 21108 | -0.469 | 0.0864 | No |
| 49 | FLII | NA | FLII Entrez, Source | flightless I homolog (Drosophila) | 26059 | -1.955 | -0.0506 | No |
| 50 | CHRNB1 | NA | CHRNB1 Entrez, Source | cholinergic receptor, nicotinic, beta 1 (muscle) | 26089 | -1.976 | -0.0067 | No |
| 51 | ACTA2 | NA | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 26492 | -2.292 | 0.0307 | No |
