Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | ATM_DN.V1_DN |
| Enrichment Score (ES) | 0.36780667 |
| Normalized Enrichment Score (NES) | 1.6192948 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.010448854 |
| FWER p-Value | 0.08 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | NTRK2 | NA | NTRK2 Entrez, Source | neurotrophic tyrosine kinase, receptor, type 2 | 17 | 3.903 | 0.0411 | Yes |
| 2 | DNAH9 | NA | DNAH9 Entrez, Source | dynein, axonemal, heavy chain 9 | 94 | 3.503 | 0.0758 | Yes |
| 3 | RAPGEF4 | NA | RAPGEF4 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 4 | 125 | 3.409 | 0.1112 | Yes |
| 4 | PPARGC1A | NA | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 136 | 3.387 | 0.1471 | Yes |
| 5 | GRIN2D | NA | GRIN2D Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2D | 548 | 2.719 | 0.1611 | Yes |
| 6 | CYP2J2 | NA | CYP2J2 Entrez, Source | cytochrome P450, family 2, subfamily J, polypeptide 2 | 984 | 2.325 | 0.1700 | Yes |
| 7 | PLXNB1 | NA | PLXNB1 Entrez, Source | plexin B1 | 1158 | 2.207 | 0.1872 | Yes |
| 8 | MDFI | NA | MDFI Entrez, Source | MyoD family inhibitor | 1256 | 2.131 | 0.2064 | Yes |
| 9 | SEMA3A | NA | SEMA3A Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 1323 | 2.086 | 0.2263 | Yes |
| 10 | SETD4 | NA | SETD4 Entrez, Source | SET domain containing 4 | 1332 | 2.082 | 0.2483 | Yes |
| 11 | ST3GAL1 | NA | ST3GAL1 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 1368 | 2.060 | 0.2691 | Yes |
| 12 | SRPK3 | NA | SRPK3 Entrez, Source | SFRS protein kinase 3 | 1454 | 2.005 | 0.2874 | Yes |
| 13 | NLGN3 | NA | NLGN3 Entrez, Source | neuroligin 3 | 1570 | 1.940 | 0.3040 | Yes |
| 14 | ZFP36L1 | NA | ZFP36L1 Entrez, Source | zinc finger protein 36, C3H type-like 1 | 1633 | 1.905 | 0.3221 | Yes |
| 15 | BMPR2 | NA | BMPR2 Entrez, Source | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 2119 | 1.667 | 0.3221 | Yes |
| 16 | LSM5 | NA | LSM5 Entrez, Source | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 2157 | 1.652 | 0.3384 | Yes |
| 17 | MRAS | NA | MRAS Entrez, Source | muscle RAS oncogene homolog | 2405 | 1.544 | 0.3458 | Yes |
| 18 | XIAP | NA | 3111 | 1.274 | 0.3335 | Yes | ||
| 19 | WASL | NA | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 3245 | 1.226 | 0.3418 | Yes |
| 20 | TCAP | NA | TCAP Entrez, Source | titin-cap (telethonin) | 3296 | 1.216 | 0.3529 | Yes |
| 21 | CHIA | NA | CHIA Entrez, Source | chitinase, acidic | 4008 | 0.985 | 0.3373 | Yes |
| 22 | GPSM2 | NA | GPSM2 Entrez, Source | G-protein signalling modulator 2 (AGS3-like, C. elegans) | 4209 | 0.929 | 0.3399 | Yes |
| 23 | CLCN4 | NA | CLCN4 Entrez, Source | chloride channel 4 | 4222 | 0.926 | 0.3494 | Yes |
| 24 | CLEC3B | NA | CLEC3B Entrez, Source | C-type lectin domain family 3, member B | 4287 | 0.909 | 0.3567 | Yes |
| 25 | GRM8 | NA | GRM8 Entrez, Source | glutamate receptor, metabotropic 8 | 4367 | 0.891 | 0.3634 | Yes |
| 26 | PLA2G3 | NA | PLA2G3 Entrez, Source | phospholipase A2, group III | 4498 | 0.861 | 0.3678 | Yes |
| 27 | GTF2A1 | NA | GTF2A1 Entrez, Source | general transcription factor IIA, 1, 19/37kDa | 4813 | 0.785 | 0.3647 | No |
| 28 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 5178 | 0.701 | 0.3588 | No |
| 29 | HIST1H3B | NA | HIST1H3B Entrez, Source | histone cluster 1, H3b | 5322 | 0.656 | 0.3605 | No |
| 30 | CRYBA1 | NA | CRYBA1 Entrez, Source | crystallin, beta A1 | 5336 | 0.652 | 0.3670 | No |
| 31 | SLC24A2 | NA | SLC24A2 Entrez, Source | solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 | 5573 | 0.601 | 0.3648 | No |
| 32 | IL21 | NA | IL21 Entrez, Source | interleukin 21 | 6263 | 0.487 | 0.3447 | No |
| 33 | ALX3 | NA | ALX3 Entrez, Source | aristaless-like homeobox 3 | 6623 | 0.438 | 0.3362 | No |
| 34 | KCNIP2 | NA | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 6660 | 0.434 | 0.3395 | No |
| 35 | PRDM11 | NA | PRDM11 Entrez, Source | PR domain containing 11 | 6686 | 0.430 | 0.3432 | No |
| 36 | TEK | NA | TEK Entrez, Source | TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) | 6705 | 0.428 | 0.3471 | No |
| 37 | RNASE2 | NA | RNASE2 Entrez, Source | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | 6759 | 0.423 | 0.3496 | No |
| 38 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 7652 | 0.330 | 0.3204 | No |
| 39 | FMO5 | NA | FMO5 Entrez, Source | flavin containing monooxygenase 5 | 8075 | 0.294 | 0.3080 | No |
| 40 | ANGPT4 | NA | ANGPT4 Entrez, Source | angiopoietin 4 | 8255 | 0.281 | 0.3044 | No |
| 41 | LPAR3 | NA | 8355 | 0.273 | 0.3037 | No | ||
| 42 | KCNQ4 | NA | KCNQ4 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 4 | 8664 | 0.251 | 0.2951 | No |
| 43 | EDN3 | NA | EDN3 Entrez, Source | endothelin 3 | 8684 | 0.250 | 0.2970 | No |
| 44 | PPIL2 | NA | PPIL2 Entrez, Source | peptidylprolyl isomerase (cyclophilin)-like 2 | 9052 | 0.227 | 0.2860 | No |
| 45 | PLSCR2 | NA | PLSCR2 Entrez, Source | phospholipid scramblase 2 | 9113 | 0.223 | 0.2861 | No |
| 46 | PRSS21 | NA | PRSS21 Entrez, Source | protease, serine, 21 (testisin) | 9384 | 0.209 | 0.2784 | No |
| 47 | SULT1E1 | NA | SULT1E1 Entrez, Source | sulfotransferase family 1E, estrogen-preferring, member 1 | 9437 | 0.207 | 0.2787 | No |
| 48 | CSF2RB | NA | CSF2RB Entrez, Source | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 9728 | 0.192 | 0.2701 | No |
| 49 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 10197 | 0.170 | 0.2547 | No |
| 50 | POM121L9P | NA | 10409 | 0.160 | 0.2487 | No | ||
| 51 | CTRC | NA | CTRC Entrez, Source | chymotrypsin C (caldecrin) | 10445 | 0.158 | 0.2491 | No |
| 52 | ARSF | NA | ARSF Entrez, Source | arylsulfatase F | 10498 | 0.156 | 0.2489 | No |
| 53 | ADRB3 | NA | ADRB3 Entrez, Source | adrenergic, beta-3-, receptor | 10525 | 0.155 | 0.2495 | No |
| 54 | TMPRSS2 | NA | TMPRSS2 Entrez, Source | transmembrane protease, serine 2 | 10605 | 0.151 | 0.2483 | No |
| 55 | FOXB1 | NA | FOXB1 Entrez, Source | forkhead box B1 | 10773 | 0.142 | 0.2436 | No |
| 56 | IL1RAPL1 | NA | IL1RAPL1 Entrez, Source | interleukin 1 receptor accessory protein-like 1 | 10782 | 0.142 | 0.2449 | No |
| 57 | PAX1 | NA | PAX1 Entrez, Source | paired box gene 1 | 10856 | 0.139 | 0.2437 | No |
| 58 | KCNE1 | NA | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 10879 | 0.138 | 0.2443 | No |
| 59 | F10 | NA | F10 Entrez, Source | coagulation factor X | 11002 | 0.133 | 0.2413 | No |
| 60 | SSX3 | NA | SSX3 Entrez, Source | synovial sarcoma, X breakpoint 3 | 11024 | 0.131 | 0.2419 | No |
| 61 | AGXT | NA | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 11063 | 0.129 | 0.2419 | No |
| 62 | FCN2 | NA | FCN2 Entrez, Source | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) | 11174 | 0.124 | 0.2392 | No |
| 63 | KIR3DL2 | NA | KIR3DL2 Entrez, Source | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 | 11258 | 0.120 | 0.2374 | No |
| 64 | ZNF208 | NA | ZNF208 Entrez, Source | zinc finger protein 208 | 11260 | 0.120 | 0.2386 | No |
| 65 | NEUROD1 | NA | NEUROD1 Entrez, Source | neurogenic differentiation 1 | 11335 | 0.116 | 0.2372 | No |
| 66 | TAGLN | NA | TAGLN Entrez, Source | transgelin | 11571 | 0.108 | 0.2297 | No |
| 67 | MAG | NA | MAG Entrez, Source | myelin associated glycoprotein | 11653 | 0.104 | 0.2278 | No |
| 68 | AVPR1B | NA | AVPR1B Entrez, Source | arginine vasopressin receptor 1B | 11673 | 0.103 | 0.2282 | No |
| 69 | MMP27 | NA | MMP27 Entrez, Source | matrix metallopeptidase 27 | 11873 | 0.095 | 0.2219 | No |
| 70 | STK17B | NA | STK17B Entrez, Source | serine/threonine kinase 17b (apoptosis-inducing) | 11936 | 0.093 | 0.2206 | No |
| 71 | TCEB3B | NA | TCEB3B Entrez, Source | transcription elongation factor B polypeptide 3B (elongin A2) | 12261 | 0.080 | 0.2096 | No |
| 72 | HCRTR1 | NA | HCRTR1 Entrez, Source | hypocretin (orexin) receptor 1 | 12423 | 0.074 | 0.2044 | No |
| 73 | DSG3 | NA | DSG3 Entrez, Source | desmoglein 3 (pemphigus vulgaris antigen) | 12877 | 0.058 | 0.1884 | No |
| 74 | EPHA1 | NA | EPHA1 Entrez, Source | EPH receptor A1 | 13056 | 0.051 | 0.1824 | No |
| 75 | LHCGR | NA | LHCGR Entrez, Source | luteinizing hormone/choriogonadotropin receptor | 13073 | 0.050 | 0.1823 | No |
| 76 | WNT2 | NA | WNT2 Entrez, Source | wingless-type MMTV integration site family member 2 | 13332 | 0.040 | 0.1733 | No |
| 77 | HAAO | NA | HAAO Entrez, Source | 3-hydroxyanthranilate 3,4-dioxygenase | 13959 | 0.017 | 0.1504 | No |
| 78 | SCGB2A1 | NA | SCGB2A1 Entrez, Source | secretoglobin, family 2A, member 1 | 13979 | 0.016 | 0.1499 | No |
| 79 | RETN | NA | RETN Entrez, Source | resistin | 14399 | 0.001 | 0.1345 | No |
| 80 | TRPC5 | NA | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 14503 | -0.003 | 0.1307 | No |
| 81 | GPR22 | NA | GPR22 Entrez, Source | G protein-coupled receptor 22 | 14562 | -0.005 | 0.1287 | No |
| 82 | GDNF | NA | GDNF Entrez, Source | glial cell derived neurotrophic factor | 14707 | -0.010 | 0.1235 | No |
| 83 | IMPG2 | NA | IMPG2 Entrez, Source | interphotoreceptor matrix proteoglycan 2 | 14769 | -0.012 | 0.1213 | No |
| 84 | CRYGC | NA | CRYGC Entrez, Source | crystallin, gamma C | 15088 | -0.025 | 0.1099 | No |
| 85 | CD69 | NA | CD69 Entrez, Source | CD69 molecule | 15159 | -0.028 | 0.1076 | No |
| 86 | LILRA2 | NA | LILRA2 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 15182 | -0.028 | 0.1071 | No |
| 87 | GABRB2 | NA | GABRB2 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, beta 2 | 15512 | -0.041 | 0.0955 | No |
| 88 | ENTPD7 | NA | ENTPD7 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 7 | 15653 | -0.047 | 0.0908 | No |
| 89 | MS4A2 | NA | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 15848 | -0.054 | 0.0843 | No |
| 90 | ACVRL1 | NA | ACVRL1 Entrez, Source | activin A receptor type II-like 1 | 16175 | -0.068 | 0.0730 | No |
| 91 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 16249 | -0.071 | 0.0711 | No |
| 92 | RASSF9 | NA | 16780 | -0.092 | 0.0526 | No | ||
| 93 | SLC17A1 | NA | SLC17A1 Entrez, Source | solute carrier family 17 (sodium phosphate), member 1 | 16813 | -0.094 | 0.0524 | No |
| 94 | RHAG | NA | RHAG Entrez, Source | Rh-associated glycoprotein | 16834 | -0.094 | 0.0527 | No |
| 95 | LY6G6D | NA | LY6G6D Entrez, Source | lymphocyte antigen 6 complex, locus G6D | 17045 | -0.103 | 0.0461 | No |
| 96 | SLC10A2 | NA | SLC10A2 Entrez, Source | solute carrier family 10 (sodium/bile acid cotransporter family), member 2 | 17130 | -0.107 | 0.0441 | No |
| 97 | TLR7 | NA | TLR7 Entrez, Source | toll-like receptor 7 | 17470 | -0.123 | 0.0330 | No |
| 98 | TFEC | NA | TFEC Entrez, Source | transcription factor EC | 17495 | -0.124 | 0.0334 | No |
| 99 | IFI27 | NA | IFI27 Entrez, Source | interferon, alpha-inducible protein 27 | 17553 | -0.127 | 0.0327 | No |
| 100 | STX2 | NA | STX2 Entrez, Source | syntaxin 2 | 17604 | -0.129 | 0.0322 | No |
| 101 | CLEC4E | NA | CLEC4E Entrez, Source | C-type lectin domain family 4, member E | 17889 | -0.147 | 0.0233 | No |
| 102 | FCN1 | NA | FCN1 Entrez, Source | ficolin (collagen/fibrinogen domain containing) 1 | 17933 | -0.149 | 0.0233 | No |
| 103 | TSPAN32 | NA | TSPAN32 Entrez, Source | tetraspanin 32 | 18104 | -0.159 | 0.0188 | No |
| 104 | PRRG2 | NA | PRRG2 Entrez, Source | proline rich Gla (G-carboxyglutamic acid) 2 | 18252 | -0.169 | 0.0152 | No |
| 105 | CYP1A2 | NA | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 18392 | -0.178 | 0.0120 | No |
| 106 | TEX14 | NA | TEX14 Entrez, Source | testis expressed sequence 14 | 18493 | -0.185 | 0.0103 | No |
| 107 | NNAT | NA | NNAT Entrez, Source | neuronatin | 18672 | -0.199 | 0.0059 | No |
| 108 | TLL2 | NA | TLL2 Entrez, Source | tolloid-like 2 | 18910 | -0.219 | -0.0005 | No |
| 109 | GPR65 | NA | GPR65 Entrez, Source | G protein-coupled receptor 65 | 18969 | -0.224 | -0.0003 | No |
| 110 | OPCML | NA | OPCML Entrez, Source | opioid binding protein/cell adhesion molecule-like | 19073 | -0.233 | -0.0016 | No |
| 111 | CEACAM6 | NA | CEACAM6 Entrez, Source | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 19139 | -0.238 | -0.0014 | No |
| 112 | SAG | NA | SAG Entrez, Source | S-antigen; retina and pineal gland (arrestin) | 19141 | -0.238 | 0.0011 | No |
| 113 | HMHB1 | NA | HMHB1 Entrez, Source | histocompatibility (minor) HB-1 | 19322 | -0.253 | -0.0028 | No |
| 114 | HHLA2 | NA | HHLA2 Entrez, Source | HERV-H LTR-associating 2 | 19564 | -0.276 | -0.0087 | No |
| 115 | SMPX | NA | SMPX Entrez, Source | small muscle protein, X-linked | 19685 | -0.288 | -0.0100 | No |
| 116 | FBXO24 | NA | FBXO24 Entrez, Source | F-box protein 24 | 19849 | -0.305 | -0.0128 | No |
| 117 | ADCY10 | NA | 20090 | -0.330 | -0.0181 | No | ||
| 118 | CYBB | NA | CYBB Entrez, Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 20252 | -0.349 | -0.0203 | No |
| 119 | TXNRD2 | NA | TXNRD2 Entrez, Source | thioredoxin reductase 2 | 20259 | -0.350 | -0.0167 | No |
| 120 | AZI2 | NA | AZI2 Entrez, Source | 5-azacytidine induced 2 | 20551 | -0.387 | -0.0233 | No |
| 121 | ITGB4 | NA | ITGB4 Entrez, Source | integrin, beta 4 | 20612 | -0.394 | -0.0213 | No |
| 122 | PLCD1 | NA | PLCD1 Entrez, Source | phospholipase C, delta 1 | 20640 | -0.398 | -0.0180 | No |
| 123 | GPR68 | NA | GPR68 Entrez, Source | G protein-coupled receptor 68 | 20646 | -0.398 | -0.0140 | No |
| 124 | RDX | NA | RDX Entrez, Source | radixin | 20670 | -0.401 | -0.0105 | No |
| 125 | C17orf88 | NA | 21491 | -0.532 | -0.0350 | No | ||
| 126 | SPTLC2 | NA | SPTLC2 Entrez, Source | serine palmitoyltransferase, long chain base subunit 2 | 21539 | -0.541 | -0.0309 | No |
| 127 | AP4S1 | NA | AP4S1 Entrez, Source | adaptor-related protein complex 4, sigma 1 subunit | 21938 | -0.615 | -0.0390 | No |
| 128 | CCL11 | NA | CCL11 Entrez, Source | chemokine (C-C motif) ligand 11 | 21975 | -0.625 | -0.0336 | No |
| 129 | FGFBP1 | NA | FGFBP1 Entrez, Source | fibroblast growth factor binding protein 1 | 22505 | -0.732 | -0.0452 | No |
| 130 | ITPKA | NA | ITPKA Entrez, Source | inositol 1,4,5-trisphosphate 3-kinase A | 22597 | -0.753 | -0.0405 | No |
| 131 | CTAGE5 | NA | CTAGE5 Entrez, Source | CTAGE family, member 5 | 22698 | -0.773 | -0.0359 | No |
| 132 | GMIP | NA | GMIP Entrez, Source | GEM interacting protein | 23688 | -1.003 | -0.0616 | No |
| 133 | PI15 | NA | PI15 Entrez, Source | peptidase inhibitor 15 | 23943 | -1.075 | -0.0594 | No |
| 134 | SRD5A2 | NA | SRD5A2 Entrez, Source | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | 24546 | -1.259 | -0.0681 | No |
| 135 | CXCL3 | NA | CXCL3 Entrez, Source | chemokine (C-X-C motif) ligand 3 | 24820 | -1.350 | -0.0637 | No |
| 136 | KCNC4 | NA | KCNC4 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 4 | 24896 | -1.377 | -0.0517 | No |
| 137 | FER | NA | FER Entrez, Source | fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) | 25681 | -1.732 | -0.0620 | No |
| 138 | KCNG1 | NA | KCNG1 Entrez, Source | potassium voltage-gated channel, subfamily G, member 1 | 25773 | -1.778 | -0.0463 | No |
| 139 | CFH | NA | CFH Entrez, Source | complement factor H | 26651 | -2.446 | -0.0524 | No |
| 140 | MAGEA4 | NA | MAGEA4 Entrez, Source | melanoma antigen family A, 4 | 27081 | -3.285 | -0.0330 | No |
| 141 | HS3ST3B1 | NA | HS3ST3B1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 | 27222 | -3.933 | 0.0039 | No |
