Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | ATM_DN.V1_UP |
| Enrichment Score (ES) | 0.40270495 |
| Normalized Enrichment Score (NES) | 1.609707 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.009004369 |
| FWER p-Value | 0.085 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | BCHE | NA | BCHE Entrez, Source | butyrylcholinesterase | 4 | 4.147 | 0.0317 | Yes |
| 2 | COL9A3 | NA | COL9A3 Entrez, Source | collagen, type IX, alpha 3 | 38 | 3.730 | 0.0592 | Yes |
| 3 | FCGR2A | NA | FCGR2A Entrez, Source | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 61 | 3.601 | 0.0861 | Yes |
| 4 | GPR162 | NA | GPR162 Entrez, Source | G protein-coupled receptor 162 | 120 | 3.419 | 0.1102 | Yes |
| 5 | VEGFA | NA | 162 | 3.331 | 0.1343 | Yes | ||
| 6 | SOX21 | NA | SOX21 Entrez, Source | SRY (sex determining region Y)-box 21 | 189 | 3.287 | 0.1587 | Yes |
| 7 | RPE65 | NA | RPE65 Entrez, Source | retinal pigment epithelium-specific protein 65kDa | 424 | 2.898 | 0.1723 | Yes |
| 8 | NDRG4 | NA | NDRG4 Entrez, Source | NDRG family member 4 | 655 | 2.618 | 0.1840 | Yes |
| 9 | TEKT2 | NA | TEKT2 Entrez, Source | tektin 2 (testicular) | 792 | 2.479 | 0.1981 | Yes |
| 10 | IGFBP4 | NA | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 1006 | 2.314 | 0.2080 | Yes |
| 11 | ACCN4 | NA | ACCN4 Entrez, Source | amiloride-sensitive cation channel 4, pituitary | 1041 | 2.288 | 0.2244 | Yes |
| 12 | APBA2 | NA | APBA2 Entrez, Source | amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like) | 1155 | 2.209 | 0.2372 | Yes |
| 13 | GRIK1 | NA | GRIK1 Entrez, Source | glutamate receptor, ionotropic, kainate 1 | 1173 | 2.195 | 0.2535 | Yes |
| 14 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 1268 | 2.123 | 0.2663 | Yes |
| 15 | RGS12 | NA | RGS12 Entrez, Source | regulator of G-protein signalling 12 | 1292 | 2.106 | 0.2817 | Yes |
| 16 | BCL2L11 | NA | BCL2L11 Entrez, Source | BCL2-like 11 (apoptosis facilitator) | 1377 | 2.056 | 0.2944 | Yes |
| 17 | NGFR | NA | NGFR Entrez, Source | nerve growth factor receptor (TNFR superfamily, member 16) | 1617 | 1.912 | 0.3003 | Yes |
| 18 | CLCN6 | NA | CLCN6 Entrez, Source | chloride channel 6 | 1997 | 1.726 | 0.2996 | Yes |
| 19 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 2108 | 1.674 | 0.3085 | Yes |
| 20 | SRD5A1 | NA | SRD5A1 Entrez, Source | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 2366 | 1.567 | 0.3111 | Yes |
| 21 | KCNJ4 | NA | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 2570 | 1.471 | 0.3149 | Yes |
| 22 | STAG3 | NA | STAG3 Entrez, Source | stromal antigen 3 | 2603 | 1.458 | 0.3249 | Yes |
| 23 | VAV2 | NA | VAV2 Entrez, Source | vav 2 oncogene | 2728 | 1.409 | 0.3312 | Yes |
| 24 | GAB2 | NA | GAB2 Entrez, Source | GRB2-associated binding protein 2 | 2753 | 1.398 | 0.3411 | Yes |
| 25 | PLTP | NA | PLTP Entrez, Source | phospholipid transfer protein | 3006 | 1.308 | 0.3419 | Yes |
| 26 | ENO3 | NA | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 3231 | 1.232 | 0.3431 | Yes |
| 27 | CLIC2 | NA | CLIC2 Entrez, Source | chloride intracellular channel 2 | 3381 | 1.191 | 0.3468 | Yes |
| 28 | CD8A | NA | CD8A Entrez, Source | CD8a molecule | 3391 | 1.186 | 0.3556 | Yes |
| 29 | MYOM1 | NA | MYOM1 Entrez, Source | myomesin 1 (skelemin) 185kDa | 3500 | 1.156 | 0.3605 | Yes |
| 30 | P2RY1 | NA | P2RY1 Entrez, Source | purinergic receptor P2Y, G-protein coupled, 1 | 3581 | 1.128 | 0.3662 | Yes |
| 31 | NFIC | NA | NFIC Entrez, Source | nuclear factor I/C (CCAAT-binding transcription factor) | 3693 | 1.084 | 0.3705 | Yes |
| 32 | SLC6A1 | NA | SLC6A1 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, GABA), member 1 | 3765 | 1.064 | 0.3760 | Yes |
| 33 | PTK2B | NA | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 3842 | 1.037 | 0.3812 | Yes |
| 34 | EPN1 | NA | EPN1 Entrez, Source | epsin 1 | 3903 | 1.016 | 0.3868 | Yes |
| 35 | NFKBIL1 | NA | NFKBIL1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 3928 | 1.009 | 0.3937 | Yes |
| 36 | PHKG1 | NA | PHKG1 Entrez, Source | phosphorylase kinase, gamma 1 (muscle) | 4073 | 0.966 | 0.3958 | Yes |
| 37 | RAB3A | NA | RAB3A Entrez, Source | RAB3A, member RAS oncogene family | 4088 | 0.962 | 0.4027 | Yes |
| 38 | TNNC2 | NA | TNNC2 Entrez, Source | troponin C type 2 (fast) | 4681 | 0.818 | 0.3872 | No |
| 39 | N6AMT1 | NA | 4884 | 0.770 | 0.3857 | No | ||
| 40 | LIPE | NA | LIPE Entrez, Source | lipase, hormone-sensitive | 5100 | 0.721 | 0.3833 | No |
| 41 | GJB1 | NA | GJB1 Entrez, Source | gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked) | 5126 | 0.714 | 0.3879 | No |
| 42 | RECQL4 | NA | RECQL4 Entrez, Source | RecQ protein-like 4 | 5150 | 0.707 | 0.3925 | No |
| 43 | PARVA | NA | PARVA Entrez, Source | parvin, alpha | 6770 | 0.422 | 0.3362 | No |
| 44 | CHGB | NA | CHGB Entrez, Source | chromogranin B (secretogranin 1) | 6891 | 0.409 | 0.3349 | No |
| 45 | CIITA | NA | CIITA Entrez, Source | class II, major histocompatibility complex, transactivator | 7002 | 0.397 | 0.3339 | No |
| 46 | NUMB | NA | NUMB Entrez, Source | numb homolog (Drosophila) | 7179 | 0.378 | 0.3304 | No |
| 47 | TTR | NA | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 7362 | 0.359 | 0.3264 | No |
| 48 | HIST1H3F | NA | HIST1H3F Entrez, Source | histone cluster 1, H3f | 7506 | 0.343 | 0.3238 | No |
| 49 | ABCA8 | NA | ABCA8 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 8 | 7771 | 0.320 | 0.3166 | No |
| 50 | ZNF324 | NA | ZNF324 Entrez, Source | zinc finger protein 324 | 8215 | 0.284 | 0.3025 | No |
| 51 | ITIH3 | NA | ITIH3 Entrez, Source | inter-alpha (globulin) inhibitor H3 | 8315 | 0.276 | 0.3009 | No |
| 52 | TREM1 | NA | TREM1 Entrez, Source | triggering receptor expressed on myeloid cells 1 | 8419 | 0.268 | 0.2992 | No |
| 53 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 8575 | 0.258 | 0.2955 | No |
| 54 | SLC22A6 | NA | SLC22A6 Entrez, Source | solute carrier family 22 (organic anion transporter), member 6 | 8727 | 0.246 | 0.2918 | No |
| 55 | TAT | NA | TAT Entrez, Source | tyrosine aminotransferase | 8741 | 0.246 | 0.2933 | No |
| 56 | SULT1C2 | NA | SULT1C2 Entrez, Source | sulfotransferase family, cytosolic, 1C, member 2 | 8800 | 0.242 | 0.2930 | No |
| 57 | LCT | NA | LCT Entrez, Source | lactase | 8904 | 0.236 | 0.2910 | No |
| 58 | H6PD | NA | H6PD Entrez, Source | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | 9560 | 0.200 | 0.2685 | No |
| 59 | SLCO1B3 | NA | SLCO1B3 Entrez, Source | solute carrier organic anion transporter family, member 1B3 | 9915 | 0.183 | 0.2568 | No |
| 60 | TRIM31 | NA | TRIM31 Entrez, Source | tripartite motif-containing 31 | 10150 | 0.172 | 0.2496 | No |
| 61 | ACACA | NA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 10182 | 0.171 | 0.2497 | No |
| 62 | CPA3 | NA | CPA3 Entrez, Source | carboxypeptidase A3 (mast cell) | 10410 | 0.160 | 0.2426 | No |
| 63 | HSD17B3 | NA | HSD17B3 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 3 | 10829 | 0.140 | 0.2283 | No |
| 64 | PPL | NA | PPL Entrez, Source | periplakin | 11477 | 0.111 | 0.2054 | No |
| 65 | MEP1B | NA | MEP1B Entrez, Source | meprin A, beta | 11513 | 0.110 | 0.2049 | No |
| 66 | F13A1 | NA | F13A1 Entrez, Source | coagulation factor XIII, A1 polypeptide | 11523 | 0.110 | 0.2054 | No |
| 67 | HSD3B2 | NA | HSD3B2 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | 11646 | 0.104 | 0.2018 | No |
| 68 | FLT1 | NA | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 11746 | 0.100 | 0.1989 | No |
| 69 | CD19 | NA | CD19 Entrez, Source | CD19 molecule | 12503 | 0.071 | 0.1716 | No |
| 70 | TNNT3 | NA | TNNT3 Entrez, Source | troponin T type 3 (skeletal, fast) | 12665 | 0.065 | 0.1662 | No |
| 71 | CAV3 | NA | CAV3 Entrez, Source | caveolin 3 | 12740 | 0.062 | 0.1640 | No |
| 72 | CYP24A1 | NA | CYP24A1 Entrez, Source | cytochrome P450, family 24, subfamily A, polypeptide 1 | 12759 | 0.062 | 0.1638 | No |
| 73 | CCR10 | NA | CCR10 Entrez, Source | chemokine (C-C motif) receptor 10 | 12792 | 0.061 | 0.1631 | No |
| 74 | SYN1 | NA | SYN1 Entrez, Source | synapsin I | 13172 | 0.046 | 0.1495 | No |
| 75 | NDST4 | NA | NDST4 Entrez, Source | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 | 13242 | 0.043 | 0.1473 | No |
| 76 | GLRA2 | NA | GLRA2 Entrez, Source | glycine receptor, alpha 2 | 13641 | 0.028 | 0.1329 | No |
| 77 | ADAM18 | NA | ADAM18 Entrez, Source | ADAM metallopeptidase domain 18 | 13840 | 0.021 | 0.1257 | No |
| 78 | C15orf2 | NA | C15ORF2 Entrez, Source | chromosome 15 open reading frame 2 | 14601 | -0.006 | 0.0978 | No |
| 79 | ZNF214 | NA | ZNF214 Entrez, Source | zinc finger protein 214 | 14855 | -0.015 | 0.0886 | No |
| 80 | NPC1L1 | NA | NPC1L1 Entrez, Source | NPC1 (Niemann-Pick disease, type C1, gene)-like 1 | 15004 | -0.021 | 0.0834 | No |
| 81 | CYP2C9 | NA | CYP2C9 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 9 | 15109 | -0.026 | 0.0797 | No |
| 82 | GAPDHS | NA | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 15183 | -0.028 | 0.0773 | No |
| 83 | PRODH2 | NA | PRODH2 Entrez, Source | proline dehydrogenase (oxidase) 2 | 15265 | -0.032 | 0.0745 | No |
| 84 | GDF2 | NA | GDF2 Entrez, Source | growth differentiation factor 2 | 15278 | -0.032 | 0.0743 | No |
| 85 | GHRHR | NA | GHRHR Entrez, Source | growth hormone releasing hormone receptor | 15734 | -0.050 | 0.0580 | No |
| 86 | GKN1 | NA | GKN1 Entrez, Source | gastrokine 1 | 15828 | -0.053 | 0.0550 | No |
| 87 | SLC5A2 | NA | SLC5A2 Entrez, Source | solute carrier family 5 (sodium/glucose cotransporter), member 2 | 15910 | -0.056 | 0.0524 | No |
| 88 | PROL1 | NA | PROL1 Entrez, Source | proline rich, lacrimal 1 | 16269 | -0.072 | 0.0398 | No |
| 89 | CSF3R | NA | CSF3R Entrez, Source | colony stimulating factor 3 receptor (granulocyte) | 16429 | -0.079 | 0.0346 | No |
| 90 | BDKRB1 | NA | BDKRB1 Entrez, Source | bradykinin receptor B1 | 16675 | -0.088 | 0.0262 | No |
| 91 | DNAI1 | NA | DNAI1 Entrez, Source | dynein, axonemal, intermediate chain 1 | 16951 | -0.099 | 0.0169 | No |
| 92 | XCL1 | NA | XCL1 Entrez, Source | chemokine (C motif) ligand 1 | 16956 | -0.099 | 0.0175 | No |
| 93 | CEBPE | NA | CEBPE Entrez, Source | CCAAT/enhancer binding protein (C/EBP), epsilon | 17079 | -0.105 | 0.0138 | No |
| 94 | CA6 | NA | CA6 Entrez, Source | carbonic anhydrase VI | 17134 | -0.107 | 0.0126 | No |
| 95 | CYP4F3 | NA | CYP4F3 Entrez, Source | cytochrome P450, family 4, subfamily F, polypeptide 3 | 17205 | -0.111 | 0.0109 | No |
| 96 | XAF1 | NA | 17404 | -0.120 | 0.0046 | No | ||
| 97 | LIM2 | NA | LIM2 Entrez, Source | lens intrinsic membrane protein 2, 19kDa | 17405 | -0.120 | 0.0055 | No |
| 98 | GCM1 | NA | GCM1 Entrez, Source | glial cells missing homolog 1 (Drosophila) | 17736 | -0.137 | -0.0056 | No |
| 99 | CLDN14 | NA | CLDN14 Entrez, Source | claudin 14 | 17779 | -0.139 | -0.0061 | No |
| 100 | ECM2 | NA | ECM2 Entrez, Source | extracellular matrix protein 2, female organ and adipocyte specific | 18069 | -0.157 | -0.0155 | No |
| 101 | TXK | NA | TXK Entrez, Source | TXK tyrosine kinase | 18164 | -0.163 | -0.0177 | No |
| 102 | DYSF | NA | DYSF Entrez, Source | dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) | 18409 | -0.179 | -0.0253 | No |
| 103 | ABCG5 | NA | ABCG5 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) | 18420 | -0.180 | -0.0243 | No |
| 104 | PSG5 | NA | PSG5 Entrez, Source | pregnancy specific beta-1-glycoprotein 5 | 18658 | -0.198 | -0.0315 | No |
| 105 | KRT85 | NA | KRT85 Entrez, Source | keratin 85 | 19153 | -0.239 | -0.0478 | No |
| 106 | SNCB | NA | SNCB Entrez, Source | synuclein, beta | 19574 | -0.278 | -0.0611 | No |
| 107 | AKAP5 | NA | AKAP5 Entrez, Source | A kinase (PRKA) anchor protein 5 | 19611 | -0.282 | -0.0603 | No |
| 108 | BEST1 | NA | 19768 | -0.297 | -0.0637 | No | ||
| 109 | CRHR2 | NA | CRHR2 Entrez, Source | corticotropin releasing hormone receptor 2 | 20059 | -0.327 | -0.0719 | No |
| 110 | CLIC5 | NA | CLIC5 Entrez, Source | chloride intracellular channel 5 | 20738 | -0.413 | -0.0937 | No |
| 111 | HPR | NA | HPR Entrez, Source | haptoglobin-related protein | 20926 | -0.441 | -0.0971 | No |
| 112 | SARDH | NA | SARDH Entrez, Source | sarcosine dehydrogenase | 21033 | -0.458 | -0.0975 | No |
| 113 | QTRT1 | NA | QTRT1 Entrez, Source | queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase) | 21131 | -0.472 | -0.0975 | No |
| 114 | LHPP | NA | LHPP Entrez, Source | - | 21528 | -0.539 | -0.1079 | No |
| 115 | EFNA1 | NA | EFNA1 Entrez, Source | ephrin-A1 | 21707 | -0.572 | -0.1100 | No |
| 116 | TRAF1 | NA | TRAF1 Entrez, Source | TNF receptor-associated factor 1 | 21969 | -0.624 | -0.1148 | No |
| 117 | ICAM5 | NA | ICAM5 Entrez, Source | intercellular adhesion molecule 5, telencephalin | 22164 | -0.659 | -0.1169 | No |
| 118 | S100A3 | NA | S100A3 Entrez, Source | S100 calcium binding protein A3 | 22326 | -0.692 | -0.1175 | No |
| 119 | LHB | NA | LHB Entrez, Source | luteinizing hormone beta polypeptide | 22695 | -0.772 | -0.1251 | No |
| 120 | CRHR1 | NA | CRHR1 Entrez, Source | corticotropin releasing hormone receptor 1 | 22759 | -0.786 | -0.1214 | No |
| 121 | RET | NA | RET Entrez, Source | ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) | 23677 | -1.000 | -0.1474 | No |
| 122 | PARP3 | NA | PARP3 Entrez, Source | poly (ADP-ribose) polymerase family, member 3 | 23742 | -1.017 | -0.1419 | No |
| 123 | IL24 | NA | IL24 Entrez, Source | interleukin 24 | 23921 | -1.070 | -0.1403 | No |
| 124 | TIAM2 | NA | TIAM2 Entrez, Source | T-cell lymphoma invasion and metastasis 2 | 23995 | -1.087 | -0.1346 | No |
| 125 | PDE6G | NA | PDE6G Entrez, Source | phosphodiesterase 6G, cGMP-specific, rod, gamma | 24156 | -1.136 | -0.1317 | No |
| 126 | HRK | NA | HRK Entrez, Source | harakiri, BCL2 interacting protein (contains only BH3 domain) | 24327 | -1.188 | -0.1288 | No |
| 127 | MYL2 | NA | MYL2 Entrez, Source | myosin, light chain 2, regulatory, cardiac, slow | 24618 | -1.282 | -0.1297 | No |
| 128 | ADARB1 | NA | ADARB1 Entrez, Source | adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) | 24902 | -1.380 | -0.1295 | No |
| 129 | FSTL3 | NA | FSTL3 Entrez, Source | follistatin-like 3 (secreted glycoprotein) | 25008 | -1.420 | -0.1224 | No |
| 130 | SPAG4 | NA | SPAG4 Entrez, Source | sperm associated antigen 4 | 25206 | -1.505 | -0.1181 | No |
| 131 | ULBP2 | NA | ULBP2 Entrez, Source | UL16 binding protein 2 | 25295 | -1.546 | -0.1094 | No |
| 132 | S100A2 | NA | S100A2 Entrez, Source | S100 calcium binding protein A2 | 25589 | -1.682 | -0.1073 | No |
| 133 | SIPA1 | NA | SIPA1 Entrez, Source | signal-induced proliferation-associated gene 1 | 26147 | -2.020 | -0.1122 | No |
| 134 | FGF5 | NA | FGF5 Entrez, Source | fibroblast growth factor 5 | 26408 | -2.218 | -0.1047 | No |
| 135 | REL | NA | REL Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 26476 | -2.276 | -0.0897 | No |
| 136 | DLX6 | NA | DLX6 Entrez, Source | distal-less homeobox 6 | 26641 | -2.435 | -0.0770 | No |
| 137 | ZNF215 | NA | ZNF215 Entrez, Source | zinc finger protein 215 | 26848 | -2.747 | -0.0635 | No |
| 138 | SLC7A5 | NA | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 26946 | -2.902 | -0.0447 | No |
| 139 | BDNF | NA | BDNF Entrez, Source | brain-derived neurotrophic factor | 27006 | -3.055 | -0.0234 | No |
| 140 | ME3 | NA | ME3 Entrez, Source | malic enzyme 3, NADP(+)-dependent, mitochondrial | 27298 | -4.582 | 0.0011 | No |
