Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | BMI1_DN.V1_DN |
| Enrichment Score (ES) | 0.50474507 |
| Normalized Enrichment Score (NES) | 1.6165402 |
| Nominal p-value | 0.004115226 |
| FDR q-value | 0.009091553 |
| FWER p-Value | 0.081 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | FOS | NA | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 3 | 4.177 | 0.0218 | Yes |
| 2 | COL9A3 | NA | COL9A3 Entrez, Source | collagen, type IX, alpha 3 | 38 | 3.730 | 0.0401 | Yes |
| 3 | C1orf54 | NA | C1ORF54 Entrez, Source | chromosome 1 open reading frame 54 | 85 | 3.528 | 0.0569 | Yes |
| 4 | SSBP2 | NA | SSBP2 Entrez, Source | single-stranded DNA binding protein 2 | 110 | 3.450 | 0.0741 | Yes |
| 5 | GPR162 | NA | GPR162 Entrez, Source | G protein-coupled receptor 162 | 120 | 3.419 | 0.0917 | Yes |
| 6 | PPARGC1A | NA | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 136 | 3.387 | 0.1089 | Yes |
| 7 | PDE4B | NA | PDE4B Entrez, Source | phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | 147 | 3.365 | 0.1262 | Yes |
| 8 | DOK5 | NA | DOK5 Entrez, Source | docking protein 5 | 153 | 3.346 | 0.1435 | Yes |
| 9 | ID4 | NA | ID4 Entrez, Source | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 172 | 3.304 | 0.1602 | Yes |
| 10 | SSPN | NA | SSPN Entrez, Source | sarcospan (Kras oncogene-associated gene) | 180 | 3.298 | 0.1772 | Yes |
| 11 | PNMAL1 | NA | 200 | 3.272 | 0.1937 | Yes | ||
| 12 | HOXB13 | NA | HOXB13 Entrez, Source | homeobox B13 | 288 | 3.103 | 0.2067 | Yes |
| 13 | VAV3 | NA | VAV3 Entrez, Source | vav 3 oncogene | 319 | 3.047 | 0.2216 | Yes |
| 14 | NDRG2 | NA | NDRG2 Entrez, Source | NDRG family member 2 | 320 | 3.045 | 0.2376 | Yes |
| 15 | IFI44L | NA | IFI44L Entrez, Source | interferon-induced protein 44-like | 322 | 3.045 | 0.2535 | Yes |
| 16 | SOX2 | NA | SOX2 Entrez, Source | SRY (sex determining region Y)-box 2 | 342 | 3.009 | 0.2686 | Yes |
| 17 | CLIP3 | NA | 421 | 2.902 | 0.2809 | Yes | ||
| 18 | METTL7A | NA | METTL7A Entrez, Source | methyltransferase like 7A | 433 | 2.889 | 0.2956 | Yes |
| 19 | EPHA4 | NA | EPHA4 Entrez, Source | EPH receptor A4 | 459 | 2.861 | 0.3097 | Yes |
| 20 | SEPP1 | NA | SEPP1 Entrez, Source | selenoprotein P, plasma, 1 | 479 | 2.830 | 0.3238 | Yes |
| 21 | ETV1 | NA | ETV1 Entrez, Source | ets variant gene 1 | 615 | 2.660 | 0.3328 | Yes |
| 22 | GTF2I | NA | GTF2I Entrez, Source | general transcription factor II, i | 689 | 2.587 | 0.3437 | Yes |
| 23 | GAS2 | NA | GAS2 Entrez, Source | growth arrest-specific 2 | 810 | 2.465 | 0.3522 | Yes |
| 24 | ARHGAP12 | NA | ARHGAP12 Entrez, Source | Rho GTPase activating protein 12 | 829 | 2.447 | 0.3644 | Yes |
| 25 | CTNNBIP1 | NA | CTNNBIP1 Entrez, Source | catenin, beta interacting protein 1 | 845 | 2.437 | 0.3766 | Yes |
| 26 | PEG3 | NA | PEG3 Entrez, Source | paternally expressed 3 | 886 | 2.400 | 0.3877 | Yes |
| 27 | CITED1 | NA | CITED1 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | 1002 | 2.316 | 0.3956 | Yes |
| 28 | CHL1 | NA | CHL1 Entrez, Source | cell adhesion molecule with homology to L1CAM (close homolog of L1) | 1309 | 2.095 | 0.3954 | Yes |
| 29 | DCTN6 | NA | DCTN6 Entrez, Source | dynactin 6 | 1378 | 2.055 | 0.4036 | Yes |
| 30 | BST2 | NA | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 1430 | 2.017 | 0.4123 | Yes |
| 31 | KCNJ16 | NA | KCNJ16 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 16 | 1471 | 1.995 | 0.4213 | Yes |
| 32 | SH3BGRL | NA | SH3BGRL Entrez, Source | SH3 domain binding glutamic acid-rich protein like | 1527 | 1.962 | 0.4296 | Yes |
| 33 | WFDC2 | NA | WFDC2 Entrez, Source | WAP four-disulfide core domain 2 | 1637 | 1.902 | 0.4355 | Yes |
| 34 | HS6ST1 | NA | HS6ST1 Entrez, Source | heparan sulfate 6-O-sulfotransferase 1 | 1658 | 1.894 | 0.4447 | Yes |
| 35 | CA2 | NA | CA2 Entrez, Source | carbonic anhydrase II | 1735 | 1.854 | 0.4517 | Yes |
| 36 | PLEKHA4 | NA | PLEKHA4 Entrez, Source | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 1763 | 1.843 | 0.4603 | Yes |
| 37 | TRPS1 | NA | TRPS1 Entrez, Source | trichorhinophalangeal syndrome I | 1890 | 1.780 | 0.4650 | Yes |
| 38 | HIST1H4H | NA | HIST1H4H Entrez, Source | histone cluster 1, H4h | 2133 | 1.663 | 0.4648 | Yes |
| 39 | EFHD1 | NA | EFHD1 Entrez, Source | EF-hand domain family, member D1 | 2376 | 1.561 | 0.4641 | Yes |
| 40 | TMEM176B | NA | TMEM176B Entrez, Source | transmembrane protein 176B | 2498 | 1.506 | 0.4676 | Yes |
| 41 | PID1 | NA | 2913 | 1.345 | 0.4594 | Yes | ||
| 42 | HIST2H2BE | NA | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 2976 | 1.318 | 0.4640 | Yes |
| 43 | CREM | NA | CREM Entrez, Source | cAMP responsive element modulator | 3043 | 1.296 | 0.4684 | Yes |
| 44 | PCDH8 | NA | PCDH8 Entrez, Source | protocadherin 8 | 3119 | 1.269 | 0.4723 | Yes |
| 45 | NENF | NA | NENF Entrez, Source | neuron derived neurotrophic factor | 3184 | 1.247 | 0.4765 | Yes |
| 46 | GPX3 | NA | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 3278 | 1.220 | 0.4794 | Yes |
| 47 | DYNLT3 | NA | DYNLT3 Entrez, Source | dynein, light chain, Tctex-type 3 | 3297 | 1.215 | 0.4851 | Yes |
| 48 | SNX4 | NA | SNX4 Entrez, Source | sorting nexin 4 | 3298 | 1.215 | 0.4915 | Yes |
| 49 | ZNF423 | NA | ZNF423 Entrez, Source | zinc finger protein 423 | 3454 | 1.167 | 0.4919 | Yes |
| 50 | GAS7 | NA | GAS7 Entrez, Source | growth arrest-specific 7 | 3520 | 1.148 | 0.4956 | Yes |
| 51 | TRIM2 | NA | TRIM2 Entrez, Source | tripartite motif-containing 2 | 3879 | 1.024 | 0.4878 | Yes |
| 52 | TRAPPC6A | NA | TRAPPC6A Entrez, Source | trafficking protein particle complex 6A | 3925 | 1.011 | 0.4914 | Yes |
| 53 | NMNAT2 | NA | NMNAT2 Entrez, Source | nicotinamide nucleotide adenylyltransferase 2 | 3931 | 1.008 | 0.4965 | Yes |
| 54 | COL4A3BP | NA | COL4A3BP Entrez, Source | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein | 4063 | 0.969 | 0.4968 | Yes |
| 55 | ETFB | NA | ETFB Entrez, Source | electron-transfer-flavoprotein, beta polypeptide | 4202 | 0.931 | 0.4966 | Yes |
| 56 | IFITM1 | NA | IFITM1 Entrez, Source | interferon induced transmembrane protein 1 (9-27) | 4366 | 0.891 | 0.4952 | Yes |
| 57 | TMEM176A | NA | TMEM176A Entrez, Source | transmembrane protein 176A | 4393 | 0.884 | 0.4989 | Yes |
| 58 | SEMA3E | NA | SEMA3E Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 4517 | 0.857 | 0.4989 | Yes |
| 59 | PRPH | NA | PRPH Entrez, Source | peripherin | 4547 | 0.851 | 0.5023 | Yes |
| 60 | PCP4 | NA | PCP4 Entrez, Source | Purkinje cell protein 4 | 4601 | 0.842 | 0.5047 | Yes |
| 61 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 4940 | 0.757 | 0.4963 | No |
| 62 | FLJ42627 | NA | FLJ42627 Entrez, Source | - | 5453 | 0.628 | 0.4807 | No |
| 63 | C2orf27A | NA | 5648 | 0.588 | 0.4767 | No | ||
| 64 | KIAA1310 | NA | 5950 | 0.537 | 0.4684 | No | ||
| 65 | GPD1L | NA | GPD1L Entrez, Source | glycerol-3-phosphate dehydrogenase 1-like | 5970 | 0.533 | 0.4705 | No |
| 66 | S100A4 | NA | S100A4 Entrez, Source | S100 calcium binding protein A4 | 6035 | 0.521 | 0.4709 | No |
| 67 | MSRB2 | NA | MSRB2 Entrez, Source | methionine sulfoxide reductase B2 | 6203 | 0.497 | 0.4674 | No |
| 68 | TNP1 | NA | TNP1 Entrez, Source | transition protein 1 (during histone to protamine replacement) | 6288 | 0.483 | 0.4668 | No |
| 69 | WDR25 | NA | WDR25 Entrez, Source | WD repeat domain 25 | 6387 | 0.469 | 0.4657 | No |
| 70 | DPYD | NA | DPYD Entrez, Source | dihydropyrimidine dehydrogenase | 6599 | 0.441 | 0.4602 | No |
| 71 | TRAF3IP2 | NA | TRAF3IP2 Entrez, Source | TRAF3 interacting protein 2 | 6749 | 0.424 | 0.4569 | No |
| 72 | HIST1H3G | NA | HIST1H3G Entrez, Source | histone cluster 1, H3g | 6977 | 0.400 | 0.4507 | No |
| 73 | MGC2889 | NA | MGC2889 Entrez, Source | - | 6978 | 0.400 | 0.4528 | No |
| 74 | ABHD8 | NA | ABHD8 Entrez, Source | abhydrolase domain containing 8 | 7251 | 0.371 | 0.4447 | No |
| 75 | GPR88 | NA | GPR88 Entrez, Source | G protein-coupled receptor 88 | 7382 | 0.357 | 0.4418 | No |
| 76 | PRDX2 | NA | PRDX2 Entrez, Source | peroxiredoxin 2 | 7779 | 0.320 | 0.4289 | No |
| 77 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 8714 | 0.247 | 0.3959 | No |
| 78 | TCEAL2 | NA | TCEAL2 Entrez, Source | transcription elongation factor A (SII)-like 2 | 8803 | 0.241 | 0.3939 | No |
| 79 | ESRP1 | NA | 8900 | 0.236 | 0.3916 | No | ||
| 80 | MYH13 | NA | MYH13 Entrez, Source | myosin, heavy chain 13, skeletal muscle | 8953 | 0.233 | 0.3909 | No |
| 81 | MAOB | NA | MAOB Entrez, Source | monoamine oxidase B | 9285 | 0.215 | 0.3799 | No |
| 82 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 9841 | 0.186 | 0.3604 | No |
| 83 | TSPO | NA | TSPO Entrez, Source | translocator protein (18kDa) | 10024 | 0.178 | 0.3547 | No |
| 84 | BRCC3 | NA | BRCC3 Entrez, Source | BRCA1/BRCA2-containing complex, subunit 3 | 10095 | 0.174 | 0.3530 | No |
| 85 | SLPI | NA | SLPI Entrez, Source | secretory leukocyte peptidase inhibitor | 10226 | 0.168 | 0.3491 | No |
| 86 | FAM76A | NA | FAM76A Entrez, Source | family with sequence similarity 76, member A | 10893 | 0.138 | 0.3253 | No |
| 87 | KLF15 | NA | KLF15 Entrez, Source | Kruppel-like factor 15 | 11348 | 0.116 | 0.3092 | No |
| 88 | ALX4 | NA | ALX4 Entrez, Source | aristaless-like homeobox 4 | 13362 | 0.039 | 0.2354 | No |
| 89 | SCNN1A | NA | SCNN1A Entrez, Source | sodium channel, nonvoltage-gated 1 alpha | 13451 | 0.035 | 0.2323 | No |
| 90 | ARHGAP15 | NA | ARHGAP15 Entrez, Source | Rho GTPase activating protein 15 | 14093 | 0.012 | 0.2088 | No |
| 91 | GTF2A1L | NA | 15724 | -0.049 | 0.1491 | No | ||
| 92 | LECT1 | NA | LECT1 Entrez, Source | leukocyte cell derived chemotaxin 1 | 15777 | -0.051 | 0.1475 | No |
| 93 | SLC17A6 | NA | SLC17A6 Entrez, Source | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 | 15850 | -0.054 | 0.1451 | No |
| 94 | TP63 | NA | 15864 | -0.054 | 0.1449 | No | ||
| 95 | PLAC4 | NA | PLAC4 Entrez, Source | placenta-specific 4 | 16126 | -0.065 | 0.1357 | No |
| 96 | LMO3 | NA | LMO3 Entrez, Source | LIM domain only 3 (rhombotin-like 2) | 16466 | -0.080 | 0.1236 | No |
| 97 | CCKAR | NA | CCKAR Entrez, Source | cholecystokinin A receptor | 16682 | -0.088 | 0.1162 | No |
| 98 | STON1 | NA | STON1 Entrez, Source | stonin 1 | 16900 | -0.097 | 0.1087 | No |
| 99 | TFF2 | NA | TFF2 Entrez, Source | trefoil factor 2 (spasmolytic protein 1) | 17043 | -0.103 | 0.1040 | No |
| 100 | PDCD4 | NA | PDCD4 Entrez, Source | programmed cell death 4 (neoplastic transformation inhibitor) | 17060 | -0.104 | 0.1040 | No |
| 101 | IFI27 | NA | IFI27 Entrez, Source | interferon, alpha-inducible protein 27 | 17553 | -0.127 | 0.0865 | No |
| 102 | TEX14 | NA | TEX14 Entrez, Source | testis expressed sequence 14 | 18493 | -0.185 | 0.0530 | No |
| 103 | CDH22 | NA | CDH22 Entrez, Source | cadherin-like 22 | 18597 | -0.193 | 0.0502 | No |
| 104 | WNT16 | NA | WNT16 Entrez, Source | wingless-type MMTV integration site family, member 16 | 19151 | -0.239 | 0.0311 | No |
| 105 | CTAG1A | NA | CTAG1A Entrez, Source | cancer/testis antigen 1A | 19211 | -0.245 | 0.0302 | No |
| 106 | CES1 | NA | CES1 Entrez, Source | carboxylesterase 1 (monocyte/macrophage serine esterase 1) | 19568 | -0.277 | 0.0186 | No |
| 107 | SIM1 | NA | SIM1 Entrez, Source | single-minded homolog 1 (Drosophila) | 19952 | -0.315 | 0.0062 | No |
| 108 | SUCLG2 | NA | SUCLG2 Entrez, Source | succinate-CoA ligase, GDP-forming, beta subunit | 20223 | -0.344 | -0.0020 | No |
| 109 | CLDN16 | NA | CLDN16 Entrez, Source | claudin 16 | 20246 | -0.348 | -0.0010 | No |
| 110 | TTC33 | NA | TTC33 Entrez, Source | tetratricopeptide repeat domain 33 | 20419 | -0.370 | -0.0053 | No |
| 111 | SFXN1 | NA | SFXN1 Entrez, Source | sideroflexin 1 | 20464 | -0.376 | -0.0050 | No |
| 112 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 20792 | -0.421 | -0.0148 | No |
| 113 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 20994 | -0.451 | -0.0198 | No |
| 114 | LANCL1 | NA | LANCL1 Entrez, Source | LanC lantibiotic synthetase component C-like 1 (bacterial) | 21626 | -0.556 | -0.0401 | No |
| 115 | PRPF6 | NA | PRPF6 Entrez, Source | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 21779 | -0.587 | -0.0426 | No |
| 116 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 21809 | -0.594 | -0.0406 | No |
| 117 | LPAR2 | NA | 22257 | -0.679 | -0.0535 | No | ||
| 118 | API5 | NA | API5 Entrez, Source | apoptosis inhibitor 5 | 22332 | -0.694 | -0.0526 | No |
| 119 | PADI2 | NA | PADI2 Entrez, Source | peptidyl arginine deiminase, type II | 22773 | -0.789 | -0.0646 | No |
| 120 | CYP11A1 | NA | CYP11A1 Entrez, Source | cytochrome P450, family 11, subfamily A, polypeptide 1 | 22993 | -0.839 | -0.0683 | No |
| 121 | CAB39 | NA | CAB39 Entrez, Source | calcium binding protein 39 | 22997 | -0.839 | -0.0640 | No |
| 122 | TSPAN1 | NA | TSPAN1 Entrez, Source | tetraspanin 1 | 23502 | -0.951 | -0.0775 | No |
| 123 | CHMP2B | NA | CHMP2B Entrez, Source | chromatin modifying protein 2B | 23563 | -0.969 | -0.0747 | No |
| 124 | TFAP2A | NA | TFAP2A Entrez, Source | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 23640 | -0.991 | -0.0723 | No |
| 125 | BLVRB | NA | BLVRB Entrez, Source | biliverdin reductase B (flavin reductase (NADPH)) | 23893 | -1.062 | -0.0760 | No |
| 126 | BMI1 | NA | BMI1 Entrez, Source | B lymphoma Mo-MLV insertion region (mouse) | 23952 | -1.077 | -0.0725 | No |
| 127 | MSX2 | NA | MSX2 Entrez, Source | msh homeobox homolog 2 (Drosophila) | 24841 | -1.357 | -0.0980 | No |
| 128 | DDX60 | NA | 24864 | -1.366 | -0.0917 | No | ||
| 129 | SNAI1 | NA | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 25400 | -1.593 | -0.1030 | No |
| 130 | EIF4B | NA | EIF4B Entrez, Source | eukaryotic translation initiation factor 4B | 25595 | -1.686 | -0.1013 | No |
| 131 | DNAJC12 | NA | DNAJC12 Entrez, Source | DnaJ (Hsp40) homolog, subfamily C, member 12 | 25713 | -1.746 | -0.0964 | No |
| 132 | IFI6 | NA | IFI6 Entrez, Source | interferon, alpha-inducible protein 6 | 25912 | -1.862 | -0.0940 | No |
| 133 | MVP | NA | MVP Entrez, Source | major vault protein | 26105 | -1.983 | -0.0906 | No |
| 134 | PDE5A | NA | PDE5A Entrez, Source | phosphodiesterase 5A, cGMP-specific | 26369 | -2.191 | -0.0888 | No |
| 135 | EEF1A2 | NA | EEF1A2 Entrez, Source | eukaryotic translation elongation factor 1 alpha 2 | 26472 | -2.272 | -0.0806 | No |
| 136 | ISOC1 | NA | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 26725 | -2.534 | -0.0766 | No |
| 137 | SOCS2 | NA | SOCS2 Entrez, Source | suppressor of cytokine signaling 2 | 26833 | -2.703 | -0.0664 | No |
| 138 | PLS1 | NA | PLS1 Entrez, Source | plastin 1 (I isoform) | 26911 | -2.826 | -0.0544 | No |
| 139 | C17orf59 | NA | C17ORF59 Entrez, Source | chromosome 17 open reading frame 59 | 26922 | -2.858 | -0.0398 | No |
| 140 | IL1R1 | NA | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 26964 | -2.933 | -0.0259 | No |
| 141 | TNNT1 | NA | TNNT1 Entrez, Source | troponin T type 1 (skeletal, slow) | 27044 | -3.163 | -0.0123 | No |
| 142 | EGR1 | NA | EGR1 Entrez, Source | early growth response 1 | 27274 | -4.330 | 0.0020 | No |
