Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | BMI1_DN.V1_UP |
| Enrichment Score (ES) | -0.33368358 |
| Normalized Enrichment Score (NES) | -1.3887373 |
| Nominal p-value | 0.010080645 |
| FDR q-value | 0.14031501 |
| FWER p-Value | 0.552 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | C8orf4 | NA | C8ORF4 Entrez, Source | chromosome 8 open reading frame 4 | 24 | 3.833 | 0.0194 | No |
| 2 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 130 | 3.400 | 0.0336 | No |
| 3 | LRIG1 | NA | LRIG1 Entrez, Source | leucine-rich repeats and immunoglobulin-like domains 1 | 137 | 3.386 | 0.0514 | No |
| 4 | CD97 | NA | CD97 Entrez, Source | CD97 molecule | 187 | 3.291 | 0.0670 | No |
| 5 | LSAMP | NA | LSAMP Entrez, Source | limbic system-associated membrane protein | 325 | 3.039 | 0.0781 | No |
| 6 | CSPG5 | NA | CSPG5 Entrez, Source | chondroitin sulfate proteoglycan 5 (neuroglycan C) | 326 | 3.035 | 0.0942 | No |
| 7 | CSPG4 | NA | CSPG4 Entrez, Source | chondroitin sulfate proteoglycan 4 (melanoma-associated) | 366 | 2.976 | 0.1085 | No |
| 8 | ITGB8 | NA | ITGB8 Entrez, Source | integrin, beta 8 | 394 | 2.934 | 0.1231 | No |
| 9 | TMEM51 | NA | TMEM51 Entrez, Source | transmembrane protein 51 | 440 | 2.881 | 0.1367 | No |
| 10 | CXCR7 | NA | CXCR7 Entrez, Source | chemokine (C-X-C motif) receptor 7 | 520 | 2.766 | 0.1485 | No |
| 11 | LEPREL2 | NA | LEPREL2 Entrez, Source | leprecan-like 2 | 691 | 2.587 | 0.1560 | No |
| 12 | TRIO | NA | TRIO Entrez, Source | triple functional domain (PTPRF interacting) | 702 | 2.574 | 0.1693 | No |
| 13 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 718 | 2.553 | 0.1822 | No |
| 14 | FJX1 | NA | FJX1 Entrez, Source | four jointed box 1 (Drosophila) | 759 | 2.512 | 0.1941 | No |
| 15 | POMT2 | NA | POMT2 Entrez, Source | protein-O-mannosyltransferase 2 | 815 | 2.462 | 0.2051 | No |
| 16 | FGFR1 | NA | FGFR1 Entrez, Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 828 | 2.448 | 0.2177 | No |
| 17 | TNFAIP6 | NA | TNFAIP6 Entrez, Source | tumor necrosis factor, alpha-induced protein 6 | 885 | 2.401 | 0.2283 | No |
| 18 | CHST3 | NA | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 1242 | 2.138 | 0.2266 | No |
| 19 | COL16A1 | NA | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 1355 | 2.070 | 0.2335 | No |
| 20 | HAS2 | NA | HAS2 Entrez, Source | hyaluronan synthase 2 | 1487 | 1.986 | 0.2392 | No |
| 21 | MMP15 | NA | MMP15 Entrez, Source | matrix metallopeptidase 15 (membrane-inserted) | 1663 | 1.892 | 0.2428 | No |
| 22 | AGRN | NA | 1912 | 1.773 | 0.2430 | No | ||
| 23 | SLC2A1 | NA | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 2185 | 1.639 | 0.2417 | No |
| 24 | PLXNA2 | NA | PLXNA2 Entrez, Source | plexin A2 | 2581 | 1.470 | 0.2350 | No |
| 25 | CHST11 | NA | CHST11 Entrez, Source | carbohydrate (chondroitin 4) sulfotransferase 11 | 2709 | 1.419 | 0.2379 | No |
| 26 | COL7A1 | NA | COL7A1 Entrez, Source | collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) | 2844 | 1.369 | 0.2402 | No |
| 27 | SIRPA | NA | SIRPA Entrez, Source | signal-regulatory protein alpha | 2956 | 1.326 | 0.2431 | No |
| 28 | TIMP3 | NA | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 3182 | 1.247 | 0.2415 | No |
| 29 | CD82 | NA | CD82 Entrez, Source | CD82 molecule | 3224 | 1.233 | 0.2465 | No |
| 30 | ITGA5 | NA | ITGA5 Entrez, Source | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 3226 | 1.233 | 0.2530 | No |
| 31 | SRPX2 | NA | SRPX2 Entrez, Source | sushi-repeat-containing protein, X-linked 2 | 3318 | 1.208 | 0.2561 | No |
| 32 | PAPPA | NA | PAPPA Entrez, Source | pregnancy-associated plasma protein A, pappalysin 1 | 3627 | 1.107 | 0.2506 | No |
| 33 | ABCA1 | NA | ABCA1 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 1 | 3667 | 1.094 | 0.2550 | No |
| 34 | STX1A | NA | STX1A Entrez, Source | syntaxin 1A (brain) | 3789 | 1.055 | 0.2561 | No |
| 35 | EDN1 | NA | EDN1 Entrez, Source | endothelin 1 | 3804 | 1.049 | 0.2612 | No |
| 36 | MFGE8 | NA | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 4030 | 0.978 | 0.2581 | No |
| 37 | PODXL | NA | PODXL Entrez, Source | podocalyxin-like | 4123 | 0.952 | 0.2597 | No |
| 38 | HAPLN1 | NA | HAPLN1 Entrez, Source | hyaluronan and proteoglycan link protein 1 | 4331 | 0.900 | 0.2569 | No |
| 39 | FAP | NA | FAP Entrez, Source | fibroblast activation protein, alpha | 4373 | 0.889 | 0.2601 | No |
| 40 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 4383 | 0.886 | 0.2645 | No |
| 41 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4414 | 0.880 | 0.2680 | No |
| 42 | B4GALNT1 | NA | B4GALNT1 Entrez, Source | beta-1,4-N-acetyl-galactosaminyl transferase 1 | 4609 | 0.840 | 0.2654 | No |
| 43 | HBEGF | NA | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 4667 | 0.821 | 0.2676 | No |
| 44 | FKRP | NA | FKRP Entrez, Source | fukutin related protein | 4799 | 0.789 | 0.2670 | No |
| 45 | FZD5 | NA | FZD5 Entrez, Source | frizzled homolog 5 (Drosophila) | 5003 | 0.742 | 0.2635 | No |
| 46 | SLCO2A1 | NA | SLCO2A1 Entrez, Source | solute carrier organic anion transporter family, member 2A1 | 5343 | 0.651 | 0.2544 | No |
| 47 | NOV | NA | NOV Entrez, Source | nephroblastoma overexpressed gene | 6037 | 0.520 | 0.2317 | No |
| 48 | BMP5 | NA | BMP5 Entrez, Source | bone morphogenetic protein 5 | 6101 | 0.511 | 0.2321 | No |
| 49 | TEK | NA | TEK Entrez, Source | TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) | 6705 | 0.428 | 0.2122 | No |
| 50 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 6780 | 0.420 | 0.2117 | No |
| 51 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 6852 | 0.412 | 0.2113 | No |
| 52 | HOXB1 | NA | HOXB1 Entrez, Source | homeobox B1 | 7353 | 0.359 | 0.1948 | No |
| 53 | MLL | NA | MLL Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) | 7425 | 0.351 | 0.1940 | No |
| 54 | ITGB6 | NA | ITGB6 Entrez, Source | integrin, beta 6 | 7762 | 0.321 | 0.1834 | No |
| 55 | CRISPLD2 | NA | CRISPLD2 Entrez, Source | cysteine-rich secretory protein LCCL domain containing 2 | 7821 | 0.316 | 0.1829 | No |
| 56 | FOXP3 | NA | FOXP3 Entrez, Source | forkhead box P3 | 8420 | 0.268 | 0.1624 | No |
| 57 | SLC2A6 | NA | SLC2A6 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 6 | 8458 | 0.265 | 0.1624 | No |
| 58 | SLC1A4 | NA | SLC1A4 Entrez, Source | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 9440 | 0.206 | 0.1274 | No |
| 59 | CTNS | NA | CTNS Entrez, Source | cystinosis, nephropathic | 9456 | 0.206 | 0.1279 | No |
| 60 | KRT17 | NA | KRT17 Entrez, Source | keratin 17 | 9619 | 0.197 | 0.1230 | No |
| 61 | CPA4 | NA | CPA4 Entrez, Source | carboxypeptidase A4 | 10050 | 0.176 | 0.1082 | No |
| 62 | MFAP5 | NA | MFAP5 Entrez, Source | microfibrillar associated protein 5 | 10872 | 0.138 | 0.0787 | No |
| 63 | LTBP4 | NA | LTBP4 Entrez, Source | latent transforming growth factor beta binding protein 4 | 11330 | 0.116 | 0.0625 | No |
| 64 | ADAM12 | NA | ADAM12 Entrez, Source | ADAM metallopeptidase domain 12 (meltrin alpha) | 11530 | 0.109 | 0.0558 | No |
| 65 | TAGLN | NA | TAGLN Entrez, Source | transgelin | 11571 | 0.108 | 0.0549 | No |
| 66 | CLSPN | NA | CLSPN Entrez, Source | claspin homolog (Xenopus laevis) | 11664 | 0.103 | 0.0520 | No |
| 67 | LCP1 | NA | LCP1 Entrez, Source | lymphocyte cytosolic protein 1 (L-plastin) | 11683 | 0.103 | 0.0519 | No |
| 68 | INHBA | NA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 11814 | 0.097 | 0.0476 | No |
| 69 | CCL20 | NA | CCL20 Entrez, Source | chemokine (C-C motif) ligand 20 | 12374 | 0.076 | 0.0275 | No |
| 70 | MMP3 | NA | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 12473 | 0.072 | 0.0242 | No |
| 71 | C2CD2L | NA | 13542 | 0.032 | -0.0149 | No | ||
| 72 | ANXA3 | NA | ANXA3 Entrez, Source | annexin A3 | 13631 | 0.028 | -0.0180 | No |
| 73 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 13873 | 0.019 | -0.0267 | No |
| 74 | GDF5 | NA | GDF5 Entrez, Source | growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) | 14866 | -0.016 | -0.0631 | No |
| 75 | GAL | NA | GAL Entrez, Source | galanin | 15232 | -0.030 | -0.0764 | No |
| 76 | FAM57A | NA | FAM57A Entrez, Source | family with sequence similarity 57, member A | 15271 | -0.032 | -0.0776 | No |
| 77 | FGF21 | NA | FGF21 Entrez, Source | fibroblast growth factor 21 | 15291 | -0.033 | -0.0781 | No |
| 78 | CSF2 | NA | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 16165 | -0.067 | -0.1099 | No |
| 79 | GABRE | NA | GABRE Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, epsilon | 17215 | -0.111 | -0.1479 | No |
| 80 | EPHA2 | NA | EPHA2 Entrez, Source | EPH receptor A2 | 17523 | -0.125 | -0.1585 | No |
| 81 | MMP7 | NA | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 17530 | -0.126 | -0.1581 | No |
| 82 | PMEPA1 | NA | 17548 | -0.126 | -0.1580 | No | ||
| 83 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 17747 | -0.137 | -0.1646 | No |
| 84 | PROP1 | NA | PROP1 Entrez, Source | prophet of Pit1, paired-like homeodomain transcription factor | 17749 | -0.137 | -0.1639 | No |
| 85 | TIE1 | NA | TIE1 Entrez, Source | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 17892 | -0.147 | -0.1683 | No |
| 86 | PSG5 | NA | PSG5 Entrez, Source | pregnancy specific beta-1-glycoprotein 5 | 18658 | -0.198 | -0.1954 | No |
| 87 | GREM1 | NA | GREM1 Entrez, Source | gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) | 18865 | -0.215 | -0.2019 | No |
| 88 | LRRC15 | NA | LRRC15 Entrez, Source | leucine rich repeat containing 15 | 18945 | -0.222 | -0.2036 | No |
| 89 | GPR172A | NA | GPR172A Entrez, Source | G protein-coupled receptor 172A | 19626 | -0.283 | -0.2271 | No |
| 90 | TNFRSF8 | NA | TNFRSF8 Entrez, Source | tumor necrosis factor receptor superfamily, member 8 | 19904 | -0.310 | -0.2357 | No |
| 91 | TNFRSF9 | NA | TNFRSF9 Entrez, Source | tumor necrosis factor receptor superfamily, member 9 | 21018 | -0.456 | -0.2742 | No |
| 92 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 21108 | -0.469 | -0.2750 | No |
| 93 | PDCD1LG2 | NA | PDCD1LG2 Entrez, Source | programmed cell death 1 ligand 2 | 21180 | -0.478 | -0.2750 | No |
| 94 | STC2 | NA | STC2 Entrez, Source | stanniocalcin 2 | 21227 | -0.485 | -0.2742 | No |
| 95 | SEMA3G | NA | SEMA3G Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | 21347 | -0.506 | -0.2758 | No |
| 96 | VLDLR | NA | VLDLR Entrez, Source | very low density lipoprotein receptor | 21561 | -0.545 | -0.2808 | No |
| 97 | LHFPL2 | NA | LHFPL2 Entrez, Source | lipoma HMGIC fusion partner-like 2 | 22154 | -0.657 | -0.2991 | No |
| 98 | NT5E | NA | NT5E Entrez, Source | 5'-nucleotidase, ecto (CD73) | 22231 | -0.672 | -0.2983 | No |
| 99 | TMEM62 | NA | TMEM62 Entrez, Source | transmembrane protein 62 | 22376 | -0.701 | -0.2999 | No |
| 100 | DHRS3 | NA | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 22386 | -0.704 | -0.2965 | No |
| 101 | SLC19A1 | NA | SLC19A1 Entrez, Source | solute carrier family 19 (folate transporter), member 1 | 22643 | -0.763 | -0.3019 | No |
| 102 | SLC5A6 | NA | SLC5A6 Entrez, Source | solute carrier family 5 (sodium-dependent vitamin transporter), member 6 | 22930 | -0.825 | -0.3080 | No |
| 103 | VNN1 | NA | VNN1 Entrez, Source | vanin 1 | 23043 | -0.847 | -0.3076 | No |
| 104 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 23140 | -0.867 | -0.3066 | No |
| 105 | FURIN | NA | FURIN Entrez, Source | furin (paired basic amino acid cleaving enzyme) | 23215 | -0.883 | -0.3046 | No |
| 106 | NRP2 | NA | NRP2 Entrez, Source | neuropilin 2 | 23738 | -1.017 | -0.3184 | No |
| 107 | BST1 | NA | BST1 Entrez, Source | bone marrow stromal cell antigen 1 | 24154 | -1.136 | -0.3277 | Yes |
| 108 | COL13A1 | NA | COL13A1 Entrez, Source | collagen, type XIII, alpha 1 | 24159 | -1.138 | -0.3218 | Yes |
| 109 | ATF6 | NA | ATF6 Entrez, Source | activating transcription factor 6 | 24198 | -1.147 | -0.3171 | Yes |
| 110 | LRP5 | NA | LRP5 Entrez, Source | low density lipoprotein receptor-related protein 5 | 24383 | -1.206 | -0.3175 | Yes |
| 111 | BMP4 | NA | BMP4 Entrez, Source | bone morphogenetic protein 4 | 24438 | -1.222 | -0.3130 | Yes |
| 112 | FLNB | NA | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 24557 | -1.265 | -0.3106 | Yes |
| 113 | LAMB3 | NA | LAMB3 Entrez, Source | laminin, beta 3 | 24588 | -1.273 | -0.3049 | Yes |
| 114 | INHBE | NA | INHBE Entrez, Source | inhibin, beta E | 24647 | -1.293 | -0.3002 | Yes |
| 115 | SLC29A1 | NA | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 24888 | -1.374 | -0.3018 | Yes |
| 116 | KCNC4 | NA | KCNC4 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 4 | 24896 | -1.377 | -0.2947 | Yes |
| 117 | ASPH | NA | ASPH Entrez, Source | aspartate beta-hydroxylase | 24917 | -1.385 | -0.2881 | Yes |
| 118 | ATP13A2 | NA | ATP13A2 Entrez, Source | ATPase type 13A2 | 25190 | -1.497 | -0.2902 | Yes |
| 119 | PANX1 | NA | PANX1 Entrez, Source | pannexin 1 | 25578 | -1.678 | -0.2955 | Yes |
| 120 | FADS3 | NA | FADS3 Entrez, Source | fatty acid desaturase 3 | 25715 | -1.747 | -0.2912 | Yes |
| 121 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 25740 | -1.759 | -0.2828 | Yes |
| 122 | CXCL1 | NA | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 25823 | -1.806 | -0.2762 | Yes |
| 123 | SLCO4A1 | NA | SLCO4A1 Entrez, Source | solute carrier organic anion transporter family, member 4A1 | 25930 | -1.874 | -0.2702 | Yes |
| 124 | GPRC5A | NA | GPRC5A Entrez, Source | G protein-coupled receptor, family C, group 5, member A | 26007 | -1.920 | -0.2628 | Yes |
| 125 | TNFSF9 | NA | TNFSF9 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 9 | 26008 | -1.921 | -0.2526 | Yes |
| 126 | LIF | NA | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 26070 | -1.959 | -0.2445 | Yes |
| 127 | CLDN1 | NA | CLDN1 Entrez, Source | claudin 1 | 26211 | -2.067 | -0.2386 | Yes |
| 128 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 26352 | -2.173 | -0.2323 | Yes |
| 129 | ANPEP | NA | ANPEP Entrez, Source | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) | 26355 | -2.176 | -0.2208 | Yes |
| 130 | ACTA2 | NA | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 26492 | -2.292 | -0.2136 | Yes |
| 131 | MICB | NA | MICB Entrez, Source | MHC class I polypeptide-related sequence B | 26520 | -2.314 | -0.2024 | Yes |
| 132 | ITGA3 | NA | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 26624 | -2.410 | -0.1934 | Yes |
| 133 | PTHLH | NA | PTHLH Entrez, Source | parathyroid hormone-like hormone | 26693 | -2.489 | -0.1827 | Yes |
| 134 | VANGL1 | NA | VANGL1 Entrez, Source | vang-like 1 (van gogh, Drosophila) | 26782 | -2.613 | -0.1720 | Yes |
| 135 | MICA | NA | MICA Entrez, Source | MHC class I polypeptide-related sequence A | 26889 | -2.797 | -0.1611 | Yes |
| 136 | SLC7A5 | NA | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 26946 | -2.902 | -0.1478 | Yes |
| 137 | SLC29A2 | NA | SLC29A2 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 2 | 26988 | -3.010 | -0.1333 | Yes |
| 138 | SLC1A5 | NA | SLC1A5 Entrez, Source | solute carrier family 1 (neutral amino acid transporter), member 5 | 27061 | -3.213 | -0.1189 | Yes |
| 139 | ADRB2 | NA | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 27138 | -3.500 | -0.1032 | Yes |
| 140 | GFPT2 | NA | GFPT2 Entrez, Source | glutamine-fructose-6-phosphate transaminase 2 | 27142 | -3.513 | -0.0846 | Yes |
| 141 | FES | NA | FES Entrez, Source | feline sarcoma oncogene | 27245 | -4.135 | -0.0665 | Yes |
| 142 | DKK1 | NA | DKK1 Entrez, Source | dickkopf homolog 1 (Xenopus laevis) | 27250 | -4.165 | -0.0445 | Yes |
| 143 | VEGFC | NA | VEGFC Entrez, Source | vascular endothelial growth factor C | 27284 | -4.454 | -0.0221 | Yes |
| 144 | CDCP1 | NA | CDCP1 Entrez, Source | CUB domain containing protein 1 | 27286 | -4.471 | 0.0016 | Yes |
