Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | CAHOY_ASTROCYTIC |
| Enrichment Score (ES) | 0.4540229 |
| Normalized Enrichment Score (NES) | 1.5684603 |
| Nominal p-value | 0.0019569471 |
| FDR q-value | 0.015332157 |
| FWER p-Value | 0.141 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | APP | NA | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 128 | 3.406 | 0.0264 | Yes |
| 2 | GLT25D2 | NA | GLT25D2 Entrez, Source | glycosyltransferase 25 domain containing 2 | 133 | 3.391 | 0.0573 | Yes |
| 3 | VEGFA | NA | 162 | 3.331 | 0.0867 | Yes | ||
| 4 | NRARP | NA | 181 | 3.296 | 0.1161 | Yes | ||
| 5 | CHRDL1 | NA | CHRDL1 Entrez, Source | chordin-like 1 | 371 | 2.973 | 0.1364 | Yes |
| 6 | TMEM51 | NA | TMEM51 Entrez, Source | transmembrane protein 51 | 440 | 2.881 | 0.1602 | Yes |
| 7 | NMB | NA | NMB Entrez, Source | neuromedin B | 456 | 2.863 | 0.1858 | Yes |
| 8 | SLC1A2 | NA | SLC1A2 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 722 | 2.549 | 0.1994 | Yes |
| 9 | AGPAT4 | NA | AGPAT4 Entrez, Source | 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) | 813 | 2.463 | 0.2186 | Yes |
| 10 | TTYH3 | NA | TTYH3 Entrez, Source | tweety homolog 3 (Drosophila) | 944 | 2.358 | 0.2353 | Yes |
| 11 | HEY2 | NA | HEY2 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 2 | 1019 | 2.306 | 0.2537 | Yes |
| 12 | ABCD2 | NA | ABCD2 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 2 | 1036 | 2.294 | 0.2741 | Yes |
| 13 | PTPLAD1 | NA | PTPLAD1 Entrez, Source | protein tyrosine phosphatase-like A domain containing 1 | 1356 | 2.066 | 0.2812 | Yes |
| 14 | CORO1C | NA | CORO1C Entrez, Source | coronin, actin binding protein, 1C | 1431 | 2.017 | 0.2969 | Yes |
| 15 | KCNJ16 | NA | KCNJ16 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 16 | 1471 | 1.995 | 0.3137 | Yes |
| 16 | BCAT1 | NA | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 1516 | 1.968 | 0.3301 | Yes |
| 17 | TNFRSF19 | NA | TNFRSF19 Entrez, Source | tumor necrosis factor receptor superfamily, member 19 | 1742 | 1.852 | 0.3388 | Yes |
| 18 | SLC25A34 | NA | SLC25A34 Entrez, Source | solute carrier family 25, member 34 | 1780 | 1.834 | 0.3542 | Yes |
| 19 | IL17RD | NA | IL17RD Entrez, Source | interleukin 17 receptor D | 1796 | 1.824 | 0.3703 | Yes |
| 20 | CBS | NA | CBS Entrez, Source | cystathionine-beta-synthase | 1812 | 1.816 | 0.3863 | Yes |
| 21 | FRMD5 | NA | FRMD5 Entrez, Source | FERM domain containing 5 | 2194 | 1.635 | 0.3873 | Yes |
| 22 | AGT | NA | AGT Entrez, Source | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 2542 | 1.486 | 0.3881 | Yes |
| 23 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 2555 | 1.479 | 0.4012 | Yes |
| 24 | ELOVL2 | NA | ELOVL2 Entrez, Source | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 | 2759 | 1.396 | 0.4065 | Yes |
| 25 | BMPR1B | NA | BMPR1B Entrez, Source | bone morphogenetic protein receptor, type IB | 2763 | 1.394 | 0.4191 | Yes |
| 26 | RNF24 | NA | RNF24 Entrez, Source | ring finger protein 24 | 3087 | 1.281 | 0.4190 | Yes |
| 27 | LYRM4 | NA | LYRM4 Entrez, Source | LYR motif containing 4 | 3852 | 1.034 | 0.4004 | Yes |
| 28 | STK38L | NA | STK38L Entrez, Source | serine/threonine kinase 38 like | 3864 | 1.031 | 0.4094 | Yes |
| 29 | NIPAL3 | NA | 3919 | 1.012 | 0.4166 | Yes | ||
| 30 | MFGE8 | NA | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 4030 | 0.978 | 0.4215 | Yes |
| 31 | PHKG1 | NA | PHKG1 Entrez, Source | phosphorylase kinase, gamma 1 (muscle) | 4073 | 0.966 | 0.4288 | Yes |
| 32 | RARRES1 | NA | RARRES1 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 1 | 4092 | 0.961 | 0.4370 | Yes |
| 33 | SLC27A1 | NA | SLC27A1 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 1 | 4160 | 0.942 | 0.4431 | Yes |
| 34 | HAPLN1 | NA | HAPLN1 Entrez, Source | hyaluronan and proteoglycan link protein 1 | 4331 | 0.900 | 0.4451 | Yes |
| 35 | PLA2G3 | NA | PLA2G3 Entrez, Source | phospholipase A2, group III | 4498 | 0.861 | 0.4468 | Yes |
| 36 | SEMA3E | NA | SEMA3E Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 4517 | 0.857 | 0.4540 | Yes |
| 37 | ADCYAP1R1 | NA | ADCYAP1R1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | 4982 | 0.747 | 0.4438 | No |
| 38 | SCG3 | NA | SCG3 Entrez, Source | secretogranin III | 5082 | 0.725 | 0.4468 | No |
| 39 | KCTD14 | NA | KCTD14 Entrez, Source | potassium channel tetramerisation domain containing 14 | 5412 | 0.636 | 0.4405 | No |
| 40 | TECTB | NA | TECTB Entrez, Source | tectorin beta | 6596 | 0.441 | 0.4011 | No |
| 41 | ATP1A1 | NA | ATP1A1 Entrez, Source | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 6929 | 0.404 | 0.3926 | No |
| 42 | THRSP | NA | THRSP Entrez, Source | thyroid hormone responsive (SPOT14 homolog, rat) | 7368 | 0.358 | 0.3798 | No |
| 43 | NTSR2 | NA | NTSR2 Entrez, Source | neurotensin receptor 2 | 7463 | 0.348 | 0.3795 | No |
| 44 | BTBD17 | NA | 7938 | 0.306 | 0.3649 | No | ||
| 45 | AQP9 | NA | AQP9 Entrez, Source | aquaporin 9 | 8240 | 0.282 | 0.3564 | No |
| 46 | FAM20A | NA | FAM20A Entrez, Source | family with sequence similarity 20, member A | 8861 | 0.238 | 0.3358 | No |
| 47 | AIFM3 | NA | 9349 | 0.211 | 0.3199 | No | ||
| 48 | KIAA1161 | NA | KIAA1161 Entrez, Source | KIAA1161 | 9404 | 0.208 | 0.3198 | No |
| 49 | GPAM | NA | GPAM Entrez, Source | glycerol-3-phosphate acyltransferase, mitochondrial | 9470 | 0.205 | 0.3193 | No |
| 50 | MERTK | NA | MERTK Entrez, Source | c-mer proto-oncogene tyrosine kinase | 9550 | 0.201 | 0.3182 | No |
| 51 | RSPO1 | NA | RSPO1 Entrez, Source | R-spondin homolog (Xenopus laevis) | 9562 | 0.200 | 0.3196 | No |
| 52 | SLC7A10 | NA | SLC7A10 Entrez, Source | solute carrier family 7, (neutral amino acid transporter, y+ system) member 10 | 9856 | 0.185 | 0.3106 | No |
| 53 | LGI4 | NA | LGI4 Entrez, Source | leucine-rich repeat LGI family, member 4 | 9861 | 0.185 | 0.3121 | No |
| 54 | BTG1 | NA | BTG1 Entrez, Source | B-cell translocation gene 1, anti-proliferative | 10950 | 0.135 | 0.2734 | No |
| 55 | SLC6A11 | NA | SLC6A11 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, GABA), member 11 | 11087 | 0.128 | 0.2696 | No |
| 56 | FGFR3 | NA | FGFR3 Entrez, Source | fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) | 11229 | 0.122 | 0.2655 | No |
| 57 | ELF5 | NA | ELF5 Entrez, Source | E74-like factor 5 (ets domain transcription factor) | 11300 | 0.118 | 0.2640 | No |
| 58 | CYP4F11 | NA | CYP4F11 Entrez, Source | cytochrome P450, family 4, subfamily F, polypeptide 11 | 12758 | 0.062 | 0.2111 | No |
| 59 | RORB | NA | RORB Entrez, Source | RAR-related orphan receptor B | 13479 | 0.034 | 0.1850 | No |
| 60 | SPIRE1 | NA | SPIRE1 Entrez, Source | spire homolog 1 (Drosophila) | 13661 | 0.028 | 0.1786 | No |
| 61 | GABRG1 | NA | GABRG1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, gamma 1 | 14231 | 0.007 | 0.1577 | No |
| 62 | SLC30A10 | NA | SLC30A10 Entrez, Source | solute carrier family 30, member 10 | 14441 | -0.000 | 0.1501 | No |
| 63 | CKAP5 | NA | CKAP5 Entrez, Source | cytoskeleton associated protein 5 | 14798 | -0.013 | 0.1371 | No |
| 64 | ATP13A4 | NA | ATP13A4 Entrez, Source | ATPase type 13A4 | 15300 | -0.033 | 0.1190 | No |
| 65 | ASNS | NA | ASNS Entrez, Source | asparagine synthetase | 15753 | -0.051 | 0.1029 | No |
| 66 | CYP7B1 | NA | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 16078 | -0.063 | 0.0915 | No |
| 67 | PANK1 | NA | PANK1 Entrez, Source | pantothenate kinase 1 | 16336 | -0.075 | 0.0828 | No |
| 68 | PLD2 | NA | PLD2 Entrez, Source | phospholipase D2 | 16867 | -0.096 | 0.0642 | No |
| 69 | DNAI1 | NA | DNAI1 Entrez, Source | dynein, axonemal, intermediate chain 1 | 16951 | -0.099 | 0.0621 | No |
| 70 | SLC7A11 | NA | SLC7A11 Entrez, Source | solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 | 17180 | -0.109 | 0.0547 | No |
| 71 | SLC13A5 | NA | SLC13A5 Entrez, Source | solute carrier family 13 (sodium-dependent citrate transporter), member 5 | 17724 | -0.136 | 0.0360 | No |
| 72 | DIO2 | NA | DIO2 Entrez, Source | deiodinase, iodothyronine, type II | 17895 | -0.147 | 0.0311 | No |
| 73 | HSD11B1 | NA | HSD11B1 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 1 | 17896 | -0.147 | 0.0324 | No |
| 74 | FARS2 | NA | FARS2 Entrez, Source | phenylalanine-tRNA synthetase 2 (mitochondrial) | 18436 | -0.181 | 0.0143 | No |
| 75 | MYOM3 | NA | MYOM3 Entrez, Source | myomesin family, member 3 | 19002 | -0.227 | -0.0044 | No |
| 76 | HEPH | NA | HEPH Entrez, Source | hephaestin | 19667 | -0.286 | -0.0262 | No |
| 77 | FGD6 | NA | FGD6 Entrez, Source | FYVE, RhoGEF and PH domain containing 6 | 20374 | -0.365 | -0.0487 | No |
| 78 | EGFL6 | NA | EGFL6 Entrez, Source | EGF-like-domain, multiple 6 | 20516 | -0.382 | -0.0504 | No |
| 79 | GPR85 | NA | GPR85 Entrez, Source | G protein-coupled receptor 85 | 21083 | -0.465 | -0.0670 | No |
| 80 | RGS20 | NA | RGS20 Entrez, Source | regulator of G-protein signalling 20 | 21414 | -0.518 | -0.0744 | No |
| 81 | RASA2 | NA | RASA2 Entrez, Source | RAS p21 protein activator 2 | 21520 | -0.538 | -0.0733 | No |
| 82 | GRIN2C | NA | GRIN2C Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2C | 22756 | -0.785 | -0.1115 | No |
| 83 | VNN1 | NA | VNN1 Entrez, Source | vanin 1 | 23043 | -0.847 | -0.1142 | No |
| 84 | PPARA | NA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 23325 | -0.907 | -0.1163 | No |
| 85 | PAK3 | NA | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 23565 | -0.969 | -0.1162 | No |
| 86 | ABHD1 | NA | ABHD1 Entrez, Source | abhydrolase domain containing 1 | 23707 | -1.009 | -0.1122 | No |
| 87 | PPP1R3D | NA | PPP1R3D Entrez, Source | protein phosphatase 1, regulatory subunit 3D | 23912 | -1.068 | -0.1099 | No |
| 88 | LPGAT1 | NA | LPGAT1 Entrez, Source | lysophosphatidylglycerol acyltransferase 1 | 24698 | -1.308 | -0.1268 | No |
| 89 | SLC46A1 | NA | 24932 | -1.390 | -0.1226 | No | ||
| 90 | RAN | NA | RAN Entrez, Source | RAN, member RAS oncogene family | 25032 | -1.431 | -0.1132 | No |
| 91 | IMPA2 | NA | IMPA2 Entrez, Source | inositol(myo)-1(or 4)-monophosphatase 2 | 25251 | -1.521 | -0.1073 | No |
| 92 | SYPL2 | NA | SYPL2 Entrez, Source | synaptophysin-like 2 | 25781 | -1.782 | -0.1104 | No |
| 93 | PAPSS2 | NA | PAPSS2 Entrez, Source | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 25932 | -1.875 | -0.0988 | No |
| 94 | COX10 | NA | COX10 Entrez, Source | COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) | 25950 | -1.884 | -0.0822 | No |
| 95 | GOT2 | NA | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 26072 | -1.961 | -0.0687 | No |
| 96 | TTPA | NA | TTPA Entrez, Source | tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency) | 26149 | -2.022 | -0.0530 | No |
| 97 | ABCB9 | NA | ABCB9 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | 26417 | -2.225 | -0.0425 | No |
| 98 | NCEH1 | NA | 26484 | -2.284 | -0.0241 | No | ||
| 99 | GRHL1 | NA | GRHL1 Entrez, Source | grainyhead-like 1 (Drosophila) | 26667 | -2.461 | -0.0083 | No |
| 100 | ADORA2B | NA | ADORA2B Entrez, Source | adenosine A2b receptor | 27155 | -3.561 | 0.0064 | No |
