Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | CRX_DN.V1_UP |
| Enrichment Score (ES) | -0.30704522 |
| Normalized Enrichment Score (NES) | -1.2713177 |
| Nominal p-value | 0.0862423 |
| FDR q-value | 0.26043895 |
| FWER p-Value | 0.816 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | XIST | NA | XIST Entrez, Source | X (inactive)-specific transcript | 53 | 3.643 | 0.0256 | No |
| 2 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 130 | 3.400 | 0.0486 | No |
| 3 | RPE65 | NA | RPE65 Entrez, Source | retinal pigment epithelium-specific protein 65kDa | 424 | 2.898 | 0.0598 | No |
| 4 | ST8SIA1 | NA | ST8SIA1 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 577 | 2.693 | 0.0746 | No |
| 5 | FAM107B | NA | FAM107B Entrez, Source | family with sequence similarity 107, member B | 632 | 2.640 | 0.0926 | No |
| 6 | MEF2C | NA | MEF2C Entrez, Source | MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) | 648 | 2.622 | 0.1119 | No |
| 7 | SLC25A25 | NA | SLC25A25 Entrez, Source | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | 780 | 2.491 | 0.1259 | No |
| 8 | TAOK3 | NA | TAOK3 Entrez, Source | TAO kinase 3 | 1118 | 2.235 | 0.1304 | No |
| 9 | DPF3 | NA | DPF3 Entrez, Source | D4, zinc and double PHD fingers, family 3 | 1453 | 2.005 | 0.1333 | No |
| 10 | WISP1 | NA | WISP1 Entrez, Source | WNT1 inducible signaling pathway protein 1 | 1568 | 1.941 | 0.1438 | No |
| 11 | RANGRF | NA | 1645 | 1.897 | 0.1554 | No | ||
| 12 | C14orf37 | NA | C14ORF37 Entrez, Source | chromosome 14 open reading frame 37 | 1675 | 1.882 | 0.1686 | No |
| 13 | FAAH | NA | FAAH Entrez, Source | fatty acid amide hydrolase | 1775 | 1.838 | 0.1789 | No |
| 14 | AQP1 | NA | AQP1 Entrez, Source | aquaporin 1 (Colton blood group) | 1811 | 1.816 | 0.1913 | No |
| 15 | PPP3CC | NA | PPP3CC Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) | 1876 | 1.789 | 0.2025 | No |
| 16 | DHH | NA | DHH Entrez, Source | desert hedgehog homolog (Drosophila) | 1941 | 1.757 | 0.2135 | No |
| 17 | PTPN21 | NA | PTPN21 Entrez, Source | protein tyrosine phosphatase, non-receptor type 21 | 2093 | 1.681 | 0.2207 | No |
| 18 | TRAFD1 | NA | TRAFD1 Entrez, Source | TRAF-type zinc finger domain containing 1 | 2139 | 1.661 | 0.2316 | No |
| 19 | RGR | NA | RGR Entrez, Source | retinal G protein coupled receptor | 2537 | 1.487 | 0.2282 | No |
| 20 | UBTD1 | NA | UBTD1 Entrez, Source | ubiquitin domain containing 1 | 2716 | 1.417 | 0.2324 | No |
| 21 | NRM | NA | NRM Entrez, Source | nurim (nuclear envelope membrane protein) | 3096 | 1.278 | 0.2282 | No |
| 22 | GAS7 | NA | GAS7 Entrez, Source | growth arrest-specific 7 | 3520 | 1.148 | 0.2213 | No |
| 23 | WDR31 | NA | WDR31 Entrez, Source | WD repeat domain 31 | 3700 | 1.083 | 0.2229 | No |
| 24 | PAQR4 | NA | PAQR4 Entrez, Source | progestin and adipoQ receptor family member IV | 3816 | 1.045 | 0.2266 | No |
| 25 | MMP23B | NA | MMP23B Entrez, Source | matrix metallopeptidase 23B | 4110 | 0.955 | 0.2231 | No |
| 26 | GPSM2 | NA | GPSM2 Entrez, Source | G-protein signalling modulator 2 (AGS3-like, C. elegans) | 4209 | 0.929 | 0.2265 | No |
| 27 | SELENBP1 | NA | SELENBP1 Entrez, Source | selenium binding protein 1 | 4235 | 0.924 | 0.2326 | No |
| 28 | CKMT1A | NA | CKMT1A Entrez, Source | creatine kinase, mitochondrial 1A | 4265 | 0.917 | 0.2384 | No |
| 29 | TMEM229B | NA | 4649 | 0.826 | 0.2306 | No | ||
| 30 | TMEM218 | NA | 5104 | 0.719 | 0.2194 | No | ||
| 31 | ALPL | NA | ALPL Entrez, Source | alkaline phosphatase, liver/bone/kidney | 5400 | 0.638 | 0.2133 | No |
| 32 | PACRG | NA | PACRG Entrez, Source | PARK2 co-regulated | 5552 | 0.606 | 0.2124 | No |
| 33 | PLEKHF2 | NA | PLEKHF2 Entrez, Source | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 5646 | 0.588 | 0.2134 | No |
| 34 | CSGALNACT2 | NA | 6159 | 0.503 | 0.1984 | No | ||
| 35 | TMEM27 | NA | TMEM27 Entrez, Source | transmembrane protein 27 | 6166 | 0.503 | 0.2020 | No |
| 36 | TMEM35 | NA | TMEM35 Entrez, Source | transmembrane protein 35 | 6168 | 0.502 | 0.2057 | No |
| 37 | CCDC107 | NA | CCDC107 Entrez, Source | coiled-coil domain containing 107 | 6189 | 0.499 | 0.2088 | No |
| 38 | PPAP2C | NA | PPAP2C Entrez, Source | phosphatidic acid phosphatase type 2C | 6641 | 0.436 | 0.1955 | No |
| 39 | WDR78 | NA | WDR78 Entrez, Source | WD repeat domain 78 | 6652 | 0.435 | 0.1984 | No |
| 40 | ALPK2 | NA | ALPK2 Entrez, Source | alpha-kinase 2 | 6935 | 0.404 | 0.1911 | No |
| 41 | DDHD1 | NA | DDHD1 Entrez, Source | DDHD domain containing 1 | 7083 | 0.389 | 0.1887 | No |
| 42 | BMP15 | NA | BMP15 Entrez, Source | bone morphogenetic protein 15 | 8682 | 0.250 | 0.1318 | No |
| 43 | TCP11 | NA | TCP11 Entrez, Source | t-complex 11 (mouse) | 9233 | 0.217 | 0.1132 | No |
| 44 | GNAT1 | NA | GNAT1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 | 9243 | 0.217 | 0.1145 | No |
| 45 | OPN1SW | NA | OPN1SW Entrez, Source | opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) | 10267 | 0.166 | 0.0782 | No |
| 46 | ESRRB | NA | ESRRB Entrez, Source | estrogen-related receptor beta | 10871 | 0.138 | 0.0570 | No |
| 47 | SLC24A1 | NA | SLC24A1 Entrez, Source | solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 | 11215 | 0.122 | 0.0453 | No |
| 48 | RS1 | NA | RS1 Entrez, Source | retinoschisis (X-linked, juvenile) 1 | 11397 | 0.113 | 0.0395 | No |
| 49 | STK17B | NA | STK17B Entrez, Source | serine/threonine kinase 17b (apoptosis-inducing) | 11936 | 0.093 | 0.0205 | No |
| 50 | ZFP57 | NA | ZFP57 Entrez, Source | zinc finger protein 57 homolog (mouse) | 12212 | 0.082 | 0.0110 | No |
| 51 | RHPN1 | NA | RHPN1 Entrez, Source | rhophilin, Rho GTPase binding protein 1 | 12472 | 0.072 | 0.0020 | No |
| 52 | RCVRN | NA | RCVRN Entrez, Source | recoverin | 12590 | 0.068 | -0.0018 | No |
| 53 | AGR2 | NA | AGR2 Entrez, Source | anterior gradient 2 homolog (Xenopus laevis) | 12667 | 0.065 | -0.0041 | No |
| 54 | DOCK8 | NA | DOCK8 Entrez, Source | dedicator of cytokinesis 8 | 13027 | 0.052 | -0.0169 | No |
| 55 | KCNE2 | NA | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 13287 | 0.042 | -0.0261 | No |
| 56 | STRA6 | NA | STRA6 Entrez, Source | stimulated by retinoic acid gene 6 homolog (mouse) | 13602 | 0.029 | -0.0374 | No |
| 57 | KLKB1 | NA | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 13759 | 0.024 | -0.0430 | No |
| 58 | ANKRD33 | NA | ANKRD33 Entrez, Source | ankyrin repeat domain 33 | 14221 | 0.007 | -0.0599 | No |
| 59 | GRK1 | NA | GRK1 Entrez, Source | G protein-coupled receptor kinase 1 | 14380 | 0.002 | -0.0657 | No |
| 60 | CABP4 | NA | CABP4 Entrez, Source | calcium binding protein 4 | 14752 | -0.011 | -0.0793 | No |
| 61 | INSL5 | NA | INSL5 Entrez, Source | insulin-like 5 | 14754 | -0.011 | -0.0792 | No |
| 62 | GPSM3 | NA | GPSM3 Entrez, Source | G-protein signalling modulator 3 (AGS3-like, C. elegans) | 15135 | -0.027 | -0.0930 | No |
| 63 | RPGRIP1 | NA | RPGRIP1 Entrez, Source | retinitis pigmentosa GTPase regulator interacting protein 1 | 15448 | -0.038 | -0.1042 | No |
| 64 | VTN | NA | VTN Entrez, Source | vitronectin | 15462 | -0.039 | -0.1043 | No |
| 65 | GCKR | NA | GCKR Entrez, Source | glucokinase (hexokinase 4) regulator | 15562 | -0.043 | -0.1077 | No |
| 66 | SERINC4 | NA | SERINC4 Entrez, Source | serine incorporator 4 | 15757 | -0.051 | -0.1144 | No |
| 67 | FAM161A | NA | 16020 | -0.061 | -0.1236 | No | ||
| 68 | PLA2R1 | NA | PLA2R1 Entrez, Source | phospholipase A2 receptor 1, 180kDa | 16358 | -0.076 | -0.1354 | No |
| 69 | PDE6H | NA | PDE6H Entrez, Source | phosphodiesterase 6H, cGMP-specific, cone, gamma | 16537 | -0.082 | -0.1413 | No |
| 70 | SH2D1A | NA | SH2D1A Entrez, Source | SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) | 16694 | -0.089 | -0.1464 | No |
| 71 | SLC17A1 | NA | SLC17A1 Entrez, Source | solute carrier family 17 (sodium phosphate), member 1 | 16813 | -0.094 | -0.1500 | No |
| 72 | OSGEP | NA | OSGEP Entrez, Source | O-sialoglycoprotein endopeptidase | 17080 | -0.105 | -0.1590 | No |
| 73 | CCDC64 | NA | CCDC64 Entrez, Source | coiled-coil domain containing 64 | 17110 | -0.106 | -0.1593 | No |
| 74 | MDM1 | NA | MDM1 Entrez, Source | Mdm4, transformed 3T3 cell double minute 1, p53 binding protein (mouse) | 17230 | -0.112 | -0.1628 | No |
| 75 | SYNPO2 | NA | SYNPO2 Entrez, Source | synaptopodin 2 | 17274 | -0.113 | -0.1635 | No |
| 76 | NXNL1 | NA | 17327 | -0.116 | -0.1645 | No | ||
| 77 | ZDHHC12 | NA | ZDHHC12 Entrez, Source | zinc finger, DHHC-type containing 12 | 17555 | -0.127 | -0.1719 | No |
| 78 | CLDN7 | NA | CLDN7 Entrez, Source | claudin 7 | 18028 | -0.155 | -0.1881 | No |
| 79 | RABGEF1 | NA | RABGEF1 Entrez, Source | RAB guanine nucleotide exchange factor (GEF) 1 | 18206 | -0.166 | -0.1934 | No |
| 80 | STK35 | NA | STK35 Entrez, Source | serine/threonine kinase 35 | 18257 | -0.169 | -0.1939 | No |
| 81 | HCLS1 | NA | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 18598 | -0.193 | -0.2050 | No |
| 82 | CDR2 | NA | CDR2 Entrez, Source | cerebellar degeneration-related protein 2, 62kDa | 18628 | -0.196 | -0.2046 | No |
| 83 | GZMM | NA | GZMM Entrez, Source | granzyme M (lymphocyte met-ase 1) | 18821 | -0.212 | -0.2100 | No |
| 84 | SUV39H2 | NA | SUV39H2 Entrez, Source | suppressor of variegation 3-9 homolog 2 (Drosophila) | 18931 | -0.221 | -0.2124 | No |
| 85 | RTBDN | NA | RTBDN Entrez, Source | retbindin | 19481 | -0.268 | -0.2305 | No |
| 86 | SGCG | NA | SGCG Entrez, Source | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 19775 | -0.297 | -0.2390 | No |
| 87 | ABCA4 | NA | ABCA4 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 4 | 19843 | -0.304 | -0.2392 | No |
| 88 | PRPH2 | NA | 20459 | -0.375 | -0.2590 | No | ||
| 89 | DOHH | NA | DOHH Entrez, Source | deoxyhypusine hydroxylase/monooxygenase | 20484 | -0.378 | -0.2570 | No |
| 90 | B4GALT1 | NA | B4GALT1 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 20527 | -0.383 | -0.2556 | No |
| 91 | COL19A1 | NA | COL19A1 Entrez, Source | collagen, type XIX, alpha 1 | 20601 | -0.393 | -0.2553 | No |
| 92 | TMLHE | NA | TMLHE Entrez, Source | trimethyllysine hydroxylase, epsilon | 20958 | -0.447 | -0.2651 | No |
| 93 | MC1R | NA | MC1R Entrez, Source | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 21346 | -0.506 | -0.2755 | No |
| 94 | DUSP14 | NA | DUSP14 Entrez, Source | dual specificity phosphatase 14 | 21366 | -0.509 | -0.2723 | No |
| 95 | ARG2 | NA | ARG2 Entrez, Source | arginase, type II | 21927 | -0.613 | -0.2882 | No |
| 96 | RDH12 | NA | RDH12 Entrez, Source | retinol dehydrogenase 12 (all-trans/9-cis/11-cis) | 22119 | -0.650 | -0.2903 | No |
| 97 | RDH5 | NA | RDH5 Entrez, Source | retinol dehydrogenase 5 (11-cis/9-cis) | 22170 | -0.660 | -0.2872 | No |
| 98 | GUCA1B | NA | GUCA1B Entrez, Source | guanylate cyclase activator 1B (retina) | 22300 | -0.688 | -0.2867 | No |
| 99 | SH3YL1 | NA | SH3YL1 Entrez, Source | SH3 domain containing, Ysc84-like 1 (S. cerevisiae) | 22404 | -0.708 | -0.2851 | No |
| 100 | GRTP1 | NA | GRTP1 Entrez, Source | growth hormone regulated TBC protein 1 | 22683 | -0.770 | -0.2895 | No |
| 101 | ONECUT1 | NA | ONECUT1 Entrez, Source | one cut domain, family member 1 | 23160 | -0.870 | -0.3005 | Yes |
| 102 | KCNJ14 | NA | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 23202 | -0.880 | -0.2953 | Yes |
| 103 | TNFAIP3 | NA | TNFAIP3 Entrez, Source | tumor necrosis factor, alpha-induced protein 3 | 23231 | -0.887 | -0.2896 | Yes |
| 104 | OPN1MW | NA | OPN1MW Entrez, Source | opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) | 23430 | -0.933 | -0.2898 | Yes |
| 105 | PFKFB2 | NA | PFKFB2 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 23623 | -0.987 | -0.2894 | Yes |
| 106 | RNF123 | NA | RNF123 Entrez, Source | ring finger protein 123 | 24026 | -1.095 | -0.2959 | Yes |
| 107 | PDE6A | NA | PDE6A Entrez, Source | phosphodiesterase 6A, cGMP-specific, rod, alpha | 24050 | -1.104 | -0.2884 | Yes |
| 108 | LOC253039 | NA | LOC253039 Entrez, Source | - | 24059 | -1.105 | -0.2803 | Yes |
| 109 | BST1 | NA | BST1 Entrez, Source | bone marrow stromal cell antigen 1 | 24154 | -1.136 | -0.2752 | Yes |
| 110 | NXNL2 | NA | 24600 | -1.276 | -0.2819 | Yes | ||
| 111 | SNTB2 | NA | SNTB2 Entrez, Source | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | 24643 | -1.291 | -0.2736 | Yes |
| 112 | TTC39C | NA | 24663 | -1.297 | -0.2645 | Yes | ||
| 113 | NAT1 | NA | NAT1 Entrez, Source | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 24686 | -1.304 | -0.2555 | Yes |
| 114 | BUB1B | NA | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 24763 | -1.334 | -0.2482 | Yes |
| 115 | UBXN11 | NA | 24868 | -1.368 | -0.2416 | Yes | ||
| 116 | SNTA1 | NA | SNTA1 Entrez, Source | syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) | 24914 | -1.385 | -0.2328 | Yes |
| 117 | PDIA5 | NA | PDIA5 Entrez, Source | protein disulfide isomerase family A, member 5 | 25079 | -1.452 | -0.2278 | Yes |
| 118 | FAIM | NA | FAIM Entrez, Source | Fas apoptotic inhibitory molecule | 25124 | -1.473 | -0.2183 | Yes |
| 119 | C16orf74 | NA | C16ORF74 Entrez, Source | chromosome 16 open reading frame 74 | 25160 | -1.487 | -0.2083 | Yes |
| 120 | C11orf9 | NA | C11ORF9 Entrez, Source | chromosome 11 open reading frame 9 | 25322 | -1.558 | -0.2024 | Yes |
| 121 | BATF2 | NA | BATF2 Entrez, Source | basic leucine zipper transcription factor, ATF-like 2 | 25360 | -1.576 | -0.1919 | Yes |
| 122 | ARHGAP10 | NA | ARHGAP10 Entrez, Source | Rho GTPase activating protein 10 | 25435 | -1.610 | -0.1824 | Yes |
| 123 | POLG2 | NA | POLG2 Entrez, Source | polymerase (DNA directed), gamma 2, accessory subunit | 25575 | -1.677 | -0.1748 | Yes |
| 124 | SNTG2 | NA | SNTG2 Entrez, Source | syntrophin, gamma 2 | 25788 | -1.785 | -0.1691 | Yes |
| 125 | SP6 | NA | SP6 Entrez, Source | Sp6 transcription factor | 25876 | -1.844 | -0.1583 | Yes |
| 126 | REEP6 | NA | REEP6 Entrez, Source | receptor accessory protein 6 | 25886 | -1.850 | -0.1447 | Yes |
| 127 | RNF207 | NA | RNF207 Entrez, Source | ring finger protein 207 | 26043 | -1.945 | -0.1357 | Yes |
| 128 | HSPA1B | NA | HSPA1B Entrez, Source | heat shock 70kDa protein 1B | 26174 | -2.044 | -0.1250 | Yes |
| 129 | MYLK | NA | MYLK Entrez, Source | myosin, light chain kinase | 26239 | -2.081 | -0.1116 | Yes |
| 130 | RAD51 | NA | RAD51 Entrez, Source | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 26348 | -2.170 | -0.0991 | Yes |
| 131 | KRT18 | NA | KRT18 Entrez, Source | keratin 18 | 27009 | -3.061 | -0.1002 | Yes |
| 132 | BCAR3 | NA | BCAR3 Entrez, Source | breast cancer anti-estrogen resistance 3 | 27039 | -3.153 | -0.0774 | Yes |
| 133 | IER3 | NA | IER3 Entrez, Source | immediate early response 3 | 27068 | -3.228 | -0.0540 | Yes |
| 134 | LLGL2 | NA | LLGL2 Entrez, Source | lethal giant larvae homolog 2 (Drosophila) | 27234 | -4.038 | -0.0295 | Yes |
| 135 | HSPA1A | NA | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 27277 | -4.348 | 0.0019 | Yes |
