Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | CRX_NRL_DN.V1_UP |
| Enrichment Score (ES) | -0.32596114 |
| Normalized Enrichment Score (NES) | -1.1980691 |
| Nominal p-value | 0.18930042 |
| FDR q-value | 0.22644886 |
| FWER p-Value | 0.918 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | XIST | NA | XIST Entrez, Source | X (inactive)-specific transcript | 53 | 3.643 | 0.0219 | No |
| 2 | CDKN2C | NA | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 93 | 3.507 | 0.0434 | No |
| 3 | FXYD6 | NA | FXYD6 Entrez, Source | FXYD domain containing ion transport regulator 6 | 104 | 3.468 | 0.0658 | No |
| 4 | ST8SIA1 | NA | ST8SIA1 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 577 | 2.693 | 0.0661 | No |
| 5 | MEF2C | NA | MEF2C Entrez, Source | MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) | 648 | 2.622 | 0.0807 | No |
| 6 | SLC25A25 | NA | SLC25A25 Entrez, Source | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | 780 | 2.491 | 0.0922 | No |
| 7 | GADD45A | NA | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 793 | 2.479 | 0.1080 | No |
| 8 | MEST | NA | MEST Entrez, Source | mesoderm specific transcript homolog (mouse) | 913 | 2.379 | 0.1192 | No |
| 9 | RFX2 | NA | RFX2 Entrez, Source | regulatory factor X, 2 (influences HLA class II expression) | 1061 | 2.271 | 0.1286 | No |
| 10 | TAOK3 | NA | TAOK3 Entrez, Source | TAO kinase 3 | 1118 | 2.235 | 0.1412 | No |
| 11 | CAMK1D | NA | CAMK1D Entrez, Source | calcium/calmodulin-dependent protein kinase ID | 1282 | 2.112 | 0.1491 | No |
| 12 | ST3GAL1 | NA | ST3GAL1 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 1368 | 2.060 | 0.1594 | No |
| 13 | BCL2L11 | NA | BCL2L11 Entrez, Source | BCL2-like 11 (apoptosis facilitator) | 1377 | 2.056 | 0.1726 | No |
| 14 | DPF3 | NA | DPF3 Entrez, Source | D4, zinc and double PHD fingers, family 3 | 1453 | 2.005 | 0.1830 | No |
| 15 | WISP1 | NA | WISP1 Entrez, Source | WNT1 inducible signaling pathway protein 1 | 1568 | 1.941 | 0.1915 | No |
| 16 | SAP30 | NA | SAP30 Entrez, Source | Sin3A-associated protein, 30kDa | 1726 | 1.859 | 0.1979 | No |
| 17 | AQP1 | NA | AQP1 Entrez, Source | aquaporin 1 (Colton blood group) | 1811 | 1.816 | 0.2067 | No |
| 18 | TENC1 | NA | TENC1 Entrez, Source | tensin like C1 domain containing phosphatase (tensin 2) | 1836 | 1.807 | 0.2177 | No |
| 19 | AHRR | NA | AHRR Entrez, Source | aryl-hydrocarbon receptor repressor | 1840 | 1.806 | 0.2294 | No |
| 20 | BBS9 | NA | 1887 | 1.784 | 0.2394 | No | ||
| 21 | DHH | NA | DHH Entrez, Source | desert hedgehog homolog (Drosophila) | 1941 | 1.757 | 0.2489 | No |
| 22 | PLEKHA2 | NA | PLEKHA2 Entrez, Source | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 2233 | 1.622 | 0.2488 | No |
| 23 | CRYBB1 | NA | CRYBB1 Entrez, Source | crystallin, beta B1 | 2997 | 1.311 | 0.2294 | No |
| 24 | NRM | NA | NRM Entrez, Source | nurim (nuclear envelope membrane protein) | 3096 | 1.278 | 0.2341 | No |
| 25 | MLL3 | NA | MLL3 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia 3 | 3311 | 1.210 | 0.2342 | No |
| 26 | GAS7 | NA | GAS7 Entrez, Source | growth arrest-specific 7 | 3520 | 1.148 | 0.2341 | No |
| 27 | PAQR4 | NA | PAQR4 Entrez, Source | progestin and adipoQ receptor family member IV | 3816 | 1.045 | 0.2300 | No |
| 28 | MOGAT1 | NA | MOGAT1 Entrez, Source | monoacylglycerol O-acyltransferase 1 | 3991 | 0.989 | 0.2301 | No |
| 29 | PRKAB1 | NA | PRKAB1 Entrez, Source | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 4049 | 0.973 | 0.2344 | No |
| 30 | GPSM2 | NA | GPSM2 Entrez, Source | G-protein signalling modulator 2 (AGS3-like, C. elegans) | 4209 | 0.929 | 0.2346 | No |
| 31 | CKMT1A | NA | CKMT1A Entrez, Source | creatine kinase, mitochondrial 1A | 4265 | 0.917 | 0.2386 | No |
| 32 | DRD4 | NA | DRD4 Entrez, Source | dopamine receptor D4 | 4343 | 0.897 | 0.2417 | No |
| 33 | ZFP36L2 | NA | ZFP36L2 Entrez, Source | zinc finger protein 36, C3H type-like 2 | 5144 | 0.709 | 0.2169 | No |
| 34 | ABHD14A | NA | ABHD14A Entrez, Source | abhydrolase domain containing 14A | 5283 | 0.666 | 0.2162 | No |
| 35 | EDN2 | NA | EDN2 Entrez, Source | endothelin 2 | 5342 | 0.651 | 0.2183 | No |
| 36 | ALPL | NA | ALPL Entrez, Source | alkaline phosphatase, liver/bone/kidney | 5400 | 0.638 | 0.2204 | No |
| 37 | NRL | NA | NRL Entrez, Source | neural retina leucine zipper | 5810 | 0.559 | 0.2090 | No |
| 38 | SEC14L2 | NA | SEC14L2 Entrez, Source | SEC14-like 2 (S. cerevisiae) | 5882 | 0.550 | 0.2100 | No |
| 39 | CCDC107 | NA | CCDC107 Entrez, Source | coiled-coil domain containing 107 | 6189 | 0.499 | 0.2020 | No |
| 40 | ARL4D | NA | ARL4D Entrez, Source | ADP-ribosylation factor-like 4D | 6300 | 0.481 | 0.2011 | No |
| 41 | REC8 | NA | 6497 | 0.453 | 0.1969 | No | ||
| 42 | PPAP2C | NA | PPAP2C Entrez, Source | phosphatidic acid phosphatase type 2C | 6641 | 0.436 | 0.1945 | No |
| 43 | SLC5A5 | NA | SLC5A5 Entrez, Source | solute carrier family 5 (sodium iodide symporter), member 5 | 7972 | 0.303 | 0.1476 | No |
| 44 | SSBP4 | NA | SSBP4 Entrez, Source | single stranded DNA binding protein 4 | 8564 | 0.259 | 0.1275 | No |
| 45 | TCP11 | NA | TCP11 Entrez, Source | t-complex 11 (mouse) | 9233 | 0.217 | 0.1044 | No |
| 46 | GNAT1 | NA | GNAT1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 | 9243 | 0.217 | 0.1055 | No |
| 47 | PCOLCE | NA | PCOLCE Entrez, Source | procollagen C-endopeptidase enhancer | 10193 | 0.170 | 0.0717 | No |
| 48 | EPS8L1 | NA | EPS8L1 Entrez, Source | EPS8-like 1 | 10551 | 0.153 | 0.0595 | No |
| 49 | TNNT2 | NA | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 10748 | 0.144 | 0.0533 | No |
| 50 | ESRRB | NA | ESRRB Entrez, Source | estrogen-related receptor beta | 10871 | 0.138 | 0.0497 | No |
| 51 | SLC24A1 | NA | SLC24A1 Entrez, Source | solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 | 11215 | 0.122 | 0.0379 | No |
| 52 | ZC3H3 | NA | ZC3H3 Entrez, Source | zinc finger CCCH-type containing 3 | 11255 | 0.120 | 0.0372 | No |
| 53 | RS1 | NA | RS1 Entrez, Source | retinoschisis (X-linked, juvenile) 1 | 11397 | 0.113 | 0.0328 | No |
| 54 | RHO | NA | RHO Entrez, Source | rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant) | 11718 | 0.101 | 0.0217 | No |
| 55 | GALNT10 | NA | GALNT10 Entrez, Source | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) | 11732 | 0.100 | 0.0219 | No |
| 56 | STK17B | NA | STK17B Entrez, Source | serine/threonine kinase 17b (apoptosis-inducing) | 11936 | 0.093 | 0.0150 | No |
| 57 | C10orf99 | NA | C10ORF99 Entrez, Source | chromosome 10 open reading frame 99 | 12203 | 0.082 | 0.0058 | No |
| 58 | RHPN1 | NA | RHPN1 Entrez, Source | rhophilin, Rho GTPase binding protein 1 | 12472 | 0.072 | -0.0036 | No |
| 59 | ACVR2B | NA | ACVR2B Entrez, Source | activin A receptor, type IIB | 13139 | 0.047 | -0.0278 | No |
| 60 | KCNE2 | NA | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 13287 | 0.042 | -0.0329 | No |
| 61 | PSD | NA | PSD Entrez, Source | pleckstrin and Sec7 domain containing | 13406 | 0.037 | -0.0370 | No |
| 62 | KCNB1 | NA | KCNB1 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 1 | 14340 | 0.003 | -0.0713 | No |
| 63 | WWTR1 | NA | WWTR1 Entrez, Source | WW domain containing transcription regulator 1 | 14476 | -0.002 | -0.0763 | No |
| 64 | CABP4 | NA | CABP4 Entrez, Source | calcium binding protein 4 | 14752 | -0.011 | -0.0863 | No |
| 65 | NR2E3 | NA | NR2E3 Entrez, Source | nuclear receptor subfamily 2, group E, member 3 | 14893 | -0.017 | -0.0914 | No |
| 66 | TFF3 | NA | TFF3 Entrez, Source | trefoil factor 3 (intestinal) | 15504 | -0.041 | -0.1135 | No |
| 67 | ATP8A2 | NA | ATP8A2 Entrez, Source | ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2 | 15641 | -0.046 | -0.1182 | No |
| 68 | SERINC4 | NA | SERINC4 Entrez, Source | serine incorporator 4 | 15757 | -0.051 | -0.1221 | No |
| 69 | CRYGB | NA | CRYGB Entrez, Source | crystallin, gamma B | 15760 | -0.051 | -0.1219 | No |
| 70 | PLA2R1 | NA | PLA2R1 Entrez, Source | phospholipase A2 receptor 1, 180kDa | 16358 | -0.076 | -0.1433 | No |
| 71 | SH2D1A | NA | SH2D1A Entrez, Source | SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) | 16694 | -0.089 | -0.1551 | No |
| 72 | CCDC64 | NA | CCDC64 Entrez, Source | coiled-coil domain containing 64 | 17110 | -0.106 | -0.1696 | No |
| 73 | IMPG1 | NA | IMPG1 Entrez, Source | interphotoreceptor matrix proteoglycan 1 | 17119 | -0.107 | -0.1692 | No |
| 74 | NXNL1 | NA | 17327 | -0.116 | -0.1761 | No | ||
| 75 | ZDHHC12 | NA | ZDHHC12 Entrez, Source | zinc finger, DHHC-type containing 12 | 17555 | -0.127 | -0.1836 | No |
| 76 | GFAP | NA | GFAP Entrez, Source | glial fibrillary acidic protein | 17858 | -0.145 | -0.1937 | No |
| 77 | SAMD11 | NA | SAMD11 Entrez, Source | sterile alpha motif domain containing 11 | 17888 | -0.147 | -0.1939 | No |
| 78 | BEST2 | NA | 18490 | -0.185 | -0.2147 | No | ||
| 79 | HCLS1 | NA | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 18598 | -0.193 | -0.2174 | No |
| 80 | CDR2 | NA | CDR2 Entrez, Source | cerebellar degeneration-related protein 2, 62kDa | 18628 | -0.196 | -0.2172 | No |
| 81 | RTBDN | NA | RTBDN Entrez, Source | retbindin | 19481 | -0.268 | -0.2468 | No |
| 82 | DIAPH3 | NA | DIAPH3 Entrez, Source | diaphanous homolog 3 (Drosophila) | 19978 | -0.318 | -0.2629 | No |
| 83 | CNGA1 | NA | CNGA1 Entrez, Source | cyclic nucleotide gated channel alpha 1 | 20048 | -0.326 | -0.2633 | No |
| 84 | DOHH | NA | DOHH Entrez, Source | deoxyhypusine hydroxylase/monooxygenase | 20484 | -0.378 | -0.2769 | No |
| 85 | B4GALT1 | NA | B4GALT1 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 20527 | -0.383 | -0.2759 | No |
| 86 | COL19A1 | NA | COL19A1 Entrez, Source | collagen, type XIX, alpha 1 | 20601 | -0.393 | -0.2760 | No |
| 87 | TNIP2 | NA | TNIP2 Entrez, Source | TNFAIP3 interacting protein 2 | 21105 | -0.469 | -0.2914 | No |
| 88 | MC1R | NA | MC1R Entrez, Source | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 21346 | -0.506 | -0.2969 | No |
| 89 | ARG2 | NA | ARG2 Entrez, Source | arginase, type II | 21927 | -0.613 | -0.3143 | No |
| 90 | RDH12 | NA | RDH12 Entrez, Source | retinol dehydrogenase 12 (all-trans/9-cis/11-cis) | 22119 | -0.650 | -0.3170 | No |
| 91 | GUCA1B | NA | GUCA1B Entrez, Source | guanylate cyclase activator 1B (retina) | 22300 | -0.688 | -0.3191 | No |
| 92 | CROCC | NA | CROCC Entrez, Source | ciliary rootlet coiled-coil, rootletin | 22320 | -0.691 | -0.3153 | No |
| 93 | DHRS3 | NA | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 22386 | -0.704 | -0.3131 | No |
| 94 | SYTL1 | NA | SYTL1 Entrez, Source | synaptotagmin-like 1 | 22529 | -0.736 | -0.3135 | No |
| 95 | GRTP1 | NA | GRTP1 Entrez, Source | growth hormone regulated TBC protein 1 | 22683 | -0.770 | -0.3141 | No |
| 96 | KCNN4 | NA | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 23007 | -0.840 | -0.3205 | Yes |
| 97 | ANKRD33B | NA | 23050 | -0.848 | -0.3164 | Yes | ||
| 98 | KCNJ14 | NA | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 23202 | -0.880 | -0.3162 | Yes |
| 99 | TNFAIP3 | NA | TNFAIP3 Entrez, Source | tumor necrosis factor, alpha-induced protein 3 | 23231 | -0.887 | -0.3115 | Yes |
| 100 | PPARA | NA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 23325 | -0.907 | -0.3089 | Yes |
| 101 | OPN1MW | NA | OPN1MW Entrez, Source | opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) | 23430 | -0.933 | -0.3066 | Yes |
| 102 | ABCG4 | NA | ABCG4 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 4 | 23526 | -0.958 | -0.3039 | Yes |
| 103 | MYO7A | NA | MYO7A Entrez, Source | myosin VIIA | 23735 | -1.016 | -0.3049 | Yes |
| 104 | MLF1 | NA | MLF1 Entrez, Source | myeloid leukemia factor 1 | 23877 | -1.059 | -0.3031 | Yes |
| 105 | RNF123 | NA | RNF123 Entrez, Source | ring finger protein 123 | 24026 | -1.095 | -0.3014 | Yes |
| 106 | PDE6A | NA | PDE6A Entrez, Source | phosphodiesterase 6A, cGMP-specific, rod, alpha | 24050 | -1.104 | -0.2950 | Yes |
| 107 | LOC253039 | NA | LOC253039 Entrez, Source | - | 24059 | -1.105 | -0.2880 | Yes |
| 108 | BST1 | NA | BST1 Entrez, Source | bone marrow stromal cell antigen 1 | 24154 | -1.136 | -0.2841 | Yes |
| 109 | LRRC2 | NA | LRRC2 Entrez, Source | leucine rich repeat containing 2 | 24238 | -1.161 | -0.2795 | Yes |
| 110 | NXNL2 | NA | 24600 | -1.276 | -0.2844 | Yes | ||
| 111 | SNTB2 | NA | SNTB2 Entrez, Source | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | 24643 | -1.291 | -0.2775 | Yes |
| 112 | SLC16A6 | NA | SLC16A6 Entrez, Source | solute carrier family 16, member 6 (monocarboxylic acid transporter 7) | 24660 | -1.296 | -0.2696 | Yes |
| 113 | TTC39C | NA | 24663 | -1.297 | -0.2612 | Yes | ||
| 114 | BUB1B | NA | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 24763 | -1.334 | -0.2561 | Yes |
| 115 | UBXN11 | NA | 24868 | -1.368 | -0.2510 | Yes | ||
| 116 | SNTA1 | NA | SNTA1 Entrez, Source | syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) | 24914 | -1.385 | -0.2436 | Yes |
| 117 | C10orf47 | NA | C10ORF47 Entrez, Source | chromosome 10 open reading frame 47 | 25034 | -1.432 | -0.2385 | Yes |
| 118 | PDIA5 | NA | PDIA5 Entrez, Source | protein disulfide isomerase family A, member 5 | 25079 | -1.452 | -0.2307 | Yes |
| 119 | FAIM | NA | FAIM Entrez, Source | Fas apoptotic inhibitory molecule | 25124 | -1.473 | -0.2226 | Yes |
| 120 | ARHGAP10 | NA | ARHGAP10 Entrez, Source | Rho GTPase activating protein 10 | 25435 | -1.610 | -0.2235 | Yes |
| 121 | KLHL36 | NA | 25442 | -1.612 | -0.2131 | Yes | ||
| 122 | POLG2 | NA | POLG2 Entrez, Source | polymerase (DNA directed), gamma 2, accessory subunit | 25575 | -1.677 | -0.2070 | Yes |
| 123 | ARMC1 | NA | ARMC1 Entrez, Source | armadillo repeat containing 1 | 25670 | -1.721 | -0.1992 | Yes |
| 124 | PDE8A | NA | PDE8A Entrez, Source | phosphodiesterase 8A | 25774 | -1.778 | -0.1913 | Yes |
| 125 | SNTG2 | NA | SNTG2 Entrez, Source | syntrophin, gamma 2 | 25788 | -1.785 | -0.1801 | Yes |
| 126 | REEP6 | NA | REEP6 Entrez, Source | receptor accessory protein 6 | 25886 | -1.850 | -0.1716 | Yes |
| 127 | RNF207 | NA | RNF207 Entrez, Source | ring finger protein 207 | 26043 | -1.945 | -0.1646 | Yes |
| 128 | HSPA1B | NA | HSPA1B Entrez, Source | heat shock 70kDa protein 1B | 26174 | -2.044 | -0.1560 | Yes |
| 129 | SLC16A3 | NA | SLC16A3 Entrez, Source | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) | 26293 | -2.125 | -0.1464 | Yes |
| 130 | PTPN18 | NA | PTPN18 Entrez, Source | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 26569 | -2.355 | -0.1411 | Yes |
| 131 | PIP4K2C | NA | 26585 | -2.372 | -0.1261 | Yes | ||
| 132 | PPARGC1B | NA | PPARGC1B Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, beta | 26621 | -2.408 | -0.1116 | Yes |
| 133 | SLC29A2 | NA | SLC29A2 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 2 | 26988 | -3.010 | -0.1053 | Yes |
| 134 | TNNT1 | NA | TNNT1 Entrez, Source | troponin T type 1 (skeletal, slow) | 27044 | -3.163 | -0.0867 | Yes |
| 135 | EXT1 | NA | EXT1 Entrez, Source | exostoses (multiple) 1 | 27055 | -3.195 | -0.0661 | Yes |
| 136 | IER3 | NA | IER3 Entrez, Source | immediate early response 3 | 27068 | -3.228 | -0.0454 | Yes |
| 137 | LLGL2 | NA | LLGL2 Entrez, Source | lethal giant larvae homolog 2 (Drosophila) | 27234 | -4.038 | -0.0250 | Yes |
| 138 | HSPA1A | NA | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 27277 | -4.348 | 0.0019 | Yes |
