Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | KRAS.AMP.LUNG_UP.V1_UP |
| Enrichment Score (ES) | 0.3753316 |
| Normalized Enrichment Score (NES) | 1.5990342 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.009951914 |
| FWER p-Value | 0.099 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | NOVA1 | NA | NOVA1 Entrez, Source | neuro-oncological ventral antigen 1 | 269 | 3.137 | 0.0256 | Yes |
| 2 | NPAS3 | NA | NPAS3 Entrez, Source | neuronal PAS domain protein 3 | 283 | 3.111 | 0.0603 | Yes |
| 3 | MAN1C1 | NA | MAN1C1 Entrez, Source | mannosidase, alpha, class 1C, member 1 | 423 | 2.900 | 0.0880 | Yes |
| 4 | KCNC1 | NA | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 698 | 2.579 | 0.1072 | Yes |
| 5 | HSPA6 | NA | HSPA6 Entrez, Source | heat shock 70kDa protein 6 (HSP70B') | 699 | 2.578 | 0.1363 | Yes |
| 6 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 718 | 2.553 | 0.1646 | Yes |
| 7 | ST3GAL6 | NA | ST3GAL6 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 923 | 2.370 | 0.1839 | Yes |
| 8 | LPL | NA | LPL Entrez, Source | lipoprotein lipase | 1059 | 2.272 | 0.2046 | Yes |
| 9 | EGF | NA | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 1262 | 2.127 | 0.2213 | Yes |
| 10 | ABCC6 | NA | ABCC6 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | 1400 | 2.036 | 0.2393 | Yes |
| 11 | SPP1 | NA | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 1647 | 1.897 | 0.2517 | Yes |
| 12 | MMP15 | NA | MMP15 Entrez, Source | matrix metallopeptidase 15 (membrane-inserted) | 1663 | 1.892 | 0.2725 | Yes |
| 13 | SLC26A4 | NA | SLC26A4 Entrez, Source | solute carrier family 26, member 4 | 1834 | 1.807 | 0.2867 | Yes |
| 14 | MCF2L | NA | MCF2L Entrez, Source | MCF.2 cell line derived transforming sequence-like | 2225 | 1.624 | 0.2908 | Yes |
| 15 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 2555 | 1.479 | 0.2954 | Yes |
| 16 | FKBP6 | NA | FKBP6 Entrez, Source | FK506 binding protein 6, 36kDa | 2621 | 1.452 | 0.3095 | Yes |
| 17 | NDOR1 | NA | NDOR1 Entrez, Source | NADPH dependent diflavin oxidoreductase 1 | 2809 | 1.383 | 0.3183 | Yes |
| 18 | FAM174B | NA | 2825 | 1.377 | 0.3333 | Yes | ||
| 19 | TUBA8 | NA | TUBA8 Entrez, Source | tubulin, alpha 8 | 2965 | 1.320 | 0.3431 | Yes |
| 20 | HIST1H2BB | NA | HIST1H2BB Entrez, Source | histone cluster 1, H2bb | 3458 | 1.166 | 0.3382 | Yes |
| 21 | DYNC1I1 | NA | DYNC1I1 Entrez, Source | dynein, cytoplasmic 1, intermediate chain 1 | 3602 | 1.115 | 0.3456 | Yes |
| 22 | ZNF257 | NA | ZNF257 Entrez, Source | zinc finger protein 257 | 3633 | 1.105 | 0.3570 | Yes |
| 23 | HGFAC | NA | HGFAC Entrez, Source | HGF activator | 3777 | 1.059 | 0.3637 | Yes |
| 24 | ZNF835 | NA | 3787 | 1.055 | 0.3753 | Yes | ||
| 25 | FGF7 | NA | FGF7 Entrez, Source | fibroblast growth factor 7 (keratinocyte growth factor) | 4120 | 0.953 | 0.3739 | No |
| 26 | SEMA3E | NA | SEMA3E Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 4517 | 0.857 | 0.3690 | No |
| 27 | TTLL3 | NA | TTLL3 Entrez, Source | tubulin tyrosine ligase-like family, member 3 | 5259 | 0.674 | 0.3494 | No |
| 28 | CRYBA1 | NA | CRYBA1 Entrez, Source | crystallin, beta A1 | 5336 | 0.652 | 0.3540 | No |
| 29 | MYOZ1 | NA | MYOZ1 Entrez, Source | myozenin 1 | 5917 | 0.543 | 0.3388 | No |
| 30 | REST | NA | REST Entrez, Source | RE1-silencing transcription factor | 5934 | 0.540 | 0.3444 | No |
| 31 | TMEM35 | NA | TMEM35 Entrez, Source | transmembrane protein 35 | 6168 | 0.502 | 0.3415 | No |
| 32 | CLEC4A | NA | CLEC4A Entrez, Source | C-type lectin domain family 4, member A | 6642 | 0.436 | 0.3290 | No |
| 33 | GNGT2 | NA | GNGT2 Entrez, Source | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 | 6711 | 0.427 | 0.3313 | No |
| 34 | HSF1 | NA | HSF1 Entrez, Source | heat shock transcription factor 1 | 6725 | 0.426 | 0.3357 | No |
| 35 | EFNA2 | NA | EFNA2 Entrez, Source | ephrin-A2 | 6728 | 0.425 | 0.3404 | No |
| 36 | GPR6 | NA | GPR6 Entrez, Source | G protein-coupled receptor 6 | 6969 | 0.400 | 0.3361 | No |
| 37 | CA5A | NA | CA5A Entrez, Source | carbonic anhydrase VA, mitochondrial | 7138 | 0.382 | 0.3343 | No |
| 38 | C8orf39 | NA | C8ORF39 Entrez, Source | chromosome 8 open reading frame 39 | 7401 | 0.354 | 0.3287 | No |
| 39 | C22orf43 | NA | 7434 | 0.351 | 0.3315 | No | ||
| 40 | GABRR1 | NA | GABRR1 Entrez, Source | gamma-aminobutyric acid (GABA) receptor, rho 1 | 7489 | 0.345 | 0.3334 | No |
| 41 | NGF | NA | 7575 | 0.338 | 0.3341 | No | ||
| 42 | EFCAB6 | NA | 7923 | 0.307 | 0.3248 | No | ||
| 43 | DUSP9 | NA | DUSP9 Entrez, Source | dual specificity phosphatase 9 | 8076 | 0.294 | 0.3225 | No |
| 44 | HIST1H2BN | NA | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 8523 | 0.262 | 0.3091 | No |
| 45 | CELA2B | NA | 8879 | 0.237 | 0.2987 | No | ||
| 46 | ASIP | NA | ASIP Entrez, Source | agouti signaling protein, nonagouti homolog (mouse) | 9122 | 0.223 | 0.2923 | No |
| 47 | PAX4 | NA | PAX4 Entrez, Source | paired box gene 4 | 9836 | 0.186 | 0.2682 | No |
| 48 | BMPER | NA | BMPER Entrez, Source | BMP binding endothelial regulator | 9849 | 0.186 | 0.2699 | No |
| 49 | ATXN3L | NA | ATXN3L Entrez, Source | ataxin 3-like | 10031 | 0.177 | 0.2652 | No |
| 50 | GABRR2 | NA | GABRR2 Entrez, Source | gamma-aminobutyric acid (GABA) receptor, rho 2 | 10178 | 0.171 | 0.2618 | No |
| 51 | OPN1SW | NA | OPN1SW Entrez, Source | opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) | 10267 | 0.166 | 0.2605 | No |
| 52 | TNNT2 | NA | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 10748 | 0.144 | 0.2444 | No |
| 53 | ST8SIA2 | NA | ST8SIA2 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 10967 | 0.134 | 0.2379 | No |
| 54 | SSTR1 | NA | SSTR1 Entrez, Source | somatostatin receptor 1 | 11073 | 0.129 | 0.2355 | No |
| 55 | GIP | NA | GIP Entrez, Source | gastric inhibitory polypeptide | 11138 | 0.126 | 0.2346 | No |
| 56 | IL26 | NA | IL26 Entrez, Source | interleukin 26 | 11157 | 0.125 | 0.2354 | No |
| 57 | HCN4 | NA | HCN4 Entrez, Source | hyperpolarization activated cyclic nucleotide-gated potassium channel 4 | 11285 | 0.118 | 0.2320 | No |
| 58 | GATA1 | NA | GATA1 Entrez, Source | GATA binding protein 1 (globin transcription factor 1) | 11309 | 0.117 | 0.2325 | No |
| 59 | F13A1 | NA | F13A1 Entrez, Source | coagulation factor XIII, A1 polypeptide | 11523 | 0.110 | 0.2259 | No |
| 60 | HSD3B2 | NA | HSD3B2 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | 11646 | 0.104 | 0.2226 | No |
| 61 | SPTA1 | NA | SPTA1 Entrez, Source | spectrin, alpha, erythrocytic 1 (elliptocytosis 2) | 11788 | 0.098 | 0.2185 | No |
| 62 | DLX5 | NA | DLX5 Entrez, Source | distal-less homeobox 5 | 12050 | 0.088 | 0.2099 | No |
| 63 | NMUR1 | NA | NMUR1 Entrez, Source | neuromedin U receptor 1 | 12127 | 0.086 | 0.2081 | No |
| 64 | DOCK3 | NA | DOCK3 Entrez, Source | dedicator of cytokinesis 3 | 12347 | 0.077 | 0.2009 | No |
| 65 | PRKG2 | NA | PRKG2 Entrez, Source | protein kinase, cGMP-dependent, type II | 12361 | 0.076 | 0.2013 | No |
| 66 | CCT8L2 | NA | 12412 | 0.074 | 0.2003 | No | ||
| 67 | CD247 | NA | CD247 Entrez, Source | CD247 molecule | 12530 | 0.070 | 0.1968 | No |
| 68 | TDRD1 | NA | TDRD1 Entrez, Source | tudor domain containing 1 | 12543 | 0.070 | 0.1972 | No |
| 69 | NPBWR2 | NA | NPBWR2 Entrez, Source | neuropeptides B/W receptor 2 | 12581 | 0.068 | 0.1966 | No |
| 70 | MAGEB1 | NA | MAGEB1 Entrez, Source | melanoma antigen family B, 1 | 13200 | 0.045 | 0.1744 | No |
| 71 | NPHS1 | NA | NPHS1 Entrez, Source | nephrosis 1, congenital, Finnish type (nephrin) | 13321 | 0.040 | 0.1704 | No |
| 72 | CLSTN2 | NA | CLSTN2 Entrez, Source | calsyntenin 2 | 13398 | 0.037 | 0.1680 | No |
| 73 | XPNPEP2 | NA | XPNPEP2 Entrez, Source | X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound | 13674 | 0.027 | 0.1582 | No |
| 74 | C11orf16 | NA | C11ORF16 Entrez, Source | chromosome 11 open reading frame 16 | 13975 | 0.016 | 0.1474 | No |
| 75 | OPRK1 | NA | OPRK1 Entrez, Source | opioid receptor, kappa 1 | 14020 | 0.014 | 0.1459 | No |
| 76 | GPR44 | NA | GPR44 Entrez, Source | G protein-coupled receptor 44 | 14024 | 0.014 | 0.1460 | No |
| 77 | FCER1G | NA | FCER1G Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 14128 | 0.011 | 0.1423 | No |
| 78 | LY75 | NA | LY75 Entrez, Source | lymphocyte antigen 75 | 14245 | 0.006 | 0.1381 | No |
| 79 | VENTX | NA | VENTX Entrez, Source | VENT homeobox homolog (Xenopus laevis) | 14344 | 0.003 | 0.1345 | No |
| 80 | SLC6A6 | NA | SLC6A6 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | 14876 | -0.016 | 0.1152 | No |
| 81 | PIWIL1 | NA | PIWIL1 Entrez, Source | piwi-like 1 (Drosophila) | 14979 | -0.020 | 0.1117 | No |
| 82 | PNMA3 | NA | PNMA3 Entrez, Source | paraneoplastic antigen MA3 | 15190 | -0.029 | 0.1043 | No |
| 83 | CYP3A7 | NA | CYP3A7 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 7 | 15308 | -0.033 | 0.1003 | No |
| 84 | CLEC5A | NA | CLEC5A Entrez, Source | C-type lectin domain family 5, member A | 15453 | -0.039 | 0.0955 | No |
| 85 | VTN | NA | VTN Entrez, Source | vitronectin | 15462 | -0.039 | 0.0956 | No |
| 86 | FCRL2 | NA | FCRL2 Entrez, Source | Fc receptor-like 2 | 15522 | -0.042 | 0.0939 | No |
| 87 | GCKR | NA | GCKR Entrez, Source | glucokinase (hexokinase 4) regulator | 15562 | -0.043 | 0.0930 | No |
| 88 | HECW1 | NA | HECW1 Entrez, Source | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | 15661 | -0.047 | 0.0899 | No |
| 89 | SLC25A31 | NA | SLC25A31 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 | 15810 | -0.052 | 0.0851 | No |
| 90 | GRP | NA | GRP Entrez, Source | gastrin-releasing peptide | 15949 | -0.057 | 0.0806 | No |
| 91 | AFP | NA | AFP Entrez, Source | alpha-fetoprotein | 15994 | -0.060 | 0.0797 | No |
| 92 | GPR25 | NA | GPR25 Entrez, Source | G protein-coupled receptor 25 | 16232 | -0.071 | 0.0718 | No |
| 93 | CAMK1G | NA | CAMK1G Entrez, Source | calcium/calmodulin-dependent protein kinase IG | 16393 | -0.077 | 0.0668 | No |
| 94 | GABRA6 | NA | GABRA6 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 6 | 16571 | -0.084 | 0.0612 | No |
| 95 | ALLC | NA | ALLC Entrez, Source | allantoicase | 16670 | -0.088 | 0.0586 | No |
| 96 | CEBPE | NA | CEBPE Entrez, Source | CCAAT/enhancer binding protein (C/EBP), epsilon | 17079 | -0.105 | 0.0448 | No |
| 97 | RAB30 | NA | RAB30 Entrez, Source | RAB30, member RAS oncogene family | 17240 | -0.112 | 0.0402 | No |
| 98 | SOX12 | NA | SOX12 Entrez, Source | SRY (sex determining region Y)-box 12 | 17247 | -0.112 | 0.0412 | No |
| 99 | BTG4 | NA | BTG4 Entrez, Source | B-cell translocation gene 4 | 17352 | -0.117 | 0.0387 | No |
| 100 | CD3E | NA | CD3E Entrez, Source | CD3e molecule, epsilon (CD3-TCR complex) | 17403 | -0.120 | 0.0382 | No |
| 101 | SPINK1 | NA | SPINK1 Entrez, Source | serine peptidase inhibitor, Kazal type 1 | 18001 | -0.153 | 0.0180 | No |
| 102 | DEFA5 | NA | DEFA5 Entrez, Source | defensin, alpha 5, Paneth cell-specific | 18021 | -0.154 | 0.0191 | No |
| 103 | C10orf81 | NA | C10ORF81 Entrez, Source | chromosome 10 open reading frame 81 | 18304 | -0.172 | 0.0106 | No |
| 104 | ABCG5 | NA | ABCG5 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) | 18420 | -0.180 | 0.0084 | No |
| 105 | SLAMF1 | NA | SLAMF1 Entrez, Source | signaling lymphocytic activation molecule family member 1 | 18553 | -0.189 | 0.0057 | No |
| 106 | LENEP | NA | LENEP Entrez, Source | lens epithelial protein | 18750 | -0.206 | 0.0009 | No |
| 107 | FCER1A | NA | FCER1A Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 18996 | -0.227 | -0.0056 | No |
| 108 | PAGE4 | NA | PAGE4 Entrez, Source | P antigen family, member 4 (prostate associated) | 19238 | -0.247 | -0.0117 | No |
| 109 | CFHR5 | NA | CFHR5 Entrez, Source | complement factor H-related 5 | 19295 | -0.251 | -0.0109 | No |
| 110 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 19296 | -0.251 | -0.0080 | No |
| 111 | CSN2 | NA | CSN2 Entrez, Source | casein beta | 19482 | -0.268 | -0.0118 | No |
| 112 | KLK14 | NA | KLK14 Entrez, Source | kallikrein 14 | 19590 | -0.279 | -0.0126 | No |
| 113 | SLC7A9 | NA | SLC7A9 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 | 20132 | -0.335 | -0.0287 | No |
| 114 | RCAN2 | NA | 20320 | -0.358 | -0.0315 | No | ||
| 115 | CCDC57 | NA | CCDC57 Entrez, Source | coiled-coil domain containing 57 | 20364 | -0.364 | -0.0290 | No |
| 116 | GPR68 | NA | GPR68 Entrez, Source | G protein-coupled receptor 68 | 20646 | -0.398 | -0.0348 | No |
| 117 | ATG10 | NA | ATG10 Entrez, Source | ATG10 autophagy related 10 homolog (S. cerevisiae) | 20685 | -0.404 | -0.0316 | No |
| 118 | EFNA3 | NA | EFNA3 Entrez, Source | ephrin-A3 | 20716 | -0.409 | -0.0281 | No |
| 119 | HPR | NA | HPR Entrez, Source | haptoglobin-related protein | 20926 | -0.441 | -0.0308 | No |
| 120 | CLSTN3 | NA | CLSTN3 Entrez, Source | calsyntenin 3 | 20943 | -0.444 | -0.0264 | No |
| 121 | OTOR | NA | OTOR Entrez, Source | otoraplin | 21148 | -0.474 | -0.0285 | No |
| 122 | OSBP2 | NA | OSBP2 Entrez, Source | oxysterol binding protein 2 | 21630 | -0.556 | -0.0399 | No |
| 123 | RPL23AP53 | NA | 21648 | -0.560 | -0.0342 | No | ||
| 124 | CCL11 | NA | CCL11 Entrez, Source | chemokine (C-C motif) ligand 11 | 21975 | -0.625 | -0.0391 | No |
| 125 | NPHP1 | NA | NPHP1 Entrez, Source | nephronophthisis 1 (juvenile) | 21983 | -0.626 | -0.0323 | No |
| 126 | SLC2A4 | NA | SLC2A4 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 4 | 22083 | -0.645 | -0.0286 | No |
| 127 | NELL2 | NA | NELL2 Entrez, Source | NEL-like 2 (chicken) | 22466 | -0.721 | -0.0345 | No |
| 128 | SDCCAG8 | NA | SDCCAG8 Entrez, Source | serologically defined colon cancer antigen 8 | 22608 | -0.756 | -0.0311 | No |
| 129 | JAK3 | NA | JAK3 Entrez, Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 23405 | -0.927 | -0.0499 | No |
| 130 | B3GNTL1 | NA | B3GNTL1 Entrez, Source | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | 25465 | -1.623 | -0.1072 | No |
| 131 | HSPA1L | NA | HSPA1L Entrez, Source | heat shock 70kDa protein 1-like | 25695 | -1.738 | -0.0960 | No |
| 132 | C8orf59 | NA | C8ORF59 Entrez, Source | chromosome 8 open reading frame 59 | 26272 | -2.107 | -0.0933 | No |
| 133 | MAGEA12 | NA | MAGEA12 Entrez, Source | melanoma antigen family A, 12 | 26850 | -2.751 | -0.0834 | No |
| 134 | FAM155B | NA | 27228 | -3.985 | -0.0522 | No | ||
| 135 | MAGEA6 | NA | MAGEA6 Entrez, Source | melanoma antigen family A, 6 | 27329 | -4.936 | -0.0000 | No |
