Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | KRAS.KIDNEY_UP.V1_UP |
| Enrichment Score (ES) | 0.6418417 |
| Normalized Enrichment Score (NES) | 1.6539533 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.008231907 |
| FWER p-Value | 0.055 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HEY1 | NA | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 2 | 4.185 | 0.0213 | Yes |
| 2 | PNMA2 | NA | PNMA2 Entrez, Source | paraneoplastic antigen MA2 | 36 | 3.757 | 0.0393 | Yes |
| 3 | SPARCL1 | NA | SPARCL1 Entrez, Source | SPARC-like 1 (mast9, hevin) | 40 | 3.718 | 0.0582 | Yes |
| 4 | NRN1 | NA | NRN1 Entrez, Source | neuritin 1 | 57 | 3.630 | 0.0762 | Yes |
| 5 | PELI2 | NA | PELI2 Entrez, Source | pellino homolog 2 (Drosophila) | 109 | 3.454 | 0.0920 | Yes |
| 6 | SORL1 | NA | SORL1 Entrez, Source | sortilin-related receptor, L(DLR class) A repeats-containing | 119 | 3.420 | 0.1092 | Yes |
| 7 | RAPGEF4 | NA | RAPGEF4 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 4 | 125 | 3.409 | 0.1264 | Yes |
| 8 | GPM6A | NA | GPM6A Entrez, Source | glycoprotein M6A | 168 | 3.322 | 0.1419 | Yes |
| 9 | GPRC5B | NA | GPRC5B Entrez, Source | G protein-coupled receptor, family C, group 5, member B | 188 | 3.287 | 0.1580 | Yes |
| 10 | PLCB1 | NA | PLCB1 Entrez, Source | phospholipase C, beta 1 (phosphoinositide-specific) | 193 | 3.282 | 0.1746 | Yes |
| 11 | CRYAB | NA | CRYAB Entrez, Source | crystallin, alpha B | 203 | 3.264 | 0.1910 | Yes |
| 12 | TRIM9 | NA | TRIM9 Entrez, Source | tripartite motif-containing 9 | 251 | 3.172 | 0.2055 | Yes |
| 13 | DUSP6 | NA | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 312 | 3.058 | 0.2189 | Yes |
| 14 | PLP1 | NA | PLP1 Entrez, Source | proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated) | 339 | 3.012 | 0.2334 | Yes |
| 15 | WSCD1 | NA | 385 | 2.950 | 0.2468 | Yes | ||
| 16 | ANK3 | NA | ANK3 Entrez, Source | ankyrin 3, node of Ranvier (ankyrin G) | 399 | 2.930 | 0.2613 | Yes |
| 17 | METTL7A | NA | METTL7A Entrez, Source | methyltransferase like 7A | 433 | 2.889 | 0.2749 | Yes |
| 18 | SATB1 | NA | SATB1 Entrez, Source | special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) | 451 | 2.868 | 0.2889 | Yes |
| 19 | SEPP1 | NA | SEPP1 Entrez, Source | selenoprotein P, plasma, 1 | 479 | 2.830 | 0.3024 | Yes |
| 20 | TRIL | NA | 514 | 2.775 | 0.3153 | Yes | ||
| 21 | SNAP25 | NA | SNAP25 Entrez, Source | synaptosomal-associated protein, 25kDa | 546 | 2.722 | 0.3281 | Yes |
| 22 | ATP1A2 | NA | ATP1A2 Entrez, Source | ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide | 579 | 2.691 | 0.3407 | Yes |
| 23 | TRIB2 | NA | TRIB2 Entrez, Source | tribbles homolog 2 (Drosophila) | 607 | 2.668 | 0.3533 | Yes |
| 24 | ETV1 | NA | ETV1 Entrez, Source | ets variant gene 1 | 615 | 2.660 | 0.3667 | Yes |
| 25 | FZD3 | NA | FZD3 Entrez, Source | frizzled homolog 3 (Drosophila) | 637 | 2.636 | 0.3794 | Yes |
| 26 | MEF2C | NA | MEF2C Entrez, Source | MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) | 648 | 2.622 | 0.3924 | Yes |
| 27 | SOBP | NA | 657 | 2.617 | 0.4055 | Yes | ||
| 28 | EMP1 | NA | EMP1 Entrez, Source | epithelial membrane protein 1 | 672 | 2.597 | 0.4183 | Yes |
| 29 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 785 | 2.489 | 0.4269 | Yes |
| 30 | TMEM100 | NA | TMEM100 Entrez, Source | transmembrane protein 100 | 797 | 2.471 | 0.4391 | Yes |
| 31 | PEG3 | NA | PEG3 Entrez, Source | paternally expressed 3 | 886 | 2.400 | 0.4482 | Yes |
| 32 | ST3GAL6 | NA | ST3GAL6 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 923 | 2.370 | 0.4590 | Yes |
| 33 | ADCY1 | NA | ADCY1 Entrez, Source | adenylate cyclase 1 (brain) | 945 | 2.356 | 0.4703 | Yes |
| 34 | PMP2 | NA | PMP2 Entrez, Source | peripheral myelin protein 2 | 959 | 2.346 | 0.4818 | Yes |
| 35 | CDK5R1 | NA | CDK5R1 Entrez, Source | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 965 | 2.340 | 0.4936 | Yes |
| 36 | GPR19 | NA | GPR19 Entrez, Source | G protein-coupled receptor 19 | 1003 | 2.316 | 0.5041 | Yes |
| 37 | PCDH9 | NA | PCDH9 Entrez, Source | protocadherin 9 | 1008 | 2.312 | 0.5157 | Yes |
| 38 | NME5 | NA | NME5 Entrez, Source | non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) | 1066 | 2.268 | 0.5252 | Yes |
| 39 | RTN1 | NA | RTN1 Entrez, Source | reticulon 1 | 1084 | 2.254 | 0.5361 | Yes |
| 40 | KIF5C | NA | KIF5C Entrez, Source | kinesin family member 5C | 1092 | 2.248 | 0.5474 | Yes |
| 41 | KCNJ8 | NA | KCNJ8 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 8 | 1270 | 2.122 | 0.5517 | Yes |
| 42 | GABRB1 | NA | GABRB1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, beta 1 | 1274 | 2.119 | 0.5624 | Yes |
| 43 | TMOD1 | NA | TMOD1 Entrez, Source | tropomodulin 1 | 1335 | 2.081 | 0.5709 | Yes |
| 44 | KIT | NA | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 1489 | 1.985 | 0.5754 | Yes |
| 45 | GRIA2 | NA | GRIA2 Entrez, Source | glutamate receptor, ionotropic, AMPA 2 | 1575 | 1.936 | 0.5822 | Yes |
| 46 | SLC1A3 | NA | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 1607 | 1.921 | 0.5909 | Yes |
| 47 | TSPAN7 | NA | TSPAN7 Entrez, Source | tetraspanin 7 | 1625 | 1.909 | 0.6000 | Yes |
| 48 | GATM | NA | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 1673 | 1.883 | 0.6079 | Yes |
| 49 | CA2 | NA | CA2 Entrez, Source | carbonic anhydrase II | 1735 | 1.854 | 0.6152 | Yes |
| 50 | SCN1B | NA | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 2152 | 1.654 | 0.6083 | Yes |
| 51 | NRCAM | NA | NRCAM Entrez, Source | neuronal cell adhesion molecule | 2208 | 1.630 | 0.6146 | Yes |
| 52 | ANK2 | NA | ANK2 Entrez, Source | ankyrin 2, neuronal | 2346 | 1.577 | 0.6177 | Yes |
| 53 | DNM3 | NA | DNM3 Entrez, Source | dynamin 3 | 2393 | 1.551 | 0.6239 | Yes |
| 54 | COPG2 | NA | COPG2 Entrez, Source | coatomer protein complex, subunit gamma 2 | 2511 | 1.500 | 0.6273 | Yes |
| 55 | GAP43 | NA | GAP43 Entrez, Source | growth associated protein 43 | 2743 | 1.403 | 0.6259 | Yes |
| 56 | LIMCH1 | NA | 2847 | 1.368 | 0.6292 | Yes | ||
| 57 | CPE | NA | CPE Entrez, Source | carboxypeptidase E | 3091 | 1.279 | 0.6268 | Yes |
| 58 | GLDC | NA | GLDC Entrez, Source | glycine dehydrogenase (decarboxylating) | 3266 | 1.223 | 0.6266 | Yes |
| 59 | SORBS1 | NA | SORBS1 Entrez, Source | sorbin and SH3 domain containing 1 | 3428 | 1.174 | 0.6267 | Yes |
| 60 | CAB39L | NA | CAB39L Entrez, Source | calcium binding protein 39-like | 3469 | 1.163 | 0.6312 | Yes |
| 61 | GAD1 | NA | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 3483 | 1.159 | 0.6366 | Yes |
| 62 | DYNC1I1 | NA | DYNC1I1 Entrez, Source | dynein, cytoplasmic 1, intermediate chain 1 | 3602 | 1.115 | 0.6380 | Yes |
| 63 | SLC6A1 | NA | SLC6A1 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, GABA), member 1 | 3765 | 1.064 | 0.6375 | Yes |
| 64 | TRIM2 | NA | TRIM2 Entrez, Source | tripartite motif-containing 2 | 3879 | 1.024 | 0.6386 | Yes |
| 65 | NMNAT2 | NA | NMNAT2 Entrez, Source | nicotinamide nucleotide adenylyltransferase 2 | 3931 | 1.008 | 0.6418 | Yes |
| 66 | XK | NA | XK Entrez, Source | X-linked Kx blood group (McLeod syndrome) | 4199 | 0.932 | 0.6368 | No |
| 67 | DDX6 | NA | DDX6 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 | 4551 | 0.850 | 0.6282 | No |
| 68 | PCP4 | NA | PCP4 Entrez, Source | Purkinje cell protein 4 | 4601 | 0.842 | 0.6307 | No |
| 69 | ASPA | NA | ASPA Entrez, Source | aspartoacylase (Canavan disease) | 4621 | 0.836 | 0.6343 | No |
| 70 | SERPINI1 | NA | SERPINI1 Entrez, Source | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 4947 | 0.755 | 0.6262 | No |
| 71 | SCN2A | NA | 5072 | 0.728 | 0.6254 | No | ||
| 72 | SCG3 | NA | SCG3 Entrez, Source | secretogranin III | 5082 | 0.725 | 0.6288 | No |
| 73 | MAFB | NA | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 5115 | 0.716 | 0.6312 | No |
| 74 | AQP4 | NA | AQP4 Entrez, Source | aquaporin 4 | 5173 | 0.702 | 0.6327 | No |
| 75 | AK5 | NA | AK5 Entrez, Source | adenylate kinase 5 | 5289 | 0.665 | 0.6319 | No |
| 76 | MAGEH1 | NA | MAGEH1 Entrez, Source | melanoma antigen family H, 1 | 5851 | 0.553 | 0.6141 | No |
| 77 | PLCL1 | NA | PLCL1 Entrez, Source | phospholipase C-like 1 | 5908 | 0.545 | 0.6148 | No |
| 78 | NOL4 | NA | NOL4 Entrez, Source | nucleolar protein 4 | 5940 | 0.539 | 0.6164 | No |
| 79 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 6145 | 0.506 | 0.6115 | No |
| 80 | GABRA5 | NA | GABRA5 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 5 | 6170 | 0.502 | 0.6132 | No |
| 81 | HPCAL4 | NA | HPCAL4 Entrez, Source | hippocalcin like 4 | 6404 | 0.465 | 0.6070 | No |
| 82 | CDR1 | NA | CDR1 Entrez, Source | cerebellar degeneration-related protein 1, 34kDa | 6804 | 0.418 | 0.5945 | No |
| 83 | D4S234E | NA | D4S234E Entrez, Source | - | 6856 | 0.412 | 0.5947 | No |
| 84 | CHGB | NA | CHGB Entrez, Source | chromogranin B (secretogranin 1) | 6891 | 0.409 | 0.5956 | No |
| 85 | ESRRG | NA | ESRRG Entrez, Source | estrogen-related receptor gamma | 7333 | 0.362 | 0.5812 | No |
| 86 | TCEAL2 | NA | TCEAL2 Entrez, Source | transcription elongation factor A (SII)-like 2 | 8803 | 0.241 | 0.5284 | No |
| 87 | PLSCR4 | NA | PLSCR4 Entrez, Source | phospholipid scramblase 4 | 8863 | 0.238 | 0.5275 | No |
| 88 | GHRH | NA | GHRH Entrez, Source | growth hormone releasing hormone | 8998 | 0.230 | 0.5237 | No |
| 89 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 10099 | 0.174 | 0.4841 | No |
| 90 | GABRR2 | NA | GABRR2 Entrez, Source | gamma-aminobutyric acid (GABA) receptor, rho 2 | 10178 | 0.171 | 0.4821 | No |
| 91 | NRXN1 | NA | NRXN1 Entrez, Source | neurexin 1 | 10464 | 0.158 | 0.4725 | No |
| 92 | EPB41L3 | NA | EPB41L3 Entrez, Source | erythrocyte membrane protein band 4.1-like 3 | 10988 | 0.133 | 0.4539 | No |
| 93 | ZNF536 | NA | ZNF536 Entrez, Source | zinc finger protein 536 | 11634 | 0.105 | 0.4307 | No |
| 94 | FAM153B | NA | 11695 | 0.102 | 0.4290 | No | ||
| 95 | MMP27 | NA | MMP27 Entrez, Source | matrix metallopeptidase 27 | 11873 | 0.095 | 0.4230 | No |
| 96 | NEFL | NA | NEFL Entrez, Source | neurofilament, light polypeptide 68kDa | 12419 | 0.074 | 0.4033 | No |
| 97 | CP | NA | CP Entrez, Source | ceruloplasmin (ferroxidase) | 13305 | 0.041 | 0.3710 | No |
| 98 | HMP19 | NA | HMP19 Entrez, Source | - | 13576 | 0.030 | 0.3612 | No |
| 99 | SLC12A3 | NA | SLC12A3 Entrez, Source | solute carrier family 12 (sodium/chloride transporters), member 3 | 13704 | 0.026 | 0.3567 | No |
| 100 | WIF1 | NA | WIF1 Entrez, Source | WNT inhibitory factor 1 | 14060 | 0.013 | 0.3437 | No |
| 101 | GABRA1 | NA | GABRA1 Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 14115 | 0.011 | 0.3418 | No |
| 102 | RELN | NA | RELN Entrez, Source | reelin | 14279 | 0.005 | 0.3358 | No |
| 103 | GRM5 | NA | GRM5 Entrez, Source | glutamate receptor, metabotropic 5 | 14452 | -0.001 | 0.3295 | No |
| 104 | SMR3A | NA | SMR3A Entrez, Source | submaxillary gland androgen regulated protein 3 homolog A (mouse) | 15322 | -0.034 | 0.2977 | No |
| 105 | CRTAM | NA | CRTAM Entrez, Source | cytotoxic and regulatory T cell molecule | 15421 | -0.038 | 0.2943 | No |
| 106 | GRIK2 | NA | GRIK2 Entrez, Source | glutamate receptor, ionotropic, kainate 2 | 15758 | -0.051 | 0.2822 | No |
| 107 | RIT2 | NA | RIT2 Entrez, Source | Ras-like without CAAX 2 | 15832 | -0.053 | 0.2798 | No |
| 108 | LMO3 | NA | LMO3 Entrez, Source | LIM domain only 3 (rhombotin-like 2) | 16466 | -0.080 | 0.2569 | No |
| 109 | C7orf63 | NA | 16691 | -0.089 | 0.2491 | No | ||
| 110 | SFRP1 | NA | SFRP1 Entrez, Source | secreted frizzled-related protein 1 | 17084 | -0.105 | 0.2352 | No |
| 111 | SV2B | NA | SV2B Entrez, Source | synaptic vesicle glycoprotein 2B | 17293 | -0.115 | 0.2282 | No |
| 112 | CALB1 | NA | CALB1 Entrez, Source | calbindin 1, 28kDa | 17578 | -0.128 | 0.2184 | No |
| 113 | DLGAP2 | NA | DLGAP2 Entrez, Source | discs, large (Drosophila) homolog-associated protein 2 | 17732 | -0.136 | 0.2134 | No |
| 114 | VIPR2 | NA | VIPR2 Entrez, Source | vasoactive intestinal peptide receptor 2 | 18050 | -0.156 | 0.2026 | No |
| 115 | ALDH1A1 | NA | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 18103 | -0.158 | 0.2015 | No |
| 116 | SIGLEC15 | NA | 18395 | -0.178 | 0.1917 | No | ||
| 117 | FGF9 | NA | FGF9 Entrez, Source | fibroblast growth factor 9 (glia-activating factor) | 18634 | -0.196 | 0.1839 | No |
| 118 | NDN | NA | NDN Entrez, Source | necdin homolog (mouse) | 18838 | -0.212 | 0.1776 | No |
| 119 | SLC12A5 | NA | SLC12A5 Entrez, Source | solute carrier family 12, (potassium-chloride transporter) member 5 | 19071 | -0.233 | 0.1702 | No |
| 120 | GCGR | NA | GCGR Entrez, Source | glucagon receptor | 19329 | -0.253 | 0.1621 | No |
| 121 | GPR37 | NA | GPR37 Entrez, Source | G protein-coupled receptor 37 (endothelin receptor type B-like) | 19356 | -0.255 | 0.1624 | No |
| 122 | CHGA | NA | CHGA Entrez, Source | chromogranin A (parathyroid secretory protein 1) | 19395 | -0.260 | 0.1623 | No |
| 123 | NEBL | NA | NEBL Entrez, Source | nebulette | 19813 | -0.301 | 0.1485 | No |
| 124 | KCNA5 | NA | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 19949 | -0.315 | 0.1452 | No |
| 125 | RCAN2 | NA | 20320 | -0.358 | 0.1334 | No | ||
| 126 | GPNMB | NA | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 20342 | -0.361 | 0.1345 | No |
| 127 | CRYM | NA | CRYM Entrez, Source | crystallin, mu | 20899 | -0.437 | 0.1163 | No |
| 128 | OCLM | NA | OCLM Entrez, Source | oculomedin | 21619 | -0.555 | 0.0927 | No |
| 129 | SCG5 | NA | SCG5 Entrez, Source | secretogranin V (7B2 protein) | 23141 | -0.867 | 0.0412 | No |
| 130 | NUDT11 | NA | NUDT11 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | 23655 | -0.994 | 0.0274 | No |
| 131 | CPEB3 | NA | CPEB3 Entrez, Source | cytoplasmic polyadenylation element binding protein 3 | 24027 | -1.096 | 0.0193 | No |
| 132 | SNAP91 | NA | SNAP91 Entrez, Source | synaptosomal-associated protein, 91kDa homolog (mouse) | 24696 | -1.307 | 0.0015 | No |
| 133 | MPZL2 | NA | 25504 | -1.643 | -0.0198 | No | ||
| 134 | SLC6A15 | NA | SLC6A15 Entrez, Source | solute carrier family 6, member 15 | 25846 | -1.821 | -0.0230 | No |
| 135 | ERC2 | NA | ERC2 Entrez, Source | ELKS/RAB6-interacting/CAST family member 2 | 25870 | -1.839 | -0.0145 | No |
| 136 | SYT1 | NA | SYT1 Entrez, Source | synaptotagmin I | 26109 | -1.987 | -0.0131 | No |
| 137 | NAP1L2 | NA | NAP1L2 Entrez, Source | nucleosome assembly protein 1-like 2 | 26330 | -2.152 | -0.0102 | No |
| 138 | MAP7 | NA | MAP7 Entrez, Source | microtubule-associated protein 7 | 26837 | -2.718 | -0.0149 | No |
| 139 | ITGBL1 | NA | ITGBL1 Entrez, Source | integrin, beta-like 1 (with EGF-like repeat domains) | 26841 | -2.730 | -0.0010 | No |
| 140 | RNLS | NA | 27184 | -3.699 | 0.0053 | No |
