Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | KRAS.LUNG_UP.V1_UP |
| Enrichment Score (ES) | -0.28118145 |
| Normalized Enrichment Score (NES) | -1.3984427 |
| Nominal p-value | 0.010548524 |
| FDR q-value | 0.18094583 |
| FWER p-Value | 0.526 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MT3 | NA | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 0 | 4.375 | 0.0347 | No |
| 2 | LRIG1 | NA | LRIG1 Entrez, Source | leucine-rich repeats and immunoglobulin-like domains 1 | 137 | 3.386 | 0.0565 | No |
| 3 | NES | NA | NES Entrez, Source | nestin | 363 | 2.979 | 0.0718 | No |
| 4 | PCDH17 | NA | PCDH17 Entrez, Source | protocadherin 17 | 384 | 2.950 | 0.0944 | No |
| 5 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 718 | 2.553 | 0.1024 | No |
| 6 | SARM1 | NA | SARM1 Entrez, Source | sterile alpha and TIR motif containing 1 | 811 | 2.465 | 0.1186 | No |
| 7 | ANGPTL4 | NA | ANGPTL4 Entrez, Source | angiopoietin-like 4 | 866 | 2.417 | 0.1357 | No |
| 8 | ST3GAL6 | NA | ST3GAL6 Entrez, Source | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 923 | 2.370 | 0.1524 | No |
| 9 | CYP2J2 | NA | CYP2J2 Entrez, Source | cytochrome P450, family 2, subfamily J, polypeptide 2 | 984 | 2.325 | 0.1686 | No |
| 10 | KIF5C | NA | KIF5C Entrez, Source | kinesin family member 5C | 1092 | 2.248 | 0.1825 | No |
| 11 | C11orf41 | NA | C11ORF41 Entrez, Source | chromosome 11 open reading frame 41 | 1164 | 2.200 | 0.1973 | No |
| 12 | OGDHL | NA | OGDHL Entrez, Source | oxoglutarate dehydrogenase-like | 1296 | 2.103 | 0.2092 | No |
| 13 | HOXD11 | NA | HOXD11 Entrez, Source | homeobox D11 | 1307 | 2.095 | 0.2254 | No |
| 14 | FABP3 | NA | FABP3 Entrez, Source | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | 1573 | 1.939 | 0.2310 | No |
| 15 | DOCK4 | NA | DOCK4 Entrez, Source | dedicator of cytokinesis 4 | 1989 | 1.731 | 0.2295 | No |
| 16 | WNT7A | NA | WNT7A Entrez, Source | wingless-type MMTV integration site family, member 7A | 2246 | 1.618 | 0.2329 | No |
| 17 | TMEM176B | NA | TMEM176B Entrez, Source | transmembrane protein 176B | 2498 | 1.506 | 0.2356 | No |
| 18 | ADAMTS3 | NA | ADAMTS3 Entrez, Source | ADAM metallopeptidase with thrombospondin type 1 motif, 3 | 2534 | 1.488 | 0.2461 | No |
| 19 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 2555 | 1.479 | 0.2571 | No |
| 20 | NDOR1 | NA | NDOR1 Entrez, Source | NADPH dependent diflavin oxidoreductase 1 | 2809 | 1.383 | 0.2587 | No |
| 21 | RNASE1 | NA | RNASE1 Entrez, Source | ribonuclease, RNase A family, 1 (pancreatic) | 2834 | 1.373 | 0.2687 | No |
| 22 | ZNF821 | NA | 3603 | 1.115 | 0.2493 | No | ||
| 23 | SLC18A1 | NA | SLC18A1 Entrez, Source | solute carrier family 18 (vesicular monoamine), member 1 | 3725 | 1.075 | 0.2534 | No |
| 24 | CG030 | NA | CG030 Entrez, Source | - | 3989 | 0.989 | 0.2515 | No |
| 25 | IL13RA2 | NA | IL13RA2 Entrez, Source | interleukin 13 receptor, alpha 2 | 4557 | 0.849 | 0.2374 | No |
| 26 | HBEGF | NA | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 4667 | 0.821 | 0.2399 | No |
| 27 | LAG3 | NA | LAG3 Entrez, Source | lymphocyte-activation gene 3 | 4789 | 0.792 | 0.2417 | No |
| 28 | ZNF639 | NA | ZNF639 Entrez, Source | zinc finger protein 639 | 4845 | 0.777 | 0.2459 | No |
| 29 | ADCYAP1R1 | NA | ADCYAP1R1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | 4982 | 0.747 | 0.2468 | No |
| 30 | NKX2-5 | NA | NKX2-5 Entrez, Source | NK2 transcription factor related, locus 5 (Drosophila) | 5260 | 0.674 | 0.2419 | No |
| 31 | SLC16A8 | NA | SLC16A8 Entrez, Source | solute carrier family 16, member 8 (monocarboxylic acid transporter 3) | 5732 | 0.573 | 0.2292 | No |
| 32 | CLEC4A | NA | CLEC4A Entrez, Source | C-type lectin domain family 4, member A | 6642 | 0.436 | 0.1992 | No |
| 33 | LDB3 | NA | LDB3 Entrez, Source | LIM domain binding 3 | 7560 | 0.339 | 0.1681 | No |
| 34 | NGF | NA | 7575 | 0.338 | 0.1703 | No | ||
| 35 | HPN | NA | HPN Entrez, Source | hepsin (transmembrane protease, serine 1) | 7770 | 0.321 | 0.1657 | No |
| 36 | POLM | NA | POLM Entrez, Source | polymerase (DNA directed), mu | 7835 | 0.315 | 0.1659 | No |
| 37 | GRIP2 | NA | GRIP2 Entrez, Source | glutamate receptor interacting protein 2 | 8064 | 0.295 | 0.1598 | No |
| 38 | RBP4 | NA | RBP4 Entrez, Source | retinol binding protein 4, plasma | 8284 | 0.278 | 0.1540 | No |
| 39 | TEX13A | NA | TEX13A Entrez, Source | testis expressed sequence 13A | 8513 | 0.262 | 0.1477 | No |
| 40 | CELA2B | NA | 8879 | 0.237 | 0.1361 | No | ||
| 41 | TTC22 | NA | TTC22 Entrez, Source | tetratricopeptide repeat domain 22 | 9223 | 0.218 | 0.1252 | No |
| 42 | ABCB1 | NA | ABCB1 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 9255 | 0.216 | 0.1258 | No |
| 43 | IKZF1 | NA | IKZF1 Entrez, Source | IKAROS family zinc finger 1 (Ikaros) | 9279 | 0.215 | 0.1267 | No |
| 44 | ANO1 | NA | 9757 | 0.190 | 0.1106 | No | ||
| 45 | PAX4 | NA | PAX4 Entrez, Source | paired box gene 4 | 9836 | 0.186 | 0.1092 | No |
| 46 | TNNT2 | NA | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 10748 | 0.144 | 0.0769 | No |
| 47 | FUT5 | NA | FUT5 Entrez, Source | fucosyltransferase 5 (alpha (1,3) fucosyltransferase) | 10779 | 0.142 | 0.0769 | No |
| 48 | FNDC8 | NA | FNDC8 Entrez, Source | fibronectin type III domain containing 8 | 10863 | 0.139 | 0.0749 | No |
| 49 | CYP4F8 | NA | CYP4F8 Entrez, Source | cytochrome P450, family 4, subfamily F, polypeptide 8 | 10913 | 0.137 | 0.0742 | No |
| 50 | SLC6A11 | NA | SLC6A11 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, GABA), member 11 | 11087 | 0.128 | 0.0689 | No |
| 51 | OR2B6 | NA | OR2B6 Entrez, Source | olfactory receptor, family 2, subfamily B, member 6 | 11131 | 0.126 | 0.0683 | No |
| 52 | SEMG2 | NA | SEMG2 Entrez, Source | semenogelin II | 11164 | 0.125 | 0.0681 | No |
| 53 | ASGR2 | NA | ASGR2 Entrez, Source | asialoglycoprotein receptor 2 | 11670 | 0.103 | 0.0504 | No |
| 54 | INHBA | NA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 11814 | 0.097 | 0.0459 | No |
| 55 | CECR1 | NA | CECR1 Entrez, Source | cat eye syndrome chromosome region, candidate 1 | 11840 | 0.096 | 0.0457 | No |
| 56 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 12340 | 0.077 | 0.0280 | No |
| 57 | PRKG2 | NA | PRKG2 Entrez, Source | protein kinase, cGMP-dependent, type II | 12361 | 0.076 | 0.0278 | No |
| 58 | CCL20 | NA | CCL20 Entrez, Source | chemokine (C-C motif) ligand 20 | 12374 | 0.076 | 0.0280 | No |
| 59 | CCT8L2 | NA | 12412 | 0.074 | 0.0272 | No | ||
| 60 | CD247 | NA | CD247 Entrez, Source | CD247 molecule | 12530 | 0.070 | 0.0235 | No |
| 61 | LOC157627 | NA | LOC157627 Entrez, Source | - | 13171 | 0.046 | 0.0003 | No |
| 62 | MYH2 | NA | MYH2 Entrez, Source | myosin, heavy chain 2, skeletal muscle, adult | 13245 | 0.043 | -0.0020 | No |
| 63 | NPHS1 | NA | NPHS1 Entrez, Source | nephrosis 1, congenital, Finnish type (nephrin) | 13321 | 0.040 | -0.0045 | No |
| 64 | CD48 | NA | CD48 Entrez, Source | CD48 molecule | 13342 | 0.040 | -0.0049 | No |
| 65 | CRYAA | NA | CRYAA Entrez, Source | crystallin, alpha A | 13643 | 0.028 | -0.0157 | No |
| 66 | DOCK2 | NA | DOCK2 Entrez, Source | dedicator of cytokinesis 2 | 13996 | 0.015 | -0.0285 | No |
| 67 | RELN | NA | RELN Entrez, Source | reelin | 14279 | 0.005 | -0.0388 | No |
| 68 | TAS2R1 | NA | TAS2R1 Entrez, Source | taste receptor, type 2, member 1 | 14306 | 0.004 | -0.0398 | No |
| 69 | RETN | NA | RETN Entrez, Source | resistin | 14399 | 0.001 | -0.0431 | No |
| 70 | CX3CR1 | NA | CX3CR1 Entrez, Source | chemokine (C-X3-C motif) receptor 1 | 14724 | -0.011 | -0.0550 | No |
| 71 | MMP20 | NA | MMP20 Entrez, Source | matrix metallopeptidase 20 (enamelysin) | 15153 | -0.027 | -0.0705 | No |
| 72 | FRMD1 | NA | FRMD1 Entrez, Source | FERM domain containing 1 | 15484 | -0.040 | -0.0823 | No |
| 73 | IL8 | NA | IL8 Entrez, Source | interleukin 8 | 15907 | -0.056 | -0.0974 | No |
| 74 | PPP1R14D | NA | PPP1R14D Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 14D | 16062 | -0.062 | -0.1026 | No |
| 75 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 16554 | -0.083 | -0.1200 | No |
| 76 | GRIN2A | NA | GRIN2A Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 16591 | -0.084 | -0.1206 | No |
| 77 | ALLC | NA | ALLC Entrez, Source | allantoicase | 16670 | -0.088 | -0.1228 | No |
| 78 | C7orf63 | NA | 16691 | -0.089 | -0.1228 | No | ||
| 79 | LILRB1 | NA | LILRB1 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 16826 | -0.094 | -0.1270 | No |
| 80 | AURKC | NA | AURKC Entrez, Source | aurora kinase C | 16856 | -0.096 | -0.1273 | No |
| 81 | BANK1 | NA | BANK1 Entrez, Source | B-cell scaffold protein with ankyrin repeats 1 | 17554 | -0.127 | -0.1519 | No |
| 82 | SLC6A4 | NA | SLC6A4 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 17580 | -0.128 | -0.1518 | No |
| 83 | HSD11B1 | NA | HSD11B1 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 1 | 17896 | -0.147 | -0.1623 | No |
| 84 | DEFA5 | NA | DEFA5 Entrez, Source | defensin, alpha 5, Paneth cell-specific | 18021 | -0.154 | -0.1656 | No |
| 85 | CD1A | NA | CD1A Entrez, Source | CD1a molecule | 18355 | -0.175 | -0.1764 | No |
| 86 | SIGLEC15 | NA | 18395 | -0.178 | -0.1765 | No | ||
| 87 | CYTIP | NA | 18503 | -0.186 | -0.1789 | No | ||
| 88 | GBA3 | NA | GBA3 Entrez, Source | glucosidase, beta, acid 3 (cytosolic) | 19138 | -0.238 | -0.2004 | No |
| 89 | IL1RL1 | NA | IL1RL1 Entrez, Source | interleukin 1 receptor-like 1 | 19520 | -0.272 | -0.2122 | No |
| 90 | SMPX | NA | SMPX Entrez, Source | small muscle protein, X-linked | 19685 | -0.288 | -0.2160 | No |
| 91 | PRG3 | NA | PRG3 Entrez, Source | proteoglycan 3 | 19742 | -0.294 | -0.2157 | No |
| 92 | NTM | NA | 19833 | -0.303 | -0.2166 | No | ||
| 93 | KCNA5 | NA | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 19949 | -0.315 | -0.2183 | No |
| 94 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 20150 | -0.337 | -0.2230 | No |
| 95 | GPR3 | NA | GPR3 Entrez, Source | G protein-coupled receptor 3 | 20303 | -0.356 | -0.2258 | No |
| 96 | ATG10 | NA | ATG10 Entrez, Source | ATG10 autophagy related 10 homolog (S. cerevisiae) | 20685 | -0.404 | -0.2366 | No |
| 97 | IGSF1 | NA | IGSF1 Entrez, Source | immunoglobulin superfamily, member 1 | 20751 | -0.415 | -0.2357 | No |
| 98 | ADAM8 | NA | ADAM8 Entrez, Source | ADAM metallopeptidase domain 8 | 20906 | -0.438 | -0.2379 | No |
| 99 | CLSTN3 | NA | CLSTN3 Entrez, Source | calsyntenin 3 | 20943 | -0.444 | -0.2357 | No |
| 100 | PDCD1LG2 | NA | PDCD1LG2 Entrez, Source | programmed cell death 1 ligand 2 | 21180 | -0.478 | -0.2406 | No |
| 101 | RGS4 | NA | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 21333 | -0.503 | -0.2422 | No |
| 102 | SH2D2A | NA | SH2D2A Entrez, Source | SH2 domain protein 2A | 21557 | -0.545 | -0.2461 | No |
| 103 | ZBTB48 | NA | ZBTB48 Entrez, Source | zinc finger and BTB domain containing 48 | 21670 | -0.564 | -0.2457 | No |
| 104 | BCL2A1 | NA | BCL2A1 Entrez, Source | BCL2-related protein A1 | 21683 | -0.567 | -0.2417 | No |
| 105 | ZNF749 | NA | ZNF749 Entrez, Source | zinc finger protein 749 | 22020 | -0.632 | -0.2490 | No |
| 106 | EGFL7 | NA | EGFL7 Entrez, Source | EGF-like-domain, multiple 7 | 22291 | -0.686 | -0.2535 | No |
| 107 | NELL2 | NA | NELL2 Entrez, Source | NEL-like 2 (chicken) | 22466 | -0.721 | -0.2542 | No |
| 108 | SDCCAG8 | NA | SDCCAG8 Entrez, Source | serologically defined colon cancer antigen 8 | 22608 | -0.756 | -0.2534 | No |
| 109 | DCBLD2 | NA | DCBLD2 Entrez, Source | discoidin, CUB and LCCL domain containing 2 | 22793 | -0.793 | -0.2539 | No |
| 110 | C17orf53 | NA | C17ORF53 Entrez, Source | chromosome 17 open reading frame 53 | 22874 | -0.812 | -0.2504 | No |
| 111 | SCG5 | NA | SCG5 Entrez, Source | secretogranin V (7B2 protein) | 23141 | -0.867 | -0.2533 | No |
| 112 | JAK3 | NA | JAK3 Entrez, Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 23405 | -0.927 | -0.2556 | No |
| 113 | TSPAN1 | NA | TSPAN1 Entrez, Source | tetraspanin 1 | 23502 | -0.951 | -0.2516 | No |
| 114 | ETS1 | NA | ETS1 Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 24224 | -1.157 | -0.2690 | No |
| 115 | CSF3 | NA | CSF3 Entrez, Source | colony stimulating factor 3 (granulocyte) | 24446 | -1.225 | -0.2674 | No |
| 116 | BTC | NA | BTC Entrez, Source | betacellulin | 24641 | -1.291 | -0.2643 | No |
| 117 | PTPRR | NA | PTPRR Entrez, Source | protein tyrosine phosphatase, receptor type, R | 25101 | -1.465 | -0.2696 | Yes |
| 118 | ZBTB44 | NA | ZBTB44 Entrez, Source | zinc finger and BTB domain containing 44 | 25280 | -1.538 | -0.2639 | Yes |
| 119 | B3GNTL1 | NA | B3GNTL1 Entrez, Source | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | 25465 | -1.623 | -0.2578 | Yes |
| 120 | SLCO5A1 | NA | SLCO5A1 Entrez, Source | solute carrier organic anion transporter family, member 5A1 | 25484 | -1.634 | -0.2456 | Yes |
| 121 | TBX3 | NA | TBX3 Entrez, Source | T-box 3 (ulnar mammary syndrome) | 25487 | -1.638 | -0.2327 | Yes |
| 122 | FBXO4 | NA | FBXO4 Entrez, Source | F-box protein 4 | 25771 | -1.778 | -0.2290 | Yes |
| 123 | IL23A | NA | IL23A Entrez, Source | interleukin 23, alpha subunit p19 | 25913 | -1.862 | -0.2194 | Yes |
| 124 | SLCO4A1 | NA | SLCO4A1 Entrez, Source | solute carrier organic anion transporter family, member 4A1 | 25930 | -1.874 | -0.2052 | Yes |
| 125 | HTR7 | NA | HTR7 Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) | 26240 | -2.081 | -0.2000 | Yes |
| 126 | TMEM158 | NA | TMEM158 Entrez, Source | transmembrane protein 158 | 26610 | -2.396 | -0.1946 | Yes |
| 127 | G0S2 | NA | G0S2 Entrez, Source | G0/G1switch 2 | 26789 | -2.628 | -0.1804 | Yes |
| 128 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 26913 | -2.831 | -0.1625 | Yes |
| 129 | MMP1 | NA | MMP1 Entrez, Source | matrix metallopeptidase 1 (interstitial collagenase) | 27012 | -3.065 | -0.1418 | Yes |
| 130 | EVI2A | NA | EVI2A Entrez, Source | ecotropic viral integration site 2A | 27034 | -3.146 | -0.1176 | Yes |
| 131 | NAV3 | NA | NAV3 Entrez, Source | neuron navigator 3 | 27085 | -3.304 | -0.0933 | Yes |
| 132 | CXCL5 | NA | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 27183 | -3.696 | -0.0676 | Yes |
| 133 | HS3ST3A1 | NA | HS3ST3A1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 27265 | -4.264 | -0.0368 | Yes |
| 134 | MAGEA6 | NA | MAGEA6 Entrez, Source | melanoma antigen family A, 6 | 27329 | -4.936 | 0.0000 | Yes |
