Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | KRAS.PROSTATE_UP.V1_DN |
| Enrichment Score (ES) | 0.4986635 |
| Normalized Enrichment Score (NES) | 1.7233266 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.004749066 |
| FWER p-Value | 0.019 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | C5 | NA | C5 Entrez, Source | complement component 5 | 15 | 3.923 | 0.0363 | Yes |
| 2 | PLCB1 | NA | PLCB1 Entrez, Source | phospholipase C, beta 1 (phosphoinositide-specific) | 193 | 3.282 | 0.0607 | Yes |
| 3 | IGFBP3 | NA | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 206 | 3.262 | 0.0909 | Yes |
| 4 | SMO | NA | SMO Entrez, Source | smoothened homolog (Drosophila) | 289 | 3.103 | 0.1171 | Yes |
| 5 | BEND5 | NA | 513 | 2.775 | 0.1350 | Yes | ||
| 6 | CXCR7 | NA | CXCR7 Entrez, Source | chemokine (C-X-C motif) receptor 7 | 520 | 2.766 | 0.1608 | Yes |
| 7 | KCNA2 | NA | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 563 | 2.703 | 0.1847 | Yes |
| 8 | IDUA | NA | IDUA Entrez, Source | iduronidase, alpha-L- | 901 | 2.389 | 0.1947 | Yes |
| 9 | CGREF1 | NA | CGREF1 Entrez, Source | cell growth regulator with EF-hand domain 1 | 924 | 2.368 | 0.2162 | Yes |
| 10 | PPP1R9A | NA | PPP1R9A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 9A | 1137 | 2.220 | 0.2293 | Yes |
| 11 | ZBTB16 | NA | ZBTB16 Entrez, Source | zinc finger and BTB domain containing 16 | 1236 | 2.142 | 0.2458 | Yes |
| 12 | EGF | NA | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 1262 | 2.127 | 0.2649 | Yes |
| 13 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 1268 | 2.123 | 0.2847 | Yes |
| 14 | CAMK1D | NA | CAMK1D Entrez, Source | calcium/calmodulin-dependent protein kinase ID | 1282 | 2.112 | 0.3041 | Yes |
| 15 | CADM4 | NA | 1354 | 2.071 | 0.3209 | Yes | ||
| 16 | REEP1 | NA | REEP1 Entrez, Source | receptor accessory protein 1 | 1473 | 1.994 | 0.3354 | Yes |
| 17 | FLRT1 | NA | FLRT1 Entrez, Source | fibronectin leucine rich transmembrane protein 1 | 1805 | 1.820 | 0.3403 | Yes |
| 18 | LUM | NA | LUM Entrez, Source | lumican | 1858 | 1.798 | 0.3553 | Yes |
| 19 | SLC26A10 | NA | SLC26A10 Entrez, Source | solute carrier family 26, member 10 | 1892 | 1.779 | 0.3708 | Yes |
| 20 | ADAM23 | NA | ADAM23 Entrez, Source | ADAM metallopeptidase domain 23 | 1922 | 1.765 | 0.3864 | Yes |
| 21 | NDP | NA | NDP Entrez, Source | Norrie disease (pseudoglioma) | 2112 | 1.672 | 0.3951 | Yes |
| 22 | YBX2 | NA | YBX2 Entrez, Source | Y box binding protein 2 | 2615 | 1.454 | 0.3904 | Yes |
| 23 | POU3F2 | NA | POU3F2 Entrez, Source | POU domain, class 3, transcription factor 2 | 2684 | 1.428 | 0.4013 | Yes |
| 24 | EPHX2 | NA | EPHX2 Entrez, Source | epoxide hydrolase 2, cytoplasmic | 2718 | 1.416 | 0.4134 | Yes |
| 25 | RGS6 | NA | RGS6 Entrez, Source | regulator of G-protein signalling 6 | 2877 | 1.359 | 0.4204 | Yes |
| 26 | CRY2 | NA | CRY2 Entrez, Source | cryptochrome 2 (photolyase-like) | 2892 | 1.354 | 0.4326 | Yes |
| 27 | PTH1R | NA | 3116 | 1.272 | 0.4363 | Yes | ||
| 28 | VGLL3 | NA | VGLL3 Entrez, Source | vestigial like 3 (Drosophila) | 3246 | 1.226 | 0.4431 | Yes |
| 29 | SLC30A4 | NA | SLC30A4 Entrez, Source | solute carrier family 30 (zinc transporter), member 4 | 3257 | 1.224 | 0.4543 | Yes |
| 30 | KCNQ2 | NA | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 3310 | 1.211 | 0.4637 | Yes |
| 31 | DIRAS3 | NA | DIRAS3 Entrez, Source | DIRAS family, GTP-binding RAS-like 3 | 3323 | 1.208 | 0.4747 | Yes |
| 32 | PTGIS | NA | PTGIS Entrez, Source | prostaglandin I2 (prostacyclin) synthase | 3362 | 1.196 | 0.4845 | Yes |
| 33 | ITGB1BP2 | NA | ITGB1BP2 Entrez, Source | integrin beta 1 binding protein (melusin) 2 | 3379 | 1.191 | 0.4951 | Yes |
| 34 | EDN1 | NA | EDN1 Entrez, Source | endothelin 1 | 3804 | 1.049 | 0.4894 | Yes |
| 35 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 3820 | 1.043 | 0.4987 | Yes |
| 36 | HDLBP | NA | HDLBP Entrez, Source | high density lipoprotein binding protein (vigilin) | 4447 | 0.872 | 0.4838 | No |
| 37 | GRM2 | NA | GRM2 Entrez, Source | glutamate receptor, metabotropic 2 | 4527 | 0.855 | 0.4890 | No |
| 38 | TFAP2B | NA | TFAP2B Entrez, Source | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) | 4743 | 0.802 | 0.4886 | No |
| 39 | SLC19A3 | NA | SLC19A3 Entrez, Source | solute carrier family 19, member 3 | 4974 | 0.748 | 0.4872 | No |
| 40 | MAFB | NA | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 5115 | 0.716 | 0.4888 | No |
| 41 | AK5 | NA | AK5 Entrez, Source | adenylate kinase 5 | 5289 | 0.665 | 0.4887 | No |
| 42 | KLF1 | NA | KLF1 Entrez, Source | Kruppel-like factor 1 (erythroid) | 5437 | 0.631 | 0.4892 | No |
| 43 | CA5B | NA | CA5B Entrez, Source | carbonic anhydrase VB, mitochondrial | 6013 | 0.524 | 0.4730 | No |
| 44 | MUC4 | NA | MUC4 Entrez, Source | mucin 4, cell surface associated | 6474 | 0.456 | 0.4604 | No |
| 45 | GNGT2 | NA | GNGT2 Entrez, Source | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 | 6711 | 0.427 | 0.4557 | No |
| 46 | MAGIX | NA | 6746 | 0.424 | 0.4584 | No | ||
| 47 | RASGRP1 | NA | RASGRP1 Entrez, Source | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 6957 | 0.401 | 0.4545 | No |
| 48 | SLC4A8 | NA | SLC4A8 Entrez, Source | solute carrier family 4, sodium bicarbonate cotransporter, member 8 | 7184 | 0.377 | 0.4497 | No |
| 49 | NR0B2 | NA | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 7411 | 0.353 | 0.4447 | No |
| 50 | CLDN17 | NA | CLDN17 Entrez, Source | claudin 17 | 7667 | 0.329 | 0.4384 | No |
| 51 | COLEC10 | NA | COLEC10 Entrez, Source | collectin sub-family member 10 (C-type lectin) | 7976 | 0.303 | 0.4300 | No |
| 52 | PRTN3 | NA | PRTN3 Entrez, Source | proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) | 8235 | 0.283 | 0.4231 | No |
| 53 | C22orf31 | NA | C22ORF31 Entrez, Source | chromosome 22 open reading frame 31 | 8242 | 0.282 | 0.4256 | No |
| 54 | SSTR4 | NA | SSTR4 Entrez, Source | somatostatin receptor 4 | 8311 | 0.276 | 0.4257 | No |
| 55 | NCR3 | NA | NCR3 Entrez, Source | natural cytotoxicity triggering receptor 3 | 8890 | 0.237 | 0.4066 | No |
| 56 | SDS | NA | SDS Entrez, Source | serine dehydratase | 9038 | 0.228 | 0.4034 | No |
| 57 | ASIP | NA | ASIP Entrez, Source | agouti signaling protein, nonagouti homolog (mouse) | 9122 | 0.223 | 0.4024 | No |
| 58 | IL19 | NA | IL19 Entrez, Source | interleukin 19 | 9225 | 0.218 | 0.4007 | No |
| 59 | ABCB1 | NA | ABCB1 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 9255 | 0.216 | 0.4017 | No |
| 60 | MAOB | NA | MAOB Entrez, Source | monoamine oxidase B | 9285 | 0.215 | 0.4026 | No |
| 61 | KRT13 | NA | KRT13 Entrez, Source | keratin 13 | 9639 | 0.195 | 0.3915 | No |
| 62 | KIAA0087 | NA | KIAA0087 Entrez, Source | - | 9644 | 0.195 | 0.3932 | No |
| 63 | CD96 | NA | CD96 Entrez, Source | CD96 molecule | 10029 | 0.178 | 0.3807 | No |
| 64 | ARG1 | NA | ARG1 Entrez, Source | arginase, liver | 10376 | 0.161 | 0.3695 | No |
| 65 | SOD3 | NA | SOD3 Entrez, Source | superoxide dismutase 3, extracellular | 10502 | 0.155 | 0.3664 | No |
| 66 | PF4V1 | NA | PF4V1 Entrez, Source | platelet factor 4 variant 1 | 10717 | 0.145 | 0.3599 | No |
| 67 | GCNT3 | NA | GCNT3 Entrez, Source | glucosaminyl (N-acetyl) transferase 3, mucin type | 10756 | 0.143 | 0.3598 | No |
| 68 | MLANA | NA | MLANA Entrez, Source | melan-A | 10870 | 0.138 | 0.3570 | No |
| 69 | OXT | NA | OXT Entrez, Source | oxytocin, prepro- (neurophysin I) | 10952 | 0.135 | 0.3553 | No |
| 70 | SPRR1A | NA | SPRR1A Entrez, Source | small proline-rich protein 1A | 11314 | 0.117 | 0.3431 | No |
| 71 | CRYGD | NA | CRYGD Entrez, Source | crystallin, gamma D | 11380 | 0.114 | 0.3418 | No |
| 72 | KRT16 | NA | KRT16 Entrez, Source | keratin 16 (focal non-epidermolytic palmoplantar keratoderma) | 11408 | 0.113 | 0.3419 | No |
| 73 | TAGLN | NA | TAGLN Entrez, Source | transgelin | 11571 | 0.108 | 0.3369 | No |
| 74 | FBXO40 | NA | FBXO40 Entrez, Source | F-box protein 40 | 11846 | 0.096 | 0.3277 | No |
| 75 | ACSS3 | NA | 12033 | 0.089 | 0.3217 | No | ||
| 76 | CWH43 | NA | 12283 | 0.080 | 0.3133 | No | ||
| 77 | SERPINB2 | NA | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 12515 | 0.070 | 0.3055 | No |
| 78 | NPBWR2 | NA | NPBWR2 Entrez, Source | neuropeptides B/W receptor 2 | 12581 | 0.068 | 0.3038 | No |
| 79 | CCR10 | NA | CCR10 Entrez, Source | chemokine (C-C motif) receptor 10 | 12792 | 0.061 | 0.2966 | No |
| 80 | S100A8 | NA | S100A8 Entrez, Source | S100 calcium binding protein A8 | 12854 | 0.059 | 0.2949 | No |
| 81 | LCN2 | NA | LCN2 Entrez, Source | lipocalin 2 (oncogene 24p3) | 12922 | 0.056 | 0.2930 | No |
| 82 | MGC40069 | NA | MGC40069 Entrez, Source | - | 12999 | 0.053 | 0.2907 | No |
| 83 | LHCGR | NA | LHCGR Entrez, Source | luteinizing hormone/choriogonadotropin receptor | 13073 | 0.050 | 0.2885 | No |
| 84 | SPRR1B | NA | SPRR1B Entrez, Source | small proline-rich protein 1B (cornifin) | 13126 | 0.048 | 0.2870 | No |
| 85 | ITGB7 | NA | ITGB7 Entrez, Source | integrin, beta 7 | 13270 | 0.042 | 0.2821 | No |
| 86 | NPHS1 | NA | NPHS1 Entrez, Source | nephrosis 1, congenital, Finnish type (nephrin) | 13321 | 0.040 | 0.2807 | No |
| 87 | CD48 | NA | CD48 Entrez, Source | CD48 molecule | 13342 | 0.040 | 0.2803 | No |
| 88 | IBSP | NA | IBSP Entrez, Source | integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) | 13639 | 0.028 | 0.2697 | No |
| 89 | CDH16 | NA | CDH16 Entrez, Source | cadherin 16, KSP-cadherin | 13744 | 0.024 | 0.2661 | No |
| 90 | KLKB1 | NA | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 13759 | 0.024 | 0.2658 | No |
| 91 | KRT4 | NA | KRT4 Entrez, Source | keratin 4 | 13946 | 0.017 | 0.2591 | No |
| 92 | SOX10 | NA | SOX10 Entrez, Source | SRY (sex determining region Y)-box 10 | 13949 | 0.017 | 0.2592 | No |
| 93 | NOS1 | NA | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 14403 | 0.001 | 0.2426 | No |
| 94 | PI3 | NA | PI3 Entrez, Source | peptidase inhibitor 3, skin-derived (SKALP) | 14692 | -0.009 | 0.2321 | No |
| 95 | VIL1 | NA | VIL1 Entrez, Source | villin 1 | 15039 | -0.023 | 0.2196 | No |
| 96 | NTF3 | NA | NTF3 Entrez, Source | neurotrophin 3 | 15279 | -0.032 | 0.2111 | No |
| 97 | ZNF750 | NA | ZNF750 Entrez, Source | zinc finger protein 750 | 15668 | -0.047 | 0.1973 | No |
| 98 | GKN1 | NA | GKN1 Entrez, Source | gastrokine 1 | 15828 | -0.053 | 0.1919 | No |
| 99 | TRH | NA | TRH Entrez, Source | thyrotropin-releasing hormone | 16401 | -0.077 | 0.1716 | No |
| 100 | MUC16 | NA | MUC16 Entrez, Source | mucin 16, cell surface associated | 16408 | -0.078 | 0.1721 | No |
| 101 | SCEL | NA | SCEL Entrez, Source | sciellin | 16633 | -0.086 | 0.1647 | No |
| 102 | HBA2 | NA | HBA2 Entrez, Source | hemoglobin, alpha 2 | 16895 | -0.097 | 0.1560 | No |
| 103 | SLC6A14 | NA | SLC6A14 Entrez, Source | solute carrier family 6 (amino acid transporter), member 14 | 17324 | -0.116 | 0.1414 | No |
| 104 | JMJD5 | NA | JMJD5 Entrez, Source | jumonji domain containing 5 | 17406 | -0.120 | 0.1395 | No |
| 105 | RRAD | NA | RRAD Entrez, Source | Ras-related associated with diabetes | 17691 | -0.134 | 0.1303 | No |
| 106 | S100A7 | NA | S100A7 Entrez, Source | S100 calcium binding protein A7 | 18221 | -0.167 | 0.1124 | No |
| 107 | C1orf68 | NA | C1ORF68 Entrez, Source | chromosome 1 open reading frame 68 | 18371 | -0.176 | 0.1086 | No |
| 108 | FOLH1B | NA | 18549 | -0.189 | 0.1039 | No | ||
| 109 | ARHGAP28 | NA | ARHGAP28 Entrez, Source | Rho GTPase activating protein 28 | 19016 | -0.228 | 0.0889 | No |
| 110 | OPCML | NA | OPCML Entrez, Source | opioid binding protein/cell adhesion molecule-like | 19073 | -0.233 | 0.0890 | No |
| 111 | FOXD2 | NA | FOXD2 Entrez, Source | forkhead box D2 | 19435 | -0.263 | 0.0782 | No |
| 112 | SPRR3 | NA | SPRR3 Entrez, Source | small proline-rich protein 3 | 19850 | -0.305 | 0.0659 | No |
| 113 | GPRASP1 | NA | GPRASP1 Entrez, Source | G protein-coupled receptor associated sorting protein 1 | 20301 | -0.355 | 0.0527 | No |
| 114 | GPNMB | NA | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 20342 | -0.361 | 0.0546 | No |
| 115 | CTSE | NA | CTSE Entrez, Source | cathepsin E | 20401 | -0.368 | 0.0559 | No |
| 116 | RAI1 | NA | RAI1 Entrez, Source | retinoic acid induced 1 | 21050 | -0.460 | 0.0364 | No |
| 117 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 21288 | -0.495 | 0.0323 | No |
| 118 | TUBAL3 | NA | TUBAL3 Entrez, Source | tubulin, alpha-like 3 | 21440 | -0.524 | 0.0317 | No |
| 119 | CFI | NA | CFI Entrez, Source | complement factor I | 21672 | -0.565 | 0.0285 | No |
| 120 | TTC21B | NA | TTC21B Entrez, Source | tetratricopeptide repeat domain 21B | 21748 | -0.581 | 0.0312 | No |
| 121 | CCDC134 | NA | 21960 | -0.622 | 0.0293 | No | ||
| 122 | SH2D3C | NA | SH2D3C Entrez, Source | SH2 domain containing 3C | 22304 | -0.688 | 0.0232 | No |
| 123 | NEU3 | NA | NEU3 Entrez, Source | sialidase 3 (membrane sialidase) | 22517 | -0.733 | 0.0223 | No |
| 124 | TGM1 | NA | TGM1 Entrez, Source | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) | 22653 | -0.766 | 0.0245 | No |
| 125 | PCDHB13 | NA | PCDHB13 Entrez, Source | protocadherin beta 13 | 23088 | -0.856 | 0.0166 | No |
| 126 | KCNJ14 | NA | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 23202 | -0.880 | 0.0207 | No |
| 127 | ATP8B3 | NA | ATP8B3 Entrez, Source | ATPase, Class I, type 8B, member 3 | 23292 | -0.899 | 0.0259 | No |
| 128 | ABCG4 | NA | ABCG4 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 4 | 23526 | -0.958 | 0.0264 | No |
| 129 | SERPINB7 | NA | SERPINB7 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 7 | 23834 | -1.046 | 0.0249 | No |
| 130 | COBL | NA | COBL Entrez, Source | cordon-bleu homolog (mouse) | 24195 | -1.147 | 0.0225 | No |
| 131 | PTPRH | NA | PTPRH Entrez, Source | protein tyrosine phosphatase, receptor type, H | 24444 | -1.224 | 0.0249 | No |
| 132 | AATK | NA | AATK Entrez, Source | apoptosis-associated tyrosine kinase | 24542 | -1.258 | 0.0331 | No |
| 133 | EPHB6 | NA | EPHB6 Entrez, Source | EPH receptor B6 | 25065 | -1.446 | 0.0275 | No |
| 134 | DNAJC12 | NA | DNAJC12 Entrez, Source | DnaJ (Hsp40) homolog, subfamily C, member 12 | 25713 | -1.746 | 0.0201 | No |
| 135 | ENPP1 | NA | ENPP1 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 27252 | -4.172 | 0.0028 | No |
