Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 1 |
| GeneSet | KRAS.PROSTATE_UP.V1_UP |
| Enrichment Score (ES) | 0.43655372 |
| Normalized Enrichment Score (NES) | 1.8166538 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0016306986 |
| FWER p-Value | 0.004 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | JAM2 | NA | JAM2 Entrez, Source | junctional adhesion molecule 2 | 30 | 3.788 | 0.0293 | Yes |
| 2 | FEZ1 | NA | FEZ1 Entrez, Source | fasciculation and elongation protein zeta 1 (zygin I) | 159 | 3.338 | 0.0513 | Yes |
| 3 | ZEB1 | NA | 256 | 3.161 | 0.0731 | Yes | ||
| 4 | NES | NA | NES Entrez, Source | nestin | 363 | 2.979 | 0.0931 | Yes |
| 5 | LMO1 | NA | LMO1 Entrez, Source | LIM domain only 1 (rhombotin 1) | 414 | 2.907 | 0.1146 | Yes |
| 6 | ZNF529 | NA | ZNF529 Entrez, Source | zinc finger protein 529 | 436 | 2.888 | 0.1370 | Yes |
| 7 | REEP2 | NA | REEP2 Entrez, Source | receptor accessory protein 2 | 455 | 2.863 | 0.1593 | Yes |
| 8 | CDH4 | NA | CDH4 Entrez, Source | cadherin 4, type 1, R-cadherin (retinal) | 524 | 2.756 | 0.1789 | Yes |
| 9 | POPDC2 | NA | POPDC2 Entrez, Source | popeye domain containing 2 | 571 | 2.696 | 0.1988 | Yes |
| 10 | MMP11 | NA | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 736 | 2.539 | 0.2131 | Yes |
| 11 | TG | NA | TG Entrez, Source | thyroglobulin | 775 | 2.494 | 0.2317 | Yes |
| 12 | MEGF8 | NA | MEGF8 Entrez, Source | multiple EGF-like-domains 8 | 786 | 2.489 | 0.2513 | Yes |
| 13 | ANGPTL4 | NA | ANGPTL4 Entrez, Source | angiopoietin-like 4 | 866 | 2.417 | 0.2678 | Yes |
| 14 | GRK5 | NA | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 946 | 2.356 | 0.2838 | Yes |
| 15 | HKDC1 | NA | HKDC1 Entrez, Source | hexokinase domain containing 1 | 974 | 2.333 | 0.3015 | Yes |
| 16 | ENG | NA | ENG Entrez, Source | endoglin (Osler-Rendu-Weber syndrome 1) | 1079 | 2.258 | 0.3158 | Yes |
| 17 | MAP3K1 | NA | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 1139 | 2.220 | 0.3314 | Yes |
| 18 | CX3CL1 | NA | CX3CL1 Entrez, Source | chemokine (C-X3-C motif) ligand 1 | 1151 | 2.210 | 0.3487 | Yes |
| 19 | C11orf41 | NA | C11ORF41 Entrez, Source | chromosome 11 open reading frame 41 | 1164 | 2.200 | 0.3659 | Yes |
| 20 | TIMP4 | NA | TIMP4 Entrez, Source | TIMP metallopeptidase inhibitor 4 | 1166 | 2.198 | 0.3835 | Yes |
| 21 | NBEA | NA | NBEA Entrez, Source | neurobeachin | 1440 | 2.011 | 0.3896 | Yes |
| 22 | FABP3 | NA | FABP3 Entrez, Source | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | 1573 | 1.939 | 0.4003 | Yes |
| 23 | TGFBR1 | NA | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 1717 | 1.864 | 0.4100 | Yes |
| 24 | ETV5 | NA | ETV5 Entrez, Source | ets variant gene 5 (ets-related molecule) | 1991 | 1.731 | 0.4138 | Yes |
| 25 | NXPH3 | NA | NXPH3 Entrez, Source | neurexophilin 3 | 2184 | 1.640 | 0.4199 | Yes |
| 26 | DNM1 | NA | DNM1 Entrez, Source | dynamin 1 | 2462 | 1.521 | 0.4219 | Yes |
| 27 | PDK4 | NA | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 2577 | 1.470 | 0.4295 | Yes |
| 28 | CAMK2B | NA | CAMK2B Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | 2960 | 1.324 | 0.4261 | Yes |
| 29 | TUBA8 | NA | TUBA8 Entrez, Source | tubulin, alpha 8 | 2965 | 1.320 | 0.4366 | Yes |
| 30 | KHDC1 | NA | 3744 | 1.070 | 0.4165 | No | ||
| 31 | FOXF2 | NA | FOXF2 Entrez, Source | forkhead box F2 | 3826 | 1.041 | 0.4219 | No |
| 32 | MLXIPL | NA | MLXIPL Entrez, Source | MLX interacting protein-like | 3994 | 0.988 | 0.4237 | No |
| 33 | YPEL1 | NA | YPEL1 Entrez, Source | yippee-like 1 (Drosophila) | 4152 | 0.945 | 0.4255 | No |
| 34 | LIMD2 | NA | LIMD2 Entrez, Source | LIM domain containing 2 | 4411 | 0.881 | 0.4231 | No |
| 35 | INSM1 | NA | INSM1 Entrez, Source | insulinoma-associated 1 | 4483 | 0.865 | 0.4274 | No |
| 36 | GSTCD | NA | GSTCD Entrez, Source | glutathione S-transferase, C-terminal domain containing | 5221 | 0.689 | 0.4058 | No |
| 37 | CEL | NA | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 5598 | 0.597 | 0.3968 | No |
| 38 | ARHGAP24 | NA | ARHGAP24 Entrez, Source | Rho GTPase activating protein 24 | 5839 | 0.555 | 0.3924 | No |
| 39 | NOL4 | NA | NOL4 Entrez, Source | nucleolar protein 4 | 5940 | 0.539 | 0.3931 | No |
| 40 | LRCH1 | NA | LRCH1 Entrez, Source | leucine-rich repeats and calponin homology (CH) domain containing 1 | 7246 | 0.371 | 0.3480 | No |
| 41 | ABHD8 | NA | ABHD8 Entrez, Source | abhydrolase domain containing 8 | 7251 | 0.371 | 0.3509 | No |
| 42 | C5orf42 | NA | 7257 | 0.370 | 0.3537 | No | ||
| 43 | TSSK2 | NA | TSSK2 Entrez, Source | testis-specific serine kinase 2 | 7619 | 0.334 | 0.3431 | No |
| 44 | CD79A | NA | CD79A Entrez, Source | CD79a molecule, immunoglobulin-associated alpha | 7709 | 0.325 | 0.3424 | No |
| 45 | EMID2 | NA | EMID2 Entrez, Source | EMI domain containing 2 | 8068 | 0.295 | 0.3316 | No |
| 46 | CBX4 | NA | CBX4 Entrez, Source | chromobox homolog 4 (Pc class homolog, Drosophila) | 8357 | 0.272 | 0.3232 | No |
| 47 | HABP2 | NA | HABP2 Entrez, Source | hyaluronan binding protein 2 | 8451 | 0.266 | 0.3219 | No |
| 48 | KRT36 | NA | KRT36 Entrez, Source | keratin 36 | 8455 | 0.265 | 0.3239 | No |
| 49 | CHRNA3 | NA | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 9167 | 0.221 | 0.2995 | No |
| 50 | MYO7B | NA | MYO7B Entrez, Source | myosin VIIB | 9594 | 0.198 | 0.2855 | No |
| 51 | LIN7B | NA | LIN7B Entrez, Source | lin-7 homolog B (C. elegans) | 9837 | 0.186 | 0.2781 | No |
| 52 | PLCH2 | NA | PLCH2 Entrez, Source | phospholipase C, eta 2 | 9884 | 0.184 | 0.2778 | No |
| 53 | TNNI1 | NA | TNNI1 Entrez, Source | troponin I type 1 (skeletal, slow) | 9982 | 0.179 | 0.2757 | No |
| 54 | ATXN3L | NA | ATXN3L Entrez, Source | ataxin 3-like | 10031 | 0.177 | 0.2754 | No |
| 55 | CNTN5 | NA | CNTN5 Entrez, Source | contactin 5 | 10065 | 0.175 | 0.2756 | No |
| 56 | TRIM31 | NA | TRIM31 Entrez, Source | tripartite motif-containing 31 | 10150 | 0.172 | 0.2739 | No |
| 57 | IL1RL2 | NA | IL1RL2 Entrez, Source | interleukin 1 receptor-like 2 | 10200 | 0.170 | 0.2734 | No |
| 58 | IFNA7 | NA | IFNA7 Entrez, Source | interferon, alpha 7 | 10256 | 0.167 | 0.2727 | No |
| 59 | CNGB3 | NA | CNGB3 Entrez, Source | cyclic nucleotide gated channel beta 3 | 10413 | 0.160 | 0.2683 | No |
| 60 | CR2 | NA | CR2 Entrez, Source | complement component (3d/Epstein Barr virus) receptor 2 | 10732 | 0.145 | 0.2577 | No |
| 61 | CFHR2 | NA | CFHR2 Entrez, Source | complement factor H-related 2 | 10851 | 0.139 | 0.2545 | No |
| 62 | SLCO1C1 | NA | SLCO1C1 Entrez, Source | solute carrier organic anion transporter family, member 1C1 | 10931 | 0.136 | 0.2527 | No |
| 63 | PPYR1 | NA | PPYR1 Entrez, Source | pancreatic polypeptide receptor 1 | 11079 | 0.128 | 0.2483 | No |
| 64 | CRISP1 | NA | CRISP1 Entrez, Source | cysteine-rich secretory protein 1 | 11103 | 0.127 | 0.2485 | No |
| 65 | TEX12 | NA | TEX12 Entrez, Source | testis expressed sequence 12 | 11226 | 0.122 | 0.2450 | No |
| 66 | FGF22 | NA | FGF22 Entrez, Source | fibroblast growth factor 22 | 11318 | 0.117 | 0.2426 | No |
| 67 | FGA | NA | FGA Entrez, Source | fibrinogen alpha chain | 11584 | 0.107 | 0.2337 | No |
| 68 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 11947 | 0.092 | 0.2211 | No |
| 69 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 12340 | 0.077 | 0.2073 | No |
| 70 | SYT5 | NA | SYT5 Entrez, Source | synaptotagmin V | 12396 | 0.075 | 0.2059 | No |
| 71 | IL10RA | NA | IL10RA Entrez, Source | interleukin 10 receptor, alpha | 12399 | 0.075 | 0.2064 | No |
| 72 | LAIR2 | NA | LAIR2 Entrez, Source | leukocyte-associated immunoglobulin-like receptor 2 | 12568 | 0.069 | 0.2008 | No |
| 73 | LILRA6 | NA | LILRA6 Entrez, Source | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 12898 | 0.057 | 0.1892 | No |
| 74 | PCDHA2 | NA | PCDHA2 Entrez, Source | protocadherin alpha 2 | 13861 | 0.020 | 0.1540 | No |
| 75 | NPY6R | NA | NPY6R Entrez, Source | neuropeptide Y receptor Y6 (pseudogene) | 13898 | 0.018 | 0.1528 | No |
| 76 | C6orf103 | NA | C6ORF103 Entrez, Source | chromosome 6 open reading frame 103 | 14602 | -0.006 | 0.1270 | No |
| 77 | ANP32C | NA | ANP32C Entrez, Source | acidic (leucine-rich) nuclear phosphoprotein 32 family, member C | 15066 | -0.024 | 0.1102 | No |
| 78 | AHSG | NA | AHSG Entrez, Source | alpha-2-HS-glycoprotein | 15122 | -0.026 | 0.1084 | No |
| 79 | FGF21 | NA | FGF21 Entrez, Source | fibroblast growth factor 21 | 15291 | -0.033 | 0.1024 | No |
| 80 | ANKRD34C | NA | 15475 | -0.040 | 0.0960 | No | ||
| 81 | AICDA | NA | AICDA Entrez, Source | activation-induced cytidine deaminase | 15595 | -0.044 | 0.0920 | No |
| 82 | RGS13 | NA | RGS13 Entrez, Source | regulator of G-protein signalling 13 | 16181 | -0.068 | 0.0710 | No |
| 83 | PIGR | NA | PIGR Entrez, Source | polymeric immunoglobulin receptor | 16253 | -0.072 | 0.0690 | No |
| 84 | RAB40C | NA | RAB40C Entrez, Source | RAB40C, member RAS oncogene family | 16478 | -0.080 | 0.0614 | No |
| 85 | CRISP2 | NA | CRISP2 Entrez, Source | cysteine-rich secretory protein 2 | 16677 | -0.088 | 0.0548 | No |
| 86 | RARRES2 | NA | RARRES2 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 2 | 16728 | -0.090 | 0.0537 | No |
| 87 | DHRS9 | NA | DHRS9 Entrez, Source | dehydrogenase/reductase (SDR family) member 9 | 16733 | -0.090 | 0.0543 | No |
| 88 | PTPN7 | NA | PTPN7 Entrez, Source | protein tyrosine phosphatase, non-receptor type 7 | 16799 | -0.093 | 0.0527 | No |
| 89 | APOH | NA | APOH Entrez, Source | apolipoprotein H (beta-2-glycoprotein I) | 16916 | -0.098 | 0.0492 | No |
| 90 | SLC10A2 | NA | SLC10A2 Entrez, Source | solute carrier family 10 (sodium/bile acid cotransporter family), member 2 | 17130 | -0.107 | 0.0422 | No |
| 91 | KLRG1 | NA | KLRG1 Entrez, Source | killer cell lectin-like receptor subfamily G, member 1 | 17150 | -0.108 | 0.0424 | No |
| 92 | SV2C | NA | SV2C Entrez, Source | synaptic vesicle glycoprotein 2C | 17263 | -0.113 | 0.0392 | No |
| 93 | SYNPO2 | NA | SYNPO2 Entrez, Source | synaptopodin 2 | 17274 | -0.113 | 0.0397 | No |
| 94 | FSD1 | NA | FSD1 Entrez, Source | fibronectin type III and SPRY domain containing 1 | 17349 | -0.117 | 0.0379 | No |
| 95 | FOXH1 | NA | FOXH1 Entrez, Source | forkhead box H1 | 17430 | -0.121 | 0.0359 | No |
| 96 | BANK1 | NA | BANK1 Entrez, Source | B-cell scaffold protein with ankyrin repeats 1 | 17554 | -0.127 | 0.0324 | No |
| 97 | MYOC | NA | MYOC Entrez, Source | myocilin, trabecular meshwork inducible glucocorticoid response | 17576 | -0.128 | 0.0327 | No |
| 98 | SLC7A4 | NA | SLC7A4 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 | 17845 | -0.144 | 0.0240 | No |
| 99 | OR10J1 | NA | OR10J1 Entrez, Source | olfactory receptor, family 10, subfamily J, member 1 | 17998 | -0.153 | 0.0196 | No |
| 100 | LAPTM5 | NA | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 18352 | -0.175 | 0.0081 | No |
| 101 | MAGEB3 | NA | MAGEB3 Entrez, Source | melanoma antigen family B, 3 | 18357 | -0.175 | 0.0093 | No |
| 102 | MAP4K1 | NA | MAP4K1 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 1 | 18558 | -0.189 | 0.0035 | No |
| 103 | LRRC15 | NA | LRRC15 Entrez, Source | leucine rich repeat containing 15 | 18945 | -0.222 | -0.0089 | No |
| 104 | TLR4 | NA | TLR4 Entrez, Source | toll-like receptor 4 | 19079 | -0.233 | -0.0120 | No |
| 105 | PADI3 | NA | PADI3 Entrez, Source | peptidyl arginine deiminase, type III | 19240 | -0.247 | -0.0159 | No |
| 106 | APOBEC3G | NA | APOBEC3G Entrez, Source | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 19256 | -0.248 | -0.0144 | No |
| 107 | C2orf67 | NA | 19582 | -0.278 | -0.0241 | No | ||
| 108 | ZSWIM1 | NA | ZSWIM1 Entrez, Source | zinc finger, SWIM-type containing 1 | 19718 | -0.291 | -0.0268 | No |
| 109 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 20150 | -0.337 | -0.0399 | No |
| 110 | HAL | NA | HAL Entrez, Source | histidine ammonia-lyase | 20938 | -0.443 | -0.0653 | No |
| 111 | PLLP | NA | PLLP Entrez, Source | plasma membrane proteolipid (plasmolipin) | 21124 | -0.471 | -0.0683 | No |
| 112 | CADPS2 | NA | CADPS2 Entrez, Source | Ca2+-dependent activator protein for secretion 2 | 21163 | -0.475 | -0.0659 | No |
| 113 | CYP2R1 | NA | CYP2R1 Entrez, Source | cytochrome P450, family 2, subfamily R, polypeptide 1 | 21549 | -0.543 | -0.0757 | No |
| 114 | STRN | NA | STRN Entrez, Source | striatin, calmodulin binding protein | 22233 | -0.672 | -0.0954 | No |
| 115 | MMP17 | NA | MMP17 Entrez, Source | matrix metallopeptidase 17 (membrane-inserted) | 22347 | -0.696 | -0.0940 | No |
| 116 | MYRIP | NA | MYRIP Entrez, Source | myosin VIIA and Rab interacting protein | 22664 | -0.767 | -0.0995 | No |
| 117 | C17orf53 | NA | C17ORF53 Entrez, Source | chromosome 17 open reading frame 53 | 22874 | -0.812 | -0.1007 | No |
| 118 | GLB1L2 | NA | 23138 | -0.866 | -0.1034 | No | ||
| 119 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 23140 | -0.867 | -0.0965 | No |
| 120 | TWIST1 | NA | TWIST1 Entrez, Source | twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) | 24147 | -1.134 | -0.1244 | No |
| 121 | TPK1 | NA | TPK1 Entrez, Source | thiamin pyrophosphokinase 1 | 24209 | -1.150 | -0.1174 | No |
| 122 | KREMEN2 | NA | KREMEN2 Entrez, Source | kringle containing transmembrane protein 2 | 24397 | -1.211 | -0.1146 | No |
| 123 | THSD4 | NA | THSD4 Entrez, Source | thrombospondin, type I, domain containing 4 | 24429 | -1.221 | -0.1059 | No |
| 124 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 24721 | -1.317 | -0.1060 | No |
| 125 | NR4A3 | NA | NR4A3 Entrez, Source | nuclear receptor subfamily 4, group A, member 3 | 24787 | -1.341 | -0.0977 | No |
| 126 | ADM2 | NA | ADM2 Entrez, Source | adrenomedullin 2 | 24818 | -1.350 | -0.0880 | No |
| 127 | KRT8P12 | NA | 25992 | -1.912 | -0.1158 | No | ||
| 128 | ADRA1B | NA | ADRA1B Entrez, Source | adrenergic, alpha-1B-, receptor | 26004 | -1.917 | -0.1008 | No |
| 129 | CFH | NA | CFH Entrez, Source | complement factor H | 26651 | -2.446 | -0.1049 | No |
| 130 | OR7E24 | NA | OR7E24 Entrez, Source | olfactory receptor, family 7, subfamily E, member 24 | 27026 | -3.121 | -0.0937 | No |
| 131 | FAM155B | NA | 27228 | -3.985 | -0.0691 | No | ||
| 132 | VEGFC | NA | VEGFC Entrez, Source | vascular endothelial growth factor C | 27284 | -4.454 | -0.0354 | No |
| 133 | OPLAH | NA | OPLAH Entrez, Source | 5-oxoprolinase (ATP-hydrolysing) | 27305 | -4.617 | 0.0009 | No |
