Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | P53_DN.V2_UP |
| Enrichment Score (ES) | -0.34388793 |
| Normalized Enrichment Score (NES) | -1.6306202 |
| Nominal p-value | 0.00811359 |
| FDR q-value | 0.07053082 |
| FWER p-Value | 0.079 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PTX3 | NA | PTX3 Entrez, Source | pentraxin-related gene, rapidly induced by IL-1 beta | 227 | 3.226 | 0.0226 | No |
| 2 | CDH4 | NA | CDH4 Entrez, Source | cadherin 4, type 1, R-cadherin (retinal) | 524 | 2.756 | 0.0382 | No |
| 3 | ANGPTL4 | NA | ANGPTL4 Entrez, Source | angiopoietin-like 4 | 866 | 2.417 | 0.0489 | No |
| 4 | CLEC1A | NA | CLEC1A Entrez, Source | C-type lectin domain family 1, member A | 872 | 2.412 | 0.0718 | No |
| 5 | CHST8 | NA | CHST8 Entrez, Source | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | 1022 | 2.304 | 0.0885 | No |
| 6 | RFX2 | NA | RFX2 Entrez, Source | regulatory factor X, 2 (influences HLA class II expression) | 1061 | 2.271 | 0.1089 | No |
| 7 | SLC16A4 | NA | SLC16A4 Entrez, Source | solute carrier family 16, member 4 (monocarboxylic acid transporter 5) | 1412 | 2.026 | 0.1155 | No |
| 8 | RND2 | NA | RND2 Entrez, Source | Rho family GTPase 2 | 1646 | 1.897 | 0.1251 | No |
| 9 | BAX | NA | BAX Entrez, Source | BCL2-associated X protein | 1823 | 1.810 | 0.1360 | No |
| 10 | ETV5 | NA | ETV5 Entrez, Source | ets variant gene 5 (ets-related molecule) | 1991 | 1.731 | 0.1465 | No |
| 11 | NTRK3 | NA | NTRK3 Entrez, Source | neurotrophic tyrosine kinase, receptor, type 3 | 1993 | 1.729 | 0.1630 | No |
| 12 | PCDH1 | NA | PCDH1 Entrez, Source | protocadherin 1 (cadherin-like 1) | 2116 | 1.669 | 0.1746 | No |
| 13 | SLC15A2 | NA | SLC15A2 Entrez, Source | solute carrier family 15 (H+/peptide transporter), member 2 | 2398 | 1.547 | 0.1791 | No |
| 14 | RGR | NA | RGR Entrez, Source | retinal G protein coupled receptor | 2537 | 1.487 | 0.1883 | No |
| 15 | SLC38A3 | NA | SLC38A3 Entrez, Source | solute carrier family 38, member 3 | 2786 | 1.390 | 0.1925 | No |
| 16 | DPF1 | NA | DPF1 Entrez, Source | D4, zinc and double PHD fingers family 1 | 3154 | 1.257 | 0.1911 | No |
| 17 | PTK2B | NA | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 3842 | 1.037 | 0.1758 | No |
| 18 | WNT3 | NA | WNT3 Entrez, Source | wingless-type MMTV integration site family, member 3 | 4053 | 0.971 | 0.1774 | No |
| 19 | INPP5D | NA | INPP5D Entrez, Source | inositol polyphosphate-5-phosphatase, 145kDa | 5714 | 0.576 | 0.1218 | No |
| 20 | MT1G | NA | MT1G Entrez, Source | metallothionein 1G | 6000 | 0.526 | 0.1164 | No |
| 21 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 6294 | 0.482 | 0.1102 | No |
| 22 | GSC2 | NA | 6448 | 0.458 | 0.1090 | No | ||
| 23 | SLC4A10 | NA | SLC4A10 Entrez, Source | solute carrier family 4, sodium bicarbonate transporter-like, member 10 | 6451 | 0.458 | 0.1133 | No |
| 24 | CHRNA10 | NA | CHRNA10 Entrez, Source | cholinergic receptor, nicotinic, alpha 10 | 6477 | 0.455 | 0.1168 | No |
| 25 | PRDM11 | NA | PRDM11 Entrez, Source | PR domain containing 11 | 6686 | 0.430 | 0.1133 | No |
| 26 | NFIX | NA | NFIX Entrez, Source | nuclear factor I/X (CCAAT-binding transcription factor) | 6730 | 0.425 | 0.1158 | No |
| 27 | APOL3 | NA | APOL3 Entrez, Source | apolipoprotein L, 3 | 7159 | 0.381 | 0.1037 | No |
| 28 | KRT31 | NA | KRT31 Entrez, Source | keratin 31 | 7406 | 0.354 | 0.0980 | No |
| 29 | SLA | NA | SLA Entrez, Source | Src-like-adaptor | 7429 | 0.351 | 0.1006 | No |
| 30 | CYP2A13 | NA | CYP2A13 Entrez, Source | cytochrome P450, family 2, subfamily A, polypeptide 13 | 7722 | 0.323 | 0.0929 | No |
| 31 | RNF39 | NA | RNF39 Entrez, Source | ring finger protein 39 | 8210 | 0.284 | 0.0778 | No |
| 32 | PRTN3 | NA | PRTN3 Entrez, Source | proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) | 8235 | 0.283 | 0.0796 | No |
| 33 | CYP2D6 | NA | CYP2D6 Entrez, Source | cytochrome P450, family 2, subfamily D, polypeptide 6 | 8264 | 0.281 | 0.0812 | No |
| 34 | HIST1H1T | NA | HIST1H1T Entrez, Source | histone cluster 1, H1t | 8821 | 0.240 | 0.0631 | No |
| 35 | IKZF1 | NA | IKZF1 Entrez, Source | IKAROS family zinc finger 1 (Ikaros) | 9279 | 0.215 | 0.0484 | No |
| 36 | H6PD | NA | H6PD Entrez, Source | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | 9560 | 0.200 | 0.0400 | No |
| 37 | KRT14 | NA | KRT14 Entrez, Source | keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) | 9655 | 0.195 | 0.0384 | No |
| 38 | MMP13 | NA | MMP13 Entrez, Source | matrix metallopeptidase 13 (collagenase 3) | 10480 | 0.157 | 0.0096 | No |
| 39 | TNR | NA | TNR Entrez, Source | tenascin R (restrictin, janusin) | 10594 | 0.152 | 0.0069 | No |
| 40 | RORC | NA | RORC Entrez, Source | RAR-related orphan receptor C | 10635 | 0.150 | 0.0068 | No |
| 41 | PF4V1 | NA | PF4V1 Entrez, Source | platelet factor 4 variant 1 | 10717 | 0.145 | 0.0053 | No |
| 42 | IL1RAPL1 | NA | IL1RAPL1 Entrez, Source | interleukin 1 receptor accessory protein-like 1 | 10782 | 0.142 | 0.0043 | No |
| 43 | TUBB1 | NA | TUBB1 Entrez, Source | tubulin, beta 1 | 10788 | 0.142 | 0.0055 | No |
| 44 | CCL4 | NA | CCL4 Entrez, Source | chemokine (C-C motif) ligand 4 | 10911 | 0.137 | 0.0023 | No |
| 45 | AMELX | NA | AMELX Entrez, Source | amelogenin (amelogenesis imperfecta 1, X-linked) | 10955 | 0.135 | 0.0020 | No |
| 46 | PRRG3 | NA | PRRG3 Entrez, Source | proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) | 11108 | 0.127 | -0.0024 | No |
| 47 | MOG | NA | MOG Entrez, Source | myelin oligodendrocyte glycoprotein | 11147 | 0.125 | -0.0026 | No |
| 48 | LRRC32 | NA | LRRC32 Entrez, Source | leucine rich repeat containing 32 | 11303 | 0.118 | -0.0071 | No |
| 49 | EVX1 | NA | EVX1 Entrez, Source | eve, even-skipped homeobox homolog 1 (Drosophila) | 11311 | 0.117 | -0.0063 | No |
| 50 | FGF22 | NA | FGF22 Entrez, Source | fibroblast growth factor 22 | 11318 | 0.117 | -0.0054 | No |
| 51 | C4BPA | NA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 11406 | 0.113 | -0.0075 | No |
| 52 | ADAM12 | NA | ADAM12 Entrez, Source | ADAM metallopeptidase domain 12 (meltrin alpha) | 11530 | 0.109 | -0.0110 | No |
| 53 | MPZ | NA | MPZ Entrez, Source | myelin protein zero (Charcot-Marie-Tooth neuropathy 1B) | 12065 | 0.088 | -0.0298 | No |
| 54 | KCNK3 | NA | KCNK3 Entrez, Source | potassium channel, subfamily K, member 3 | 12068 | 0.088 | -0.0290 | No |
| 55 | CXCL6 | NA | CXCL6 Entrez, Source | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | 12156 | 0.084 | -0.0314 | No |
| 56 | HIST1H2AB | NA | HIST1H2AB Entrez, Source | histone cluster 1, H2ab | 12216 | 0.082 | -0.0328 | No |
| 57 | GUCY2D | NA | GUCY2D Entrez, Source | guanylate cyclase 2D, membrane (retina-specific) | 12229 | 0.081 | -0.0324 | No |
| 58 | LGSN | NA | 12338 | 0.077 | -0.0357 | No | ||
| 59 | CCL20 | NA | CCL20 Entrez, Source | chemokine (C-C motif) ligand 20 | 12374 | 0.076 | -0.0362 | No |
| 60 | NCKAP1L | NA | NCKAP1L Entrez, Source | NCK-associated protein 1-like | 12438 | 0.073 | -0.0378 | No |
| 61 | MMP3 | NA | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 12473 | 0.072 | -0.0384 | No |
| 62 | BPI | NA | BPI Entrez, Source | bactericidal/permeability-increasing protein | 12479 | 0.072 | -0.0379 | No |
| 63 | ANGPTL3 | NA | ANGPTL3 Entrez, Source | angiopoietin-like 3 | 12616 | 0.067 | -0.0422 | No |
| 64 | ALOX5AP | NA | ALOX5AP Entrez, Source | arachidonate 5-lipoxygenase-activating protein | 12698 | 0.064 | -0.0446 | No |
| 65 | CYP17A1 | NA | CYP17A1 Entrez, Source | cytochrome P450, family 17, subfamily A, polypeptide 1 | 12871 | 0.058 | -0.0504 | No |
| 66 | IL1RN | NA | IL1RN Entrez, Source | interleukin 1 receptor antagonist | 13063 | 0.050 | -0.0569 | No |
| 67 | SPRR1B | NA | SPRR1B Entrez, Source | small proline-rich protein 1B (cornifin) | 13126 | 0.048 | -0.0587 | No |
| 68 | SYN1 | NA | SYN1 Entrez, Source | synapsin I | 13172 | 0.046 | -0.0599 | No |
| 69 | OSGIN1 | NA | OSGIN1 Entrez, Source | oxidative stress induced growth inhibitor 1 | 13198 | 0.045 | -0.0604 | No |
| 70 | TNNI3K | NA | TNNI3K Entrez, Source | TNNI3 interacting kinase | 13537 | 0.032 | -0.0726 | No |
| 71 | CACNG2 | NA | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 13702 | 0.026 | -0.0783 | No |
| 72 | AVPR2 | NA | AVPR2 Entrez, Source | arginine vasopressin receptor 2 (nephrogenic diabetes insipidus) | 13934 | 0.017 | -0.0867 | No |
| 73 | CYP2C8 | NA | CYP2C8 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 8 | 14188 | 0.009 | -0.0959 | No |
| 74 | HS3ST2 | NA | HS3ST2 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 | 14265 | 0.005 | -0.0986 | No |
| 75 | HAO1 | NA | HAO1 Entrez, Source | hydroxyacid oxidase (glycolate oxidase) 1 | 14341 | 0.003 | -0.1014 | No |
| 76 | CTLA4 | NA | CTLA4 Entrez, Source | cytotoxic T-lymphocyte-associated protein 4 | 14412 | 0.001 | -0.1039 | No |
| 77 | MAGEC2 | NA | MAGEC2 Entrez, Source | melanoma antigen family C, 2 | 14511 | -0.003 | -0.1075 | No |
| 78 | CH25H | NA | CH25H Entrez, Source | cholesterol 25-hydroxylase | 14556 | -0.004 | -0.1091 | No |
| 79 | GYPB | NA | GYPB Entrez, Source | glycophorin B (MNS blood group) | 14697 | -0.009 | -0.1141 | No |
| 80 | DPYS | NA | DPYS Entrez, Source | dihydropyrimidinase | 14745 | -0.011 | -0.1158 | No |
| 81 | CD5L | NA | CD5L Entrez, Source | CD5 molecule-like | 15045 | -0.023 | -0.1265 | No |
| 82 | KCNMB1 | NA | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 15112 | -0.026 | -0.1287 | No |
| 83 | LALBA | NA | LALBA Entrez, Source | lactalbumin, alpha- | 15155 | -0.027 | -0.1300 | No |
| 84 | CD69 | NA | CD69 Entrez, Source | CD69 molecule | 15159 | -0.028 | -0.1299 | No |
| 85 | POU2AF1 | NA | POU2AF1 Entrez, Source | POU domain, class 2, associating factor 1 | 15273 | -0.032 | -0.1337 | No |
| 86 | CEACAM5 | NA | CEACAM5 Entrez, Source | carcinoembryonic antigen-related cell adhesion molecule 5 | 15452 | -0.039 | -0.1399 | No |
| 87 | FCRL2 | NA | FCRL2 Entrez, Source | Fc receptor-like 2 | 15522 | -0.042 | -0.1420 | No |
| 88 | IL8 | NA | IL8 Entrez, Source | interleukin 8 | 15907 | -0.056 | -0.1556 | No |
| 89 | GPA33 | NA | GPA33 Entrez, Source | glycoprotein A33 (transmembrane) | 16684 | -0.088 | -0.1833 | No |
| 90 | PKD2L1 | NA | PKD2L1 Entrez, Source | polycystic kidney disease 2-like 1 | 16713 | -0.090 | -0.1835 | No |
| 91 | PCDHA6 | NA | PCDHA6 Entrez, Source | protocadherin alpha 6 | 16719 | -0.090 | -0.1828 | No |
| 92 | CA3 | NA | CA3 Entrez, Source | carbonic anhydrase III, muscle specific | 16830 | -0.094 | -0.1859 | No |
| 93 | ITM2A | NA | ITM2A Entrez, Source | integral membrane protein 2A | 17191 | -0.110 | -0.1981 | No |
| 94 | CXCL12 | NA | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 17216 | -0.111 | -0.1979 | No |
| 95 | SPRR2C | NA | SPRR2C Entrez, Source | small proline-rich protein 2C | 17290 | -0.114 | -0.1995 | No |
| 96 | XAF1 | NA | 17404 | -0.120 | -0.2025 | No | ||
| 97 | RHD | NA | RHD Entrez, Source | Rh blood group, D antigen | 17411 | -0.120 | -0.2016 | No |
| 98 | INSL3 | NA | INSL3 Entrez, Source | insulin-like 3 (Leydig cell) | 17662 | -0.132 | -0.2095 | No |
| 99 | PDC | NA | PDC Entrez, Source | phosducin | 17997 | -0.153 | -0.2203 | No |
| 100 | SPINK1 | NA | SPINK1 Entrez, Source | serine peptidase inhibitor, Kazal type 1 | 18001 | -0.153 | -0.2190 | No |
| 101 | PYY | NA | PYY Entrez, Source | peptide YY | 18260 | -0.169 | -0.2269 | No |
| 102 | INSL4 | NA | INSL4 Entrez, Source | insulin-like 4 (placenta) | 18570 | -0.190 | -0.2364 | No |
| 103 | PRKCE | NA | PRKCE Entrez, Source | protein kinase C, epsilon | 18589 | -0.192 | -0.2352 | No |
| 104 | POU6F1 | NA | POU6F1 Entrez, Source | POU domain, class 6, transcription factor 1 | 18854 | -0.214 | -0.2429 | No |
| 105 | HTR1E | NA | HTR1E Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 1E | 19108 | -0.236 | -0.2499 | No |
| 106 | RFPL2 | NA | RFPL2 Entrez, Source | ret finger protein-like 2 | 19344 | -0.254 | -0.2561 | No |
| 107 | BFSP2 | NA | BFSP2 Entrez, Source | beaded filament structural protein 2, phakinin | 19633 | -0.284 | -0.2640 | No |
| 108 | GP5 | NA | GP5 Entrez, Source | glycoprotein V (platelet) | 19695 | -0.288 | -0.2635 | No |
| 109 | FPR3 | NA | 20316 | -0.358 | -0.2828 | No | ||
| 110 | BARX2 | NA | BARX2 Entrez, Source | BarH-like homeobox 2 | 20487 | -0.379 | -0.2854 | No |
| 111 | P2RY11 | NA | P2RY11 Entrez, Source | purinergic receptor P2Y, G-protein coupled, 11 | 20648 | -0.399 | -0.2875 | No |
| 112 | RQCD1 | NA | RQCD1 Entrez, Source | RCD1 required for cell differentiation1 homolog (S. pombe) | 20810 | -0.423 | -0.2894 | No |
| 113 | ANXA10 | NA | ANXA10 Entrez, Source | annexin A10 | 20884 | -0.436 | -0.2879 | No |
| 114 | TNFRSF9 | NA | TNFRSF9 Entrez, Source | tumor necrosis factor receptor superfamily, member 9 | 21018 | -0.456 | -0.2884 | No |
| 115 | SARDH | NA | SARDH Entrez, Source | sarcosine dehydrogenase | 21033 | -0.458 | -0.2845 | No |
| 116 | FOSL2 | NA | FOSL2 Entrez, Source | FOS-like antigen 2 | 21209 | -0.482 | -0.2863 | No |
| 117 | OSGIN2 | NA | OSGIN2 Entrez, Source | oxidative stress induced growth inhibitor family member 2 | 21297 | -0.496 | -0.2847 | No |
| 118 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 21656 | -0.561 | -0.2925 | No |
| 119 | PPEF1 | NA | PPEF1 Entrez, Source | protein phosphatase, EF-hand calcium binding domain 1 | 21815 | -0.595 | -0.2926 | No |
| 120 | TFAP4 | NA | TFAP4 Entrez, Source | transcription factor AP-4 (activating enhancer binding protein 4) | 22080 | -0.644 | -0.2962 | No |
| 121 | MMP17 | NA | MMP17 Entrez, Source | matrix metallopeptidase 17 (membrane-inserted) | 22347 | -0.696 | -0.2993 | No |
| 122 | CD83 | NA | CD83 Entrez, Source | CD83 molecule | 22644 | -0.763 | -0.3028 | No |
| 123 | ATP12A | NA | ATP12A Entrez, Source | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | 22658 | -0.766 | -0.2959 | No |
| 124 | GALK1 | NA | GALK1 Entrez, Source | galactokinase 1 | 22776 | -0.790 | -0.2927 | No |
| 125 | TNFAIP3 | NA | TNFAIP3 Entrez, Source | tumor necrosis factor, alpha-induced protein 3 | 23231 | -0.887 | -0.3008 | No |
| 126 | RELB | NA | RELB Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian) | 24402 | -1.211 | -0.3323 | Yes |
| 127 | TDRKH | NA | TDRKH Entrez, Source | tudor and KH domain containing | 24623 | -1.283 | -0.3280 | Yes |
| 128 | NTSR1 | NA | NTSR1 Entrez, Source | neurotensin receptor 1 (high affinity) | 24807 | -1.347 | -0.3218 | Yes |
| 129 | CXCL2 | NA | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 24873 | -1.368 | -0.3111 | Yes |
| 130 | P2RY6 | NA | P2RY6 Entrez, Source | pyrimidinergic receptor P2Y, G-protein coupled, 6 | 25156 | -1.486 | -0.3072 | Yes |
| 131 | NF1 | NA | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 25328 | -1.560 | -0.2985 | Yes |
| 132 | CD68 | NA | CD68 Entrez, Source | CD68 molecule | 25551 | -1.665 | -0.2907 | Yes |
| 133 | FZD9 | NA | FZD9 Entrez, Source | frizzled homolog 9 (Drosophila) | 25610 | -1.692 | -0.2766 | Yes |
| 134 | CXCL1 | NA | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 25823 | -1.806 | -0.2670 | Yes |
| 135 | TPTE | NA | TPTE Entrez, Source | transmembrane phosphatase with tensin homology | 26208 | -2.063 | -0.2614 | Yes |
| 136 | EML3 | NA | EML3 Entrez, Source | echinoderm microtubule associated protein like 3 | 26296 | -2.126 | -0.2442 | Yes |
| 137 | DLX6 | NA | DLX6 Entrez, Source | distal-less homeobox 6 | 26641 | -2.435 | -0.2334 | Yes |
| 138 | CLCF1 | NA | CLCF1 Entrez, Source | cardiotrophin-like cytokine factor 1 | 26666 | -2.460 | -0.2107 | Yes |
| 139 | SDC4 | NA | SDC4 Entrez, Source | syndecan 4 (amphiglycan, ryudocan) | 26750 | -2.560 | -0.1892 | Yes |
| 140 | FOXL2 | NA | FOXL2 Entrez, Source | forkhead box L2 | 26796 | -2.638 | -0.1655 | Yes |
| 141 | EVI2A | NA | EVI2A Entrez, Source | ecotropic viral integration site 2A | 27034 | -3.146 | -0.1440 | Yes |
| 142 | IER3 | NA | IER3 Entrez, Source | immediate early response 3 | 27068 | -3.228 | -0.1142 | Yes |
| 143 | CXCL5 | NA | CXCL5 Entrez, Source | chemokine (C-X-C motif) ligand 5 | 27183 | -3.696 | -0.0829 | Yes |
| 144 | ME3 | NA | ME3 Entrez, Source | malic enzyme 3, NADP(+)-dependent, mitochondrial | 27298 | -4.582 | -0.0432 | Yes |
| 145 | RIPK4 | NA | RIPK4 Entrez, Source | receptor-interacting serine-threonine kinase 4 | 27303 | -4.610 | 0.0010 | Yes |
