Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_mean_normalized_with_dChip_geneAvg_Mar1014_PNs.mainSample.cls #wt_versus_radiation.mainSample.cls #wt_versus_radiation_repos |
| Phenotype | mainSample.cls#wt_versus_radiation_repos |
| Upregulated in class | 2 |
| GeneSet | SIRNA_EIF4GI_DN |
| Enrichment Score (ES) | -0.3335973 |
| Normalized Enrichment Score (NES) | -1.2880213 |
| Nominal p-value | 0.055776894 |
| FDR q-value | 0.25556153 |
| FWER p-Value | 0.782 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PMP22 | NA | PMP22 Entrez, Source | peripheral myelin protein 22 | 41 | 3.713 | 0.0365 | No |
| 2 | CDKN2C | NA | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 93 | 3.507 | 0.0705 | No |
| 3 | CDH11 | NA | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 141 | 3.374 | 0.1034 | No |
| 4 | CYTL1 | NA | CYTL1 Entrez, Source | cytokine-like 1 | 179 | 3.299 | 0.1358 | No |
| 5 | ATP2B4 | NA | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 1196 | 2.179 | 0.1208 | No |
| 6 | DUSP4 | NA | DUSP4 Entrez, Source | dual specificity phosphatase 4 | 1238 | 2.141 | 0.1412 | No |
| 7 | DCTN6 | NA | DCTN6 Entrez, Source | dynactin 6 | 1378 | 2.055 | 0.1571 | No |
| 8 | SNX10 | NA | SNX10 Entrez, Source | sorting nexin 10 | 1830 | 1.808 | 0.1591 | No |
| 9 | RAB1A | NA | RAB1A Entrez, Source | RAB1A, member RAS oncogene family | 1882 | 1.788 | 0.1755 | No |
| 10 | MBD5 | NA | MBD5 Entrez, Source | methyl-CpG binding domain protein 5 | 1950 | 1.753 | 0.1910 | No |
| 11 | PSMC3IP | NA | PSMC3IP Entrez, Source | PSMC3 interacting protein | 2007 | 1.720 | 0.2066 | No |
| 12 | FSTL1 | NA | FSTL1 Entrez, Source | follistatin-like 1 | 2211 | 1.629 | 0.2158 | No |
| 13 | TANK | NA | TANK Entrez, Source | TRAF family member-associated NFKB activator | 2236 | 1.621 | 0.2315 | No |
| 14 | PBX3 | NA | PBX3 Entrez, Source | pre-B-cell leukemia transcription factor 3 | 2238 | 1.620 | 0.2481 | No |
| 15 | C1QTNF1 | NA | C1QTNF1 Entrez, Source | C1q and tumor necrosis factor related protein 1 | 2296 | 1.597 | 0.2623 | No |
| 16 | MAN2A2 | NA | MAN2A2 Entrez, Source | mannosidase, alpha, class 2A, member 2 | 3349 | 1.199 | 0.2360 | No |
| 17 | ATP6V0E1 | NA | ATP6V0E1 Entrez, Source | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 3538 | 1.142 | 0.2408 | No |
| 18 | FUT6 | NA | FUT6 Entrez, Source | fucosyltransferase 6 (alpha (1,3) fucosyltransferase) | 4242 | 0.922 | 0.2244 | No |
| 19 | RAB7A | NA | 4769 | 0.796 | 0.2132 | No | ||
| 20 | ATMIN | NA | 4866 | 0.774 | 0.2176 | No | ||
| 21 | SLC31A1 | NA | SLC31A1 Entrez, Source | solute carrier family 31 (copper transporters), member 1 | 5332 | 0.654 | 0.2073 | No |
| 22 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 6433 | 0.461 | 0.1716 | No |
| 23 | SSR3 | NA | SSR3 Entrez, Source | signal sequence receptor, gamma (translocon-associated protein gamma) | 6571 | 0.444 | 0.1711 | No |
| 24 | STAMBP | NA | STAMBP Entrez, Source | STAM binding protein | 6839 | 0.414 | 0.1655 | No |
| 25 | COPS7A | NA | COPS7A Entrez, Source | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) | 6975 | 0.400 | 0.1647 | No |
| 26 | ACYP1 | NA | ACYP1 Entrez, Source | acylphosphatase 1, erythrocyte (common) type | 7068 | 0.390 | 0.1653 | No |
| 27 | C3orf14 | NA | C3ORF14 Entrez, Source | chromosome 3 open reading frame 14 | 7593 | 0.336 | 0.1495 | No |
| 28 | PDE6D | NA | PDE6D Entrez, Source | phosphodiesterase 6D, cGMP-specific, rod, delta | 7960 | 0.304 | 0.1392 | No |
| 29 | TAF11 | NA | TAF11 Entrez, Source | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 8181 | 0.286 | 0.1340 | No |
| 30 | APITD1 | NA | APITD1 Entrez, Source | apoptosis-inducing, TAF9-like domain 1 | 8265 | 0.280 | 0.1339 | No |
| 31 | GJA10 | NA | GJA10 Entrez, Source | gap junction protein, alpha 10, 59kDa | 8754 | 0.244 | 0.1184 | No |
| 32 | SMURF2 | NA | SMURF2 Entrez, Source | SMAD specific E3 ubiquitin protein ligase 2 | 8767 | 0.243 | 0.1205 | No |
| 33 | ITGAE | NA | ITGAE Entrez, Source | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 8946 | 0.233 | 0.1163 | No |
| 34 | RARB | NA | RARB Entrez, Source | retinoic acid receptor, beta | 9018 | 0.229 | 0.1161 | No |
| 35 | MAP4K3 | NA | MAP4K3 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 3 | 9380 | 0.209 | 0.1050 | No |
| 36 | FCHSD2 | NA | FCHSD2 Entrez, Source | FCH and double SH3 domains 2 | 9702 | 0.193 | 0.0951 | No |
| 37 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 9704 | 0.193 | 0.0971 | No |
| 38 | HIST1H3A | NA | HIST1H3A Entrez, Source | histone cluster 1, H3a | 10046 | 0.177 | 0.0864 | No |
| 39 | ENOX2 | NA | 10148 | 0.172 | 0.0844 | No | ||
| 40 | OPN1SW | NA | OPN1SW Entrez, Source | opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) | 10267 | 0.166 | 0.0818 | No |
| 41 | CFTR | NA | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 10537 | 0.154 | 0.0735 | No |
| 42 | MFAP5 | NA | MFAP5 Entrez, Source | microfibrillar associated protein 5 | 10872 | 0.138 | 0.0626 | No |
| 43 | KIAA1279 | NA | KIAA1279 Entrez, Source | KIAA1279 | 10965 | 0.135 | 0.0606 | No |
| 44 | S1PR1 | NA | 11982 | 0.091 | 0.0243 | No | ||
| 45 | ADIPOR2 | NA | ADIPOR2 Entrez, Source | adiponectin receptor 2 | 12241 | 0.081 | 0.0156 | No |
| 46 | YSK4 | NA | YSK4 Entrez, Source | yeast Sps1/Ste20-related kinase 4 (S. cerevisiae) | 13811 | 0.022 | -0.0417 | No |
| 47 | GH2 | NA | GH2 Entrez, Source | growth hormone 2 | 13989 | 0.015 | -0.0481 | No |
| 48 | IGF2BP2 | NA | IGF2BP2 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 2 | 14314 | 0.004 | -0.0599 | No |
| 49 | TRPC5 | NA | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 14503 | -0.003 | -0.0668 | No |
| 50 | MAGEC2 | NA | MAGEC2 Entrez, Source | melanoma antigen family C, 2 | 14511 | -0.003 | -0.0671 | No |
| 51 | FAM48A | NA | FAM48A Entrez, Source | family with sequence similarity 48, member A | 15338 | -0.034 | -0.0970 | No |
| 52 | LOXL2 | NA | LOXL2 Entrez, Source | lysyl oxidase-like 2 | 15463 | -0.039 | -0.1012 | No |
| 53 | AKAP10 | NA | AKAP10 Entrez, Source | A kinase (PRKA) anchor protein 10 | 17071 | -0.104 | -0.1591 | No |
| 54 | HSD11B1 | NA | HSD11B1 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 1 | 17896 | -0.147 | -0.1879 | No |
| 55 | CDC6 | NA | CDC6 Entrez, Source | CDC6 cell division cycle 6 homolog (S. cerevisiae) | 18525 | -0.187 | -0.2090 | No |
| 56 | CDR2 | NA | CDR2 Entrez, Source | cerebellar degeneration-related protein 2, 62kDa | 18628 | -0.196 | -0.2107 | No |
| 57 | STAG1 | NA | STAG1 Entrez, Source | stromal antigen 1 | 19360 | -0.256 | -0.2350 | No |
| 58 | MAPKAPK5 | NA | MAPKAPK5 Entrez, Source | mitogen-activated protein kinase-activated protein kinase 5 | 19895 | -0.309 | -0.2514 | No |
| 59 | TXNDC9 | NA | TXNDC9 Entrez, Source | thioredoxin domain containing 9 | 19985 | -0.319 | -0.2514 | No |
| 60 | VPS54 | NA | VPS54 Entrez, Source | vacuolar protein sorting 54 (S. cerevisiae) | 20186 | -0.340 | -0.2553 | No |
| 61 | PSME3 | NA | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 20663 | -0.400 | -0.2686 | No |
| 62 | NEK7 | NA | NEK7 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 7 | 20749 | -0.415 | -0.2675 | No |
| 63 | EIF5A2 | NA | EIF5A2 Entrez, Source | eukaryotic translation initiation factor 5A2 | 20936 | -0.443 | -0.2698 | No |
| 64 | SLC17A7 | NA | SLC17A7 Entrez, Source | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 | 21106 | -0.469 | -0.2712 | No |
| 65 | BET1 | NA | BET1 Entrez, Source | BET1 homolog (S. cerevisiae) | 21439 | -0.523 | -0.2781 | No |
| 66 | PDCD10 | NA | PDCD10 Entrez, Source | programmed cell death 10 | 21736 | -0.578 | -0.2830 | No |
| 67 | WDYHV1 | NA | 23115 | -0.861 | -0.3248 | Yes | ||
| 68 | RNF34 | NA | RNF34 Entrez, Source | ring finger protein 34 | 23117 | -0.861 | -0.3160 | Yes |
| 69 | SRPK1 | NA | SRPK1 Entrez, Source | SFRS protein kinase 1 | 23365 | -0.918 | -0.3157 | Yes |
| 70 | TMEM39A | NA | TMEM39A Entrez, Source | transmembrane protein 39A | 23480 | -0.947 | -0.3102 | Yes |
| 71 | C20orf20 | NA | C20ORF20 Entrez, Source | chromosome 20 open reading frame 20 | 23646 | -0.992 | -0.3061 | Yes |
| 72 | HSD17B12 | NA | HSD17B12 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 12 | 23989 | -1.086 | -0.3075 | Yes |
| 73 | PPME1 | NA | PPME1 Entrez, Source | protein phosphatase methylesterase 1 | 24341 | -1.193 | -0.3082 | Yes |
| 74 | NEDD4 | NA | NEDD4 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 4 | 24461 | -1.229 | -0.2999 | Yes |
| 75 | RIPK2 | NA | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 24745 | -1.325 | -0.2968 | Yes |
| 76 | PDHX | NA | PDHX Entrez, Source | pyruvate dehydrogenase complex, component X | 24858 | -1.364 | -0.2869 | Yes |
| 77 | SCML2 | NA | SCML2 Entrez, Source | sex comb on midleg-like 2 (Drosophila) | 25140 | -1.480 | -0.2821 | Yes |
| 78 | SLC43A3 | NA | SLC43A3 Entrez, Source | solute carrier family 43, member 3 | 25159 | -1.487 | -0.2675 | Yes |
| 79 | MRPL9 | NA | MRPL9 Entrez, Source | mitochondrial ribosomal protein L9 | 25261 | -1.526 | -0.2556 | Yes |
| 80 | ANKRD49 | NA | ANKRD49 Entrez, Source | ankyrin repeat domain 49 | 25373 | -1.581 | -0.2435 | Yes |
| 81 | IMPA1 | NA | IMPA1 Entrez, Source | inositol(myo)-1(or 4)-monophosphatase 1 | 25412 | -1.597 | -0.2285 | Yes |
| 82 | RIMS2 | NA | RIMS2 Entrez, Source | regulating synaptic membrane exocytosis 2 | 25441 | -1.612 | -0.2131 | Yes |
| 83 | C2CD2 | NA | 25445 | -1.616 | -0.1966 | Yes | ||
| 84 | MYO19 | NA | 25644 | -1.710 | -0.1864 | Yes | ||
| 85 | FAM111A | NA | FAM111A Entrez, Source | family with sequence similarity 111, member A | 25766 | -1.776 | -0.1727 | Yes |
| 86 | TRIP13 | NA | TRIP13 Entrez, Source | thyroid hormone receptor interactor 13 | 25884 | -1.849 | -0.1580 | Yes |
| 87 | PAPSS2 | NA | PAPSS2 Entrez, Source | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 25932 | -1.875 | -0.1405 | Yes |
| 88 | SHCBP1 | NA | SHCBP1 Entrez, Source | SHC SH2-domain binding protein 1 | 26401 | -2.215 | -0.1350 | Yes |
| 89 | SP140L | NA | 26576 | -2.362 | -0.1173 | Yes | ||
| 90 | TMEM156 | NA | TMEM156 Entrez, Source | transmembrane protein 156 | 26684 | -2.482 | -0.0958 | Yes |
| 91 | C4orf43 | NA | 26710 | -2.520 | -0.0709 | Yes | ||
| 92 | CSAG2 | NA | CSAG2 Entrez, Source | CSAG family, member 2 | 26795 | -2.637 | -0.0470 | Yes |
| 93 | UAP1 | NA | UAP1 Entrez, Source | UDP-N-acteylglucosamine pyrophosphorylase 1 | 26896 | -2.807 | -0.0219 | Yes |
| 94 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 27181 | -3.688 | 0.0054 | Yes |
